(46 nodes) Nucleoside monophosphate metabolic process, and Purine catabolism network (Ciona intestinalis)

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	F6WDZ2_CIOIN	RIBORED_LARGE domain-containing protein. (193 aa)
	F7BL51_CIOIN	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (487 aa)
	F6UM48_CIOIN	Uncharacterized protein. (1861 aa)
	F6WSV9_CIOIN	A_deaminase domain-containing protein. (361 aa)
	LOC100181977	Uncharacterized protein. (232 aa)
	F6WZU2_CIOIN	dNK domain-containing protein. (265 aa)
	F6QJB5_CIOIN	HD domain-containing protein. (179 aa)
	LOC100186604	Uridine-cytidine kinase; Belongs to the uridine kinase family. (505 aa)
	LOC100181027	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (230 aa)
	F6SKP5_CIOIN	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (462 aa)
	LOC100178564	MGS domain-containing protein. (594 aa)
	LOC100186749	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (212 aa)
	ci-ak58	Radial spoke protein AK58; Belongs to the adenylate kinase family. (485 aa)
	LOC100175447	PfkB domain-containing protein. (356 aa)
	LOC100182043	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (228 aa)
	F6TAK8_CIOIN	Uncharacterized protein. (367 aa)
	F6YQS6_CIOIN	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (651 aa)
	F7BBQ5_CIOIN	Nucleoside diphosphate kinase. (163 aa)
	LOC100185509	Cytosolic 5'-nucleotidase 1A. (361 aa)
	LOC100176897	Uncharacterized protein. (688 aa)
	LOC100182436	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (346 aa)
	LOC100182227	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (206 aa)
	F6VKX1_CIOIN	Uridine-cytidine kinase; Belongs to the uridine kinase family. (243 aa)
	LOC100183021	Cytosolic purine 5'-nucleotidase isoform X4. (548 aa)
	F6Z6J2_CIOIN	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
	F6QF37_CIOIN	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (440 aa)
	LOC100177393	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
	F6WWW9_CIOIN	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (288 aa)
	LOC100178005	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (136 aa)
	F6XHJ8_CIOIN	NUC domain-containing protein. (475 aa)
	F7B963_CIOIN	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (136 aa)
	LOC113474072	Thymidylate kinase-like. (209 aa)
	F6USH9_CIOIN	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family. (384 aa)
	LOC100186893	UMP-CMP kinase 2, mitochondrial-like. (420 aa)
	ci-ndk/dm44	Radial spoke protein NDK/DM44; Belongs to the NDK family. (388 aa)
	LOC100180887	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
	F6ZC01_CIOIN	CMP/dCMP-type deaminase domain-containing protein. (191 aa)
	LOC100175348	U8 snoRNA-decapping enzyme-like isoform X2. (202 aa)
	F6YSG2_CIOIN	RWD domain-containing protein. (260 aa)
	LOC100183847	dUTPase domain-containing protein. (172 aa)
	LOC100184518	Uridine phosphorylase 2. (311 aa)
	H2XPZ0_CIOIN	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (155 aa)
	H2XT70_CIOIN	Thymidine kinase. (177 aa)
	LOC100186031	Adenine phosphoribosyltransferase-like. (185 aa)
	H2Y0K0_CIOIN	Nudix hydrolase domain-containing protein. (175 aa)
	H2Y207_CIOIN	A_deaminase domain-containing protein. (263 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QF37_CIOIN	F6SKP5_CIOIN	ENSCINP00000018101	ENSCINP00000008305	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein; Belongs to the 5'-nucleotidase family.	0.948
F6QF37_CIOIN	F6UM48_CIOIN	ENSCINP00000018101	ENSCINP00000003194	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.530
F6QF37_CIOIN	F6USH9_CIOIN	ENSCINP00000018101	ENSCINP00000023503	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family.	0.973
F6QF37_CIOIN	F6WDZ2_CIOIN	ENSCINP00000018101	ENSCINP00000000624	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	RIBORED_LARGE domain-containing protein.	0.413
F6QF37_CIOIN	F6WSV9_CIOIN	ENSCINP00000018101	ENSCINP00000004062	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	A_deaminase domain-containing protein.	0.544
F6QF37_CIOIN	F6WWW9_CIOIN	ENSCINP00000018101	ENSCINP00000019385	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.900
F6QF37_CIOIN	F6YQS6_CIOIN	ENSCINP00000018101	ENSCINP00000011173	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.942
F6QF37_CIOIN	F6Z6J2_CIOIN	ENSCINP00000018101	ENSCINP00000016539	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.537
F6QF37_CIOIN	F7BL51_CIOIN	ENSCINP00000018101	ENSCINP00000000763	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.999
F6QF37_CIOIN	H2XT70_CIOIN	ENSCINP00000018101	ENSCINP00000032854	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Thymidine kinase.	0.641
F6QF37_CIOIN	H2Y0K0_CIOIN	ENSCINP00000018101	ENSCINP00000035434	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Nudix hydrolase domain-containing protein.	0.900
F6QF37_CIOIN	H2Y207_CIOIN	ENSCINP00000018101	ENSCINP00000035942	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	A_deaminase domain-containing protein.	0.942
F6QF37_CIOIN	LOC100175348	ENSCINP00000018101	ENSCINP00000026711	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	U8 snoRNA-decapping enzyme-like isoform X2.	0.900
F6QF37_CIOIN	LOC100175447	ENSCINP00000018101	ENSCINP00000009198	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	PfkB domain-containing protein.	0.743
F6QF37_CIOIN	LOC100176897	ENSCINP00000018101	ENSCINP00000011812	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.753
F6QF37_CIOIN	LOC100178564	ENSCINP00000018101	ENSCINP00000008382	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	MGS domain-containing protein.	0.997
F6QF37_CIOIN	LOC100180887	ENSCINP00000018101	ENSCINP00000025829	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.970
F6QF37_CIOIN	LOC100181977	ENSCINP00000018101	ENSCINP00000005217	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.649
F6QF37_CIOIN	LOC100182436	ENSCINP00000018101	ENSCINP00000013612	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.977
F6QF37_CIOIN	LOC100183021	ENSCINP00000018101	ENSCINP00000015119	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Cytosolic purine 5'-nucleotidase isoform X4.	0.908