(21 nodes) Nicotinate and nicotinamide metabolism, and Isochorismatase-like network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	Sir2-d	Deacetylase sirtuin-type domain-containing protein. (91 aa)
	LOC100185313	Isochorismatase domain-containing protein 1-like. (270 aa)
	F6SSJ7_CIOIN	Isochorismatase domain-containing protein. (116 aa)
	F6YNT4_CIOIN	Coronin; Belongs to the WD repeat coronin family. (925 aa)
	LOC100181174	Uncharacterized protein. (403 aa)
	LOC100185251-2	Zinc finger protein. (339 aa)
	LOC100177271	Uncharacterized protein. (454 aa)
	F6Q548_CIOIN	Uncharacterized protein. (368 aa)
	LOC100183100	Uncharacterized protein LOC100183100. (202 aa)
	LOC100177202	Uncharacterized protein. (1029 aa)
	F7BJC2_CIOIN	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (703 aa)
	F7APS6_CIOIN	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (478 aa)
	LOC100185848	Deacetylase sirtuin-type domain-containing protein. (357 aa)
	F6TT30_CIOIN	CTP_transf_like domain-containing protein. (242 aa)
	F7A5R9_CIOIN	Uncharacterized protein. (342 aa)
	LOC778889	Deacetylase sirtuin-type domain-containing protein. (319 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	LOC100187016	Mitochondrial import inner membrane translocase subunit tim16-B. (132 aa)
	sir2-a	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (363 aa)
	H2XWF2_CIOIN	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (278 aa)
	H2Y3J4_CIOIN	Flavokinase domain-containing protein. (181 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q548_CIOIN	F6TT30_CIOIN	ENSCINP00000013305	ENSCINP00000024093	Uncharacterized protein.	CTP_transf_like domain-containing protein.	0.474
F6Q548_CIOIN	F7BJC2_CIOIN	ENSCINP00000013305	ENSCINP00000017941	Uncharacterized protein.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.474
F6Q548_CIOIN	LOC100181174	ENSCINP00000013305	ENSCINP00000010957	Uncharacterized protein.	Uncharacterized protein.	0.607
F6SLD6_CIOIN	F6TT30_CIOIN	ENSCINP00000027486	ENSCINP00000024093	Deacetylase sirtuin-type domain-containing protein.	CTP_transf_like domain-containing protein.	0.922
F6SLD6_CIOIN	F7BJC2_CIOIN	ENSCINP00000027486	ENSCINP00000017941	Deacetylase sirtuin-type domain-containing protein.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.944
F6SLD6_CIOIN	LOC100177202	ENSCINP00000027486	ENSCINP00000016569	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.900
F6SLD6_CIOIN	LOC100177271	ENSCINP00000027486	ENSCINP00000012890	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.912
F6SLD6_CIOIN	LOC100181174	ENSCINP00000027486	ENSCINP00000010957	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.926
F6SLD6_CIOIN	LOC100185251-2	ENSCINP00000027486	ENSCINP00000012226	Deacetylase sirtuin-type domain-containing protein.	Zinc finger protein.	0.541
F6SLD6_CIOIN	LOC100185848	ENSCINP00000027486	ENSCINP00000023359	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.724
F6SLD6_CIOIN	LOC778889	ENSCINP00000027486	ENSCINP00000027422	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.498
F6SLD6_CIOIN	Sir2-d	ENSCINP00000027486	ENSCINP00000002463	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.590
F6SLD6_CIOIN	sir2-a	ENSCINP00000027486	ENSCINP00000033928	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.605
F6SSJ7_CIOIN	F6TT30_CIOIN	ENSCINP00000004441	ENSCINP00000024093	Isochorismatase domain-containing protein.	CTP_transf_like domain-containing protein.	0.774
F6SSJ7_CIOIN	F7A5R9_CIOIN	ENSCINP00000004441	ENSCINP00000027289	Isochorismatase domain-containing protein.	Uncharacterized protein.	0.538
F6SSJ7_CIOIN	F7APS6_CIOIN	ENSCINP00000004441	ENSCINP00000022147	Isochorismatase domain-containing protein.	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	0.844
F6SSJ7_CIOIN	F7BJC2_CIOIN	ENSCINP00000004441	ENSCINP00000017941	Isochorismatase domain-containing protein.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.553
F6TT30_CIOIN	F6Q548_CIOIN	ENSCINP00000024093	ENSCINP00000013305	CTP_transf_like domain-containing protein.	Uncharacterized protein.	0.474
F6TT30_CIOIN	F6SLD6_CIOIN	ENSCINP00000024093	ENSCINP00000027486	CTP_transf_like domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.922
F6TT30_CIOIN	F6SSJ7_CIOIN	ENSCINP00000024093	ENSCINP00000004441	CTP_transf_like domain-containing protein.	Isochorismatase domain-containing protein.	0.774