(10 nodes) Iron-sulfur cluster assembly network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	LOC100186125	Glutaredoxin-3. (330 aa)
	F6UAZ6_CIOIN	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family. (477 aa)
	LOC100177321	Uncharacterized protein. (220 aa)
	F7AUL7_CIOIN	Uncharacterized protein. (989 aa)
	LOC100179351	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. (601 aa)
	LOC100179970	Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (337 aa)
	LOC100177365	MIP18 family protein galla-2-like. (166 aa)
	H2XME2_CIOIN	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...] (298 aa)
	LOC100184069	Cytosolic iron-sulfur assembly component 2A isoform X1. (128 aa)
	H2XTT8_CIOIN	Uncharacterized protein; Belongs to the BolA/IbaG family. (89 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6UAZ6_CIOIN	F7AUL7_CIOIN	ENSCINP00000007104	ENSCINP00000009073	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Uncharacterized protein.	0.890
F6UAZ6_CIOIN	H2XME2_CIOIN	ENSCINP00000007104	ENSCINP00000030825	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]	0.685
F6UAZ6_CIOIN	H2XTT8_CIOIN	ENSCINP00000007104	ENSCINP00000033072	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Uncharacterized protein; Belongs to the BolA/IbaG family.	0.498
F6UAZ6_CIOIN	LOC100177321	ENSCINP00000007104	ENSCINP00000007293	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Uncharacterized protein.	0.584
F6UAZ6_CIOIN	LOC100177365	ENSCINP00000007104	ENSCINP00000017281	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	MIP18 family protein galla-2-like.	0.926
F6UAZ6_CIOIN	LOC100179351	ENSCINP00000007104	ENSCINP00000013654	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.	0.658
F6UAZ6_CIOIN	LOC100179970	ENSCINP00000007104	ENSCINP00000013921	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.929
F6UAZ6_CIOIN	LOC100184069	ENSCINP00000007104	ENSCINP00000031669	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	Cytosolic iron-sulfur assembly component 2A isoform X1.	0.761
F7AUL7_CIOIN	F6UAZ6_CIOIN	ENSCINP00000009073	ENSCINP00000007104	Uncharacterized protein.	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	0.890
F7AUL7_CIOIN	H2XME2_CIOIN	ENSCINP00000009073	ENSCINP00000030825	Uncharacterized protein.	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]	0.642
F7AUL7_CIOIN	H2XTT8_CIOIN	ENSCINP00000009073	ENSCINP00000033072	Uncharacterized protein.	Uncharacterized protein; Belongs to the BolA/IbaG family.	0.535
F7AUL7_CIOIN	LOC100177365	ENSCINP00000009073	ENSCINP00000017281	Uncharacterized protein.	MIP18 family protein galla-2-like.	0.989
F7AUL7_CIOIN	LOC100179351	ENSCINP00000009073	ENSCINP00000013654	Uncharacterized protein.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.	0.649
F7AUL7_CIOIN	LOC100179970	ENSCINP00000009073	ENSCINP00000013921	Uncharacterized protein.	Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.	0.986
F7AUL7_CIOIN	LOC100184069	ENSCINP00000009073	ENSCINP00000031669	Uncharacterized protein.	Cytosolic iron-sulfur assembly component 2A isoform X1.	0.928
F7AUL7_CIOIN	LOC100186125	ENSCINP00000009073	ENSCINP00000003944	Uncharacterized protein.	Glutaredoxin-3.	0.548
H2XME2_CIOIN	F6UAZ6_CIOIN	ENSCINP00000030825	ENSCINP00000007104	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]	Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.	0.685
H2XME2_CIOIN	F7AUL7_CIOIN	ENSCINP00000030825	ENSCINP00000009073	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]	Uncharacterized protein.	0.642
H2XME2_CIOIN	H2XTT8_CIOIN	ENSCINP00000030825	ENSCINP00000033072	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]	Uncharacterized protein; Belongs to the BolA/IbaG family.	0.883
H2XME2_CIOIN	LOC100177321	ENSCINP00000030825	ENSCINP00000007293	Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]	Uncharacterized protein.	0.522