(51 nodes) Glutathione metabolism network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100184425	Glutathione S-transferase 1-like. (199 aa)
	LOC100182061	Uncharacterized protein; Belongs to the GST superfamily. (202 aa)
	LOC100175706	Glutaredoxin domain-containing protein. (285 aa)
	F7AGK5_CIOIN	Uncharacterized protein. (144 aa)
	Gpx_c	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (139 aa)
	F7AE92_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (211 aa)
	LOC100179151	Glutathione S-transferase theta-1-like. (216 aa)
	F6X863_CIOIN	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (217 aa)
	F7A2U0_CIOIN	Uncharacterized protein. (156 aa)
	LOC100182976	Glutathione hydrolase 1 proenzyme isoform X2. (614 aa)
	LOC100184961	Glutathione S-transferase 1-1-like isoform X1; Belongs to the GST superfamily. (226 aa)
	F6WRW7_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (231 aa)
	F6XH38_CIOIN	Uncharacterized protein. (637 aa)
	F7AVB6_CIOIN	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (472 aa)
	F6V828_CIOIN	Uncharacterized protein. (476 aa)
	F7BDX5_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (204 aa)
	F6Y3D6_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
	LOC100183297	Glutathione S-transferase omega-1. (216 aa)
	F6X9G8_CIOIN	Aminopeptidase. (942 aa)
	F6V9K6_CIOIN	Uncharacterized protein. (224 aa)
	F7AV59_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (250 aa)
	LOC100176187	Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
	F6ZGZ0_CIOIN	Uncharacterized protein. (615 aa)
	F6ZGX7_CIOIN	Uncharacterized protein. (629 aa)
	F6SDP7_CIOIN	EGF-like domain-containing protein. (628 aa)
	F6VQ32_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (198 aa)
	F6ULB5_CIOIN	ERAP1_C domain-containing protein. (219 aa)
	LOC100176888	CYTOSOL_AP domain-containing protein. (524 aa)
	F6S5A6_CIOIN	CYTOSOL_AP domain-containing protein. (515 aa)
	LOC100178265	Glutathione S-transferase 1; Belongs to the GST superfamily. (224 aa)
	F6XP62_CIOIN	Uncharacterized protein. (261 aa)
	LOC100179669	Glutathione S-transferase omega-1-like; Belongs to the GST superfamily. (245 aa)
	LOC100187183	Uncharacterized protein. (152 aa)
	F6WBE9_CIOIN	GSH_synthase domain-containing protein. (207 aa)
	LOC100180646	Glutathione synthetase. (448 aa)
	LOC100176159	Uncharacterized protein. (1214 aa)
	LOC100177610	Peroxiredoxin-6-like isoform X1. (222 aa)
	F6RAJ1_CIOIN	Uncharacterized protein; Belongs to the GST superfamily. (254 aa)
	F6QDM2_CIOIN	GST C-terminal domain-containing protein. (139 aa)
	LOC100178653	Glutathione S-transferase Mu 1-like. (225 aa)
	gpx7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
	F6UB97_CIOIN	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (213 aa)
	LOC100177239	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (197 aa)
	F6PWH2_CIOIN	Uncharacterized protein. (201 aa)
	F6SBJ2_CIOIN	Aldo_ket_red domain-containing protein. (299 aa)
	LOC100186966	Uncharacterized protein. (202 aa)
	LOC100186348	Glutathione S-transferase kappa. (225 aa)
	H2XPV5_CIOIN	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (184 aa)
	H2XQS5_CIOIN	Thioredoxin domain-containing protein. (223 aa)
	H2XYF3_CIOIN	Aminopeptidase. (915 aa)
	LOC100186137	CYTOSOL_AP domain-containing protein. (512 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PWH2_CIOIN	F6SDP7_CIOIN	ENSCINP00000025320	ENSCINP00000012732	Uncharacterized protein.	EGF-like domain-containing protein.	0.909
F6PWH2_CIOIN	F6VQ32_CIOIN	ENSCINP00000025320	ENSCINP00000012909	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.902
F6PWH2_CIOIN	F7BDX5_CIOIN	ENSCINP00000025320	ENSCINP00000009038	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.902
F6PWH2_CIOIN	LOC100175706	ENSCINP00000025320	ENSCINP00000001257	Uncharacterized protein.	Glutaredoxin domain-containing protein.	0.900
F6PWH2_CIOIN	LOC100177239	ENSCINP00000025320	ENSCINP00000025179	Uncharacterized protein.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.902
F6PWH2_CIOIN	LOC100182061	ENSCINP00000025320	ENSCINP00000001243	Uncharacterized protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.902
F6PWH2_CIOIN	LOC100184425	ENSCINP00000025320	ENSCINP00000000153	Uncharacterized protein.	Glutathione S-transferase 1-like.	0.902
F6PWH2_CIOIN	LOC100186966	ENSCINP00000025320	ENSCINP00000027377	Uncharacterized protein.	Uncharacterized protein.	0.902
F6QDM2_CIOIN	F6RAJ1_CIOIN	ENSCINP00000020777	ENSCINP00000020024	GST C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.710
F6QDM2_CIOIN	F6UB97_CIOIN	ENSCINP00000020777	ENSCINP00000024985	GST C-terminal domain-containing protein.	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.650
F6QDM2_CIOIN	F6V828_CIOIN	ENSCINP00000020777	ENSCINP00000008537	GST C-terminal domain-containing protein.	Uncharacterized protein.	0.697
F6QDM2_CIOIN	F6V9K6_CIOIN	ENSCINP00000020777	ENSCINP00000010811	GST C-terminal domain-containing protein.	Uncharacterized protein.	0.710
F6QDM2_CIOIN	F6VQ32_CIOIN	ENSCINP00000020777	ENSCINP00000012909	GST C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.731
F6QDM2_CIOIN	F6WBE9_CIOIN	ENSCINP00000020777	ENSCINP00000019096	GST C-terminal domain-containing protein.	GSH_synthase domain-containing protein.	0.690
F6QDM2_CIOIN	F6WRW7_CIOIN	ENSCINP00000020777	ENSCINP00000004318	GST C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.710
F6QDM2_CIOIN	F6X863_CIOIN	ENSCINP00000020777	ENSCINP00000003399	GST C-terminal domain-containing protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.708
F6QDM2_CIOIN	F6XP62_CIOIN	ENSCINP00000020777	ENSCINP00000017453	GST C-terminal domain-containing protein.	Uncharacterized protein.	0.688
F6QDM2_CIOIN	F6Y3D6_CIOIN	ENSCINP00000020777	ENSCINP00000009156	GST C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.652
F6QDM2_CIOIN	F7A2U0_CIOIN	ENSCINP00000020777	ENSCINP00000003836	GST C-terminal domain-containing protein.	Uncharacterized protein.	0.697
F6QDM2_CIOIN	F7AE92_CIOIN	ENSCINP00000020777	ENSCINP00000002443	GST C-terminal domain-containing protein.	Uncharacterized protein; Belongs to the GST superfamily.	0.710