112 items (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SSRP1	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (603 aa)
	LOC100175005	HTH TFE/IIEalpha-type domain-containing protein. (343 aa)
	LOC100181739	Uncharacterized protein. (259 aa)
	Zf(c2h2)-114	General transcription factor IIH subunit. (395 aa)
	LOC100183995	Uncharacterized protein. (575 aa)
	F6X618_CIOIN	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (515 aa)
	LOC100179515	TFIIA-alpha and beta-like factor isoform X1. (332 aa)
	F6SJW4_CIOIN	Uncharacterized protein. (613 aa)
	F7A363_CIOIN	TBP-binding domain-containing protein. (480 aa)
	LOC100181502	TFIID_20kDa domain-containing protein. (187 aa)
	LOC100185111	BTP domain-containing protein. (231 aa)
	LOC100177214	Uncharacterized protein. (316 aa)
	F6UE50_CIOIN	BTP domain-containing protein. (671 aa)
	LOC100178698	Uncharacterized protein LOC100178698. (266 aa)
	LOC100183594	General transcription and DNA repair factor IIH helicase subunit XPB. (794 aa)
	LOC100180927	Uncharacterized protein LOC100180927. (266 aa)
	F6PPJ7_CIOIN	Uncharacterized protein. (205 aa)
	LOC100183139	Uncharacterized protein. (1035 aa)
	LOC100183393	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1141 aa)
	F6YSX7_CIOIN	RPOLD domain-containing protein. (345 aa)
	F6Y8T6_CIOIN	TAFII55_N domain-containing protein. (166 aa)
	cgrp-rcp	Calcitonin gene-related Peptide receptor component protein. (124 aa)
	LOC100187539	TFIIS N-terminal domain-containing protein. (658 aa)
	F6Z8X9_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
	F6YGZ1_CIOIN	Uncharacterized protein. (587 aa)
	LOC100186426	Negative elongation factor B. (605 aa)
	LOC100182348	elongin-A3 member D isoform X2. (622 aa)
	F7B658_CIOIN	TFIIB-type domain-containing protein. (658 aa)
	LOC100179613	Uncharacterized protein LOC100179613. (267 aa)
	F7BMK8_CIOIN	Uncharacterized protein. (243 aa)
	F6RMT1_CIOIN	Uncharacterized protein. (551 aa)
	F6QNK0_CIOIN	TAF domain-containing protein. (263 aa)
	LOC100177778	DNA-directed RNA polymerase II subunit RPB7. (172 aa)
	F6SKY6_CIOIN	HDAg domain-containing protein. (537 aa)
	LOC100177816	cyclin-H; Belongs to the cyclin family. (329 aa)
	F7AWN2_CIOIN	LisH domain-containing protein. (321 aa)
	F7AWC6_CIOIN	WD_REPEATS_REGION domain-containing protein. (272 aa)
	LOC100182171	Negative elongation factor E-like. (308 aa)
	LOC100178614	AF4/FMR2 family member 4 isoform X3. (1084 aa)
	F6VS86_CIOIN	AHD domain-containing protein. (660 aa)
	LOC100179943	General transcription factor IIF subunit 2. (257 aa)
	F6PY05_CIOIN	Uncharacterized protein. (246 aa)
	F6PX81_CIOIN	Plus3 domain-containing protein. (336 aa)
	F6QR00_CIOIN	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1183 aa)
	F6TZU9_CIOIN	Helicase ATP-binding domain-containing protein. (810 aa)
	F6SAD5_CIOIN	Uncharacterized protein; Belongs to the cyclin family. (514 aa)
	LOC100186818	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (520 aa)
	F6ZVH0_CIOIN	Uncharacterized protein. (205 aa)
	F6ZVG1_CIOIN	Uncharacterized protein; Belongs to the RNA polymerase beta chain family. (275 aa)
	F6S7U3_CIOIN	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (182 aa)
	F6S7T3_CIOIN	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (238 aa)
	F6SJH8_CIOIN	S1 motif domain-containing protein. (450 aa)
	F6SJ61_CIOIN	HTH_44 domain-containing protein. (505 aa)
	F6SIN5_CIOIN	RNA_pol_Rpb1_5 domain-containing protein. (749 aa)
	LOC100183293	Transcription elongation factor A protein 1. (298 aa)
	LOC100177272	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1814 aa)
	LOC100184400	DNA-directed RNA polymerase III subunit RPC4. (349 aa)
	zf(ring)-55	Zinc finger protein. (323 aa)
	LOC100181260	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (215 aa)
	LOC494392	Uncharacterized protein LOC494392. (131 aa)
	LOC100181821	Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (376 aa)
	F6PKT6_CIOIN	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (822 aa)
	LOC100175816	TPR_REGION domain-containing protein. (1034 aa)
	LOC100180649	Uncharacterized protein LOC100180649 isoform X1. (248 aa)
	F6U8F8_CIOIN	TAFH domain-containing protein. (598 aa)
	LOC100184759	Uncharacterized protein LOC100184759. (255 aa)
	LOC100182343	Transcription initiation factor IIB-like. (314 aa)
	F6Y5Q3_CIOIN	RPOLD domain-containing protein. (151 aa)
	LOC100178283	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (152 aa)
	F6XIG6_CIOIN	RPOL4c domain-containing protein. (133 aa)
	F6X941_CIOIN	Uncharacterized protein. (296 aa)
	F6Z277_CIOIN	Uncharacterized protein. (210 aa)
	F6UKG9_CIOIN	Uncharacterized protein. (255 aa)
	F7ATY3_CIOIN	Uncharacterized protein. (121 aa)
	LOC100182246	RNA polymerase I-specific transcription initiation factor RRN3. (588 aa)
	LOC104266855	DNA-directed RNA polymerase III subunit RPC8-like. (205 aa)
	LOC100177537	Protein kinase domain-containing protein. (1105 aa)
	F6V2C0_CIOIN	Uncharacterized protein. (228 aa)
	LOC100177176	Uncharacterized protein. (181 aa)
	F6XB76_CIOIN	SPT6_acidic domain-containing protein. (206 aa)
	LOC100182642	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa)
	F7BHW5_CIOIN	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (284 aa)
	F6T8R8_CIOIN	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (311 aa)
	F6YZE6_CIOIN	Uncharacterized protein. (166 aa)
	H2XJG6_CIOIN	Uncharacterized protein. (211 aa)
	spt4	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (122 aa)
	LOC113474223	Uncharacterized protein LOC113474223. (245 aa)
	LOC100178802	Transcription elongation factor SPT5. (1047 aa)
	LOC100181341	DNA-directed RNA polymerase II subunit RPB11-a isoform X1. (117 aa)
	H2XLT6_CIOIN	Uncharacterized protein. (264 aa)
	polr3k	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	H2XNY4_CIOIN	EAF domain-containing protein. (241 aa)
	H2XP40_CIOIN	RNA_pol_Rpb2_1 domain-containing protein. (178 aa)
	H2XPB0_CIOIN	RPOLA_N domain-containing protein. (207 aa)
	H2XQB7_CIOIN	PHD-type domain-containing protein. (164 aa)
	H2XR13_CIOIN	RNA_pol_Rpb2_6 domain-containing protein. (135 aa)
	LOC101242260	DNA-directed RNA polymerases I, II, and III subunit RPABC4. (79 aa)
	H2XTY0_CIOIN	Uncharacterized protein. (204 aa)
	H2XU12_CIOIN	Uncharacterized protein. (189 aa)
	H2XUU5_CIOIN	Uncharacterized protein. (532 aa)
	H2XVJ2_CIOIN	Uncharacterized protein. (141 aa)
	LOC100184165	General transcription factor IIH subunit 3-like. (309 aa)
	H2XW76_CIOIN	TAF domain-containing protein. (526 aa)
	LOC100186200	Uncharacterized protein LOC100186200. (248 aa)
	H2XZ54_CIOIN	RPOLD domain-containing protein. (286 aa)
	H2Y084_CIOIN	Uncharacterized protein. (262 aa)
	H2Y0B7_CIOIN	Uncharacterized protein. (498 aa)
	H2Y0J7_CIOIN	RPOLA_N domain-containing protein. (225 aa)
	H2Y0S6_CIOIN	Uncharacterized protein. (1003 aa)
	H2Y236_CIOIN	Uncharacterized protein. (237 aa)
	H2Y332_CIOIN	DUF3591 domain-containing protein. (202 aa)
	H2Y3S7_CIOIN	Uncharacterized protein. (633 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PKT6_CIOIN	F6PY05_CIOIN	ENSCINP00000018238	ENSCINP00000013040	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.480
F6PKT6_CIOIN	F6QR00_CIOIN	ENSCINP00000018238	ENSCINP00000013245	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.921
F6PKT6_CIOIN	F6SAD5_CIOIN	ENSCINP00000018238	ENSCINP00000014389	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein; Belongs to the cyclin family.	0.803
F6PKT6_CIOIN	F6SJ61_CIOIN	ENSCINP00000018238	ENSCINP00000015760	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	HTH_44 domain-containing protein.	0.563
F6PKT6_CIOIN	F6SJH8_CIOIN	ENSCINP00000018238	ENSCINP00000015757	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	S1 motif domain-containing protein.	0.563
F6PKT6_CIOIN	F6VS86_CIOIN	ENSCINP00000018238	ENSCINP00000012639	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	AHD domain-containing protein.	0.671
F6PKT6_CIOIN	F6X618_CIOIN	ENSCINP00000018238	ENSCINP00000003619	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.993
F6PKT6_CIOIN	F6XB76_CIOIN	ENSCINP00000018238	ENSCINP00000025852	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	SPT6_acidic domain-containing protein.	0.563
F6PKT6_CIOIN	F6XIG6_CIOIN	ENSCINP00000018238	ENSCINP00000021902	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOL4c domain-containing protein.	0.916
F6PKT6_CIOIN	F6Y5Q3_CIOIN	ENSCINP00000018238	ENSCINP00000019931	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOLD domain-containing protein.	0.859
F6PKT6_CIOIN	F6YSX7_CIOIN	ENSCINP00000018238	ENSCINP00000007337	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOLD domain-containing protein.	0.511
F6PKT6_CIOIN	F6Z8X9_CIOIN	ENSCINP00000018238	ENSCINP00000007900	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.729
F6PKT6_CIOIN	F7BMK8_CIOIN	ENSCINP00000018238	ENSCINP00000008989	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.480
F6PKT6_CIOIN	H2XJG6_CIOIN	ENSCINP00000018238	ENSCINP00000029798	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.818
F6PKT6_CIOIN	H2XLT6_CIOIN	ENSCINP00000018238	ENSCINP00000030618	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.480
F6PKT6_CIOIN	H2XNY4_CIOIN	ENSCINP00000018238	ENSCINP00000031367	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	EAF domain-containing protein.	0.848
F6PKT6_CIOIN	H2XVJ2_CIOIN	ENSCINP00000018238	ENSCINP00000033676	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.842
F6PKT6_CIOIN	H2XZ54_CIOIN	ENSCINP00000018238	ENSCINP00000034938	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	RPOLD domain-containing protein.	0.859
F6PKT6_CIOIN	H2Y084_CIOIN	ENSCINP00000018238	ENSCINP00000035318	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.480
F6PKT6_CIOIN	H2Y236_CIOIN	ENSCINP00000018238	ENSCINP00000035971	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Uncharacterized protein.	0.480