(14 nodes) Mixed, incl. Adenylate kinase activity, and Ribonucleoside-diphosphate reductase activity network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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protein homology

Your Input:
	F6WDZ2_CIOIN	RIBORED_LARGE domain-containing protein. (193 aa)
	F6UM48_CIOIN	Uncharacterized protein. (1861 aa)
	F6QJB5_CIOIN	HD domain-containing protein. (179 aa)
	LOC100181027	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (230 aa)
	ci-ak58	Radial spoke protein AK58; Belongs to the adenylate kinase family. (485 aa)
	LOC100182043	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (228 aa)
	F6TAK8_CIOIN	Uncharacterized protein. (367 aa)
	F7BBQ5_CIOIN	Nucleoside diphosphate kinase. (163 aa)
	LOC100182227	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (206 aa)
	LOC100177393	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
	F6XHJ8_CIOIN	NUC domain-containing protein. (475 aa)
	ci-ndk/dm44	Radial spoke protein NDK/DM44; Belongs to the NDK family. (388 aa)
	LOC100180887	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
	LOC100186031	Adenine phosphoribosyltransferase-like. (185 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QJB5_CIOIN	F6TAK8_CIOIN	ENSCINP00000006425	ENSCINP00000010349	HD domain-containing protein.	Uncharacterized protein.	0.910
F6QJB5_CIOIN	F6UM48_CIOIN	ENSCINP00000006425	ENSCINP00000003194	HD domain-containing protein.	Uncharacterized protein.	0.945
F6QJB5_CIOIN	F6WDZ2_CIOIN	ENSCINP00000006425	ENSCINP00000000624	HD domain-containing protein.	RIBORED_LARGE domain-containing protein.	0.908
F6QJB5_CIOIN	F7BBQ5_CIOIN	ENSCINP00000006425	ENSCINP00000011619	HD domain-containing protein.	Nucleoside diphosphate kinase.	0.956
F6QJB5_CIOIN	LOC100181027	ENSCINP00000006425	ENSCINP00000007995	HD domain-containing protein.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.474
F6QJB5_CIOIN	LOC100182043	ENSCINP00000006425	ENSCINP00000009832	HD domain-containing protein.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.474
F6QJB5_CIOIN	LOC100182227	ENSCINP00000006425	ENSCINP00000014265	HD domain-containing protein.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.474
F6QJB5_CIOIN	LOC100186031	ENSCINP00000006425	ENSCINP00000035369	HD domain-containing protein.	Adenine phosphoribosyltransferase-like.	0.550
F6QJB5_CIOIN	ci-ak58	ENSCINP00000006425	ENSCINP00000008856	HD domain-containing protein.	Radial spoke protein AK58; Belongs to the adenylate kinase family.	0.474
F6QJB5_CIOIN	ci-ndk/dm44	ENSCINP00000006425	ENSCINP00000025129	HD domain-containing protein.	Radial spoke protein NDK/DM44; Belongs to the NDK family.	0.956
F6TAK8_CIOIN	F6QJB5_CIOIN	ENSCINP00000010349	ENSCINP00000006425	Uncharacterized protein.	HD domain-containing protein.	0.910
F6TAK8_CIOIN	F6UM48_CIOIN	ENSCINP00000010349	ENSCINP00000003194	Uncharacterized protein.	Uncharacterized protein.	0.977
F6TAK8_CIOIN	F6WDZ2_CIOIN	ENSCINP00000010349	ENSCINP00000000624	Uncharacterized protein.	RIBORED_LARGE domain-containing protein.	0.998
F6TAK8_CIOIN	F7BBQ5_CIOIN	ENSCINP00000010349	ENSCINP00000011619	Uncharacterized protein.	Nucleoside diphosphate kinase.	0.948
F6TAK8_CIOIN	LOC100177393	ENSCINP00000010349	ENSCINP00000018158	Uncharacterized protein.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. Belongs to the adenylate kinase family. AK6 subfamily.	0.900
F6TAK8_CIOIN	LOC100181027	ENSCINP00000010349	ENSCINP00000007995	Uncharacterized protein.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.	0.950
F6TAK8_CIOIN	LOC100182043	ENSCINP00000010349	ENSCINP00000009832	Uncharacterized protein.	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.944
F6TAK8_CIOIN	LOC100182227	ENSCINP00000010349	ENSCINP00000014265	Uncharacterized protein.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.943
F6TAK8_CIOIN	ci-ak58	ENSCINP00000010349	ENSCINP00000008856	Uncharacterized protein.	Radial spoke protein AK58; Belongs to the adenylate kinase family.	0.944
F6TAK8_CIOIN	ci-ndk/dm44	ENSCINP00000010349	ENSCINP00000025129	Uncharacterized protein.	Radial spoke protein NDK/DM44; Belongs to the NDK family.	0.948