(13 nodes) cGMP-mediated signaling, and Cyclic-nucleotide phosphodiesterase activity network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC100187498	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (624 aa)
	LOC100181727	Uncharacterized protein. (337 aa)
	F6TEA7_CIOIN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (587 aa)
	LOC100178591	Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (518 aa)
	F6Y8R5_CIOIN	GAF domain-containing protein. (216 aa)
	pdedelta	Phosphodiesterase delta-like protein; Belongs to the PDE6D/unc-119 family. (153 aa)
	F7BQ75_CIOIN	Phosphodiesterase. (784 aa)
	F7A9J1_CIOIN	Phosphodiesterase. (879 aa)
	F6QW33_CIOIN	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (316 aa)
	F6U053_CIOIN	PDEase_I_N domain-containing protein. (271 aa)
	F6YD09_CIOIN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (608 aa)
	H2XMC4_CIOIN	Uncharacterized protein. (78 aa)
	H2Y0S2_CIOIN	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (221 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QW33_CIOIN	F6TEA7_CIOIN	ENSCINP00000013533	ENSCINP00000004417	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.728
F6QW33_CIOIN	F6U053_CIOIN	ENSCINP00000013533	ENSCINP00000013648	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	PDEase_I_N domain-containing protein.	0.933
F6QW33_CIOIN	F6Y8R5_CIOIN	ENSCINP00000013533	ENSCINP00000007363	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	GAF domain-containing protein.	0.922
F6QW33_CIOIN	F7A9J1_CIOIN	ENSCINP00000013533	ENSCINP00000011667	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Phosphodiesterase.	0.919
F6QW33_CIOIN	F7BQ75_CIOIN	ENSCINP00000013533	ENSCINP00000010920	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Phosphodiesterase.	0.922
F6QW33_CIOIN	H2XMC4_CIOIN	ENSCINP00000013533	ENSCINP00000030807	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Uncharacterized protein.	0.900
F6QW33_CIOIN	H2Y0S2_CIOIN	ENSCINP00000013533	ENSCINP00000035506	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.908
F6QW33_CIOIN	LOC100178591	ENSCINP00000013533	ENSCINP00000004523	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.755
F6QW33_CIOIN	LOC100181727	ENSCINP00000013533	ENSCINP00000004212	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Uncharacterized protein.	0.917
F6QW33_CIOIN	LOC100187498	ENSCINP00000013533	ENSCINP00000003264	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.728
F6QW33_CIOIN	pdedelta	ENSCINP00000013533	ENSCINP00000008157	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Phosphodiesterase delta-like protein; Belongs to the PDE6D/unc-119 family.	0.918
F6TEA7_CIOIN	F6QW33_CIOIN	ENSCINP00000004417	ENSCINP00000013533	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.728
F6TEA7_CIOIN	F6U053_CIOIN	ENSCINP00000004417	ENSCINP00000013648	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase_I_N domain-containing protein.	0.672
F6TEA7_CIOIN	F6Y8R5_CIOIN	ENSCINP00000004417	ENSCINP00000007363	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	GAF domain-containing protein.	0.801
F6TEA7_CIOIN	F6YD09_CIOIN	ENSCINP00000004417	ENSCINP00000017414	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.586
F6TEA7_CIOIN	F7A9J1_CIOIN	ENSCINP00000004417	ENSCINP00000011667	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.728
F6TEA7_CIOIN	F7BQ75_CIOIN	ENSCINP00000004417	ENSCINP00000010920	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.738
F6TEA7_CIOIN	H2XMC4_CIOIN	ENSCINP00000004417	ENSCINP00000030807	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.650
F6TEA7_CIOIN	H2Y0S2_CIOIN	ENSCINP00000004417	ENSCINP00000035506	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.728
F6TEA7_CIOIN	LOC100178591	ENSCINP00000004417	ENSCINP00000004523	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.919