(25 nodes) Purine metabolism network (Ciona intestinalis)

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Predicted Interactions

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	F6WDZ2_CIOIN	RIBORED_LARGE domain-containing protein. (193 aa)
	F7BL51_CIOIN	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (487 aa)
	F6UM48_CIOIN	Uncharacterized protein. (1861 aa)
	F6QJB5_CIOIN	HD domain-containing protein. (179 aa)
	LOC100181027	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (230 aa)
	LOC100178564	MGS domain-containing protein. (594 aa)
	ci-ak58	Radial spoke protein AK58; Belongs to the adenylate kinase family. (485 aa)
	LOC100182043	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (228 aa)
	F6TAK8_CIOIN	Uncharacterized protein. (367 aa)
	F6YQS6_CIOIN	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (651 aa)
	F7BBQ5_CIOIN	Nucleoside diphosphate kinase. (163 aa)
	LOC100185509	Cytosolic 5'-nucleotidase 1A. (361 aa)
	LOC100176897	Uncharacterized protein. (688 aa)
	LOC100182436	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (346 aa)
	LOC100182227	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (206 aa)
	F6QF37_CIOIN	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (440 aa)
	LOC100177393	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
	F6XHJ8_CIOIN	NUC domain-containing protein. (475 aa)
	F6USH9_CIOIN	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family. (384 aa)
	ci-ndk/dm44	Radial spoke protein NDK/DM44; Belongs to the NDK family. (388 aa)
	LOC100180887	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
	LOC100175348	U8 snoRNA-decapping enzyme-like isoform X2. (202 aa)
	LOC100186031	Adenine phosphoribosyltransferase-like. (185 aa)
	H2Y0K0_CIOIN	Nudix hydrolase domain-containing protein. (175 aa)
	H2Y207_CIOIN	A_deaminase domain-containing protein. (263 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QF37_CIOIN	F6UM48_CIOIN	ENSCINP00000018101	ENSCINP00000003194	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.530
F6QF37_CIOIN	F6USH9_CIOIN	ENSCINP00000018101	ENSCINP00000023503	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family.	0.973
F6QF37_CIOIN	F6WDZ2_CIOIN	ENSCINP00000018101	ENSCINP00000000624	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	RIBORED_LARGE domain-containing protein.	0.413
F6QF37_CIOIN	F6YQS6_CIOIN	ENSCINP00000018101	ENSCINP00000011173	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.942
F6QF37_CIOIN	F7BL51_CIOIN	ENSCINP00000018101	ENSCINP00000000763	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.999
F6QF37_CIOIN	H2Y0K0_CIOIN	ENSCINP00000018101	ENSCINP00000035434	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Nudix hydrolase domain-containing protein.	0.900
F6QF37_CIOIN	H2Y207_CIOIN	ENSCINP00000018101	ENSCINP00000035942	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	A_deaminase domain-containing protein.	0.942
F6QF37_CIOIN	LOC100175348	ENSCINP00000018101	ENSCINP00000026711	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	U8 snoRNA-decapping enzyme-like isoform X2.	0.900
F6QF37_CIOIN	LOC100176897	ENSCINP00000018101	ENSCINP00000011812	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.753
F6QF37_CIOIN	LOC100178564	ENSCINP00000018101	ENSCINP00000008382	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	MGS domain-containing protein.	0.997
F6QF37_CIOIN	LOC100180887	ENSCINP00000018101	ENSCINP00000025829	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.970
F6QF37_CIOIN	LOC100182436	ENSCINP00000018101	ENSCINP00000013612	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.977
F6QF37_CIOIN	LOC100185509	ENSCINP00000018101	ENSCINP00000011780	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Cytosolic 5'-nucleotidase 1A.	0.918
F6QF37_CIOIN	LOC100186031	ENSCINP00000018101	ENSCINP00000035369	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenine phosphoribosyltransferase-like.	0.774
F6QJB5_CIOIN	F6TAK8_CIOIN	ENSCINP00000006425	ENSCINP00000010349	HD domain-containing protein.	Uncharacterized protein.	0.910
F6QJB5_CIOIN	F6UM48_CIOIN	ENSCINP00000006425	ENSCINP00000003194	HD domain-containing protein.	Uncharacterized protein.	0.945
F6QJB5_CIOIN	F6WDZ2_CIOIN	ENSCINP00000006425	ENSCINP00000000624	HD domain-containing protein.	RIBORED_LARGE domain-containing protein.	0.908
F6QJB5_CIOIN	F7BBQ5_CIOIN	ENSCINP00000006425	ENSCINP00000011619	HD domain-containing protein.	Nucleoside diphosphate kinase.	0.956
F6QJB5_CIOIN	F7BL51_CIOIN	ENSCINP00000006425	ENSCINP00000000763	HD domain-containing protein.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.487
F6QJB5_CIOIN	LOC100176897	ENSCINP00000006425	ENSCINP00000011812	HD domain-containing protein.	Uncharacterized protein.	0.546