(48 nodes) Sphingolipid metabolism, and Ceramide biosynthetic process network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100178882	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (167 aa)
	LOC100169897	Homeobox transcription factor, LAG1-like 4. (346 aa)
	F6PH94_CIOIN	Uncharacterized protein. (268 aa)
	F6SYF4_CIOIN	Uncharacterized protein. (572 aa)
	LOC100186491	Ceramide synthase 1-like. (338 aa)
	F6TI55_CIOIN	Uncharacterized protein. (753 aa)
	LOC100184115	Ceramide synthase 1. (335 aa)
	F6YIB7_CIOIN	DAGKc domain-containing protein. (608 aa)
	F6Q8G4_CIOIN	Uncharacterized protein; Belongs to the acid ceramidase family. (392 aa)
	F6ZYB8_CIOIN	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	LOC100183243	DHHA2 domain-containing protein. (378 aa)
	F6RCR0_CIOIN	Neutral ceramidase. (771 aa)
	LOC100186563	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	F6QEE6_CIOIN	Neutral ceramidase. (748 aa)
	LOC100178248	3-ketodihydrosphingosine reductase-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (331 aa)
	F6WV27_CIOIN	acidPPc domain-containing protein. (405 aa)
	F6XUD5_CIOIN	Aminotran_1_2 domain-containing protein. (477 aa)
	F6V9F0_CIOIN	Aminotran_1_2 domain-containing protein. (343 aa)
	F6UTT2_CIOIN	Neutral ceramidase. (688 aa)
	F7BDM8_CIOIN	Uncharacterized protein. (285 aa)
	lag1-like1	Transcription factor protein. (382 aa)
	F6Q539_CIOIN	DAGKc domain-containing protein. (383 aa)
	F6S925_CIOIN	TLC domain-containing protein. (354 aa)
	Lass6	Uncharacterized protein. (349 aa)
	F7AA01_CIOIN	Glucosylceramidase. (561 aa)
	F7A1T4_CIOIN	Uncharacterized protein. (401 aa)
	F6Q9D5_CIOIN	Metallophos domain-containing protein. (435 aa)
	LOC100178137	Uncharacterized protein LOC100178137. (444 aa)
	F6Y921_CIOIN	Glyco_hydro_59M domain-containing protein. (677 aa)
	LOC100178733	Sphingolipid delta(4)-desaturase DES1-like; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (322 aa)
	F6TJR3_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (242 aa)
	F6VAL7_CIOIN	Uncharacterized protein. (235 aa)
	F7AN60_CIOIN	Uncharacterized protein. (424 aa)
	F6UTV8_CIOIN	PALP domain-containing protein. (332 aa)
	F7AV79_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (228 aa)
	F7ARL3_CIOIN	SAM domain-containing protein. (425 aa)
	LOC100178245	Uncharacterized protein. (243 aa)
	F6WVN4_CIOIN	acidPPc domain-containing protein. (302 aa)
	H2XJY8_CIOIN	Glucosylceramidase. (518 aa)
	H2XM50_CIOIN	Lipid_DES domain-containing protein; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. (323 aa)
	H2XMX0_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (143 aa)
	LOC100177090	Ceramide synthase 1-like. (344 aa)
	H2XNN8_CIOIN	PALP domain-containing protein. (316 aa)
	H2XP03_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (110 aa)
	H2XQD5_CIOIN	Aminotran_1_2 domain-containing protein. (499 aa)
	LOC100182515	Sphingomyelin synthase-related 1-like. (274 aa)
	H2XUX1_CIOIN	Uncharacterized protein. (78 aa)
	H2XVK2_CIOIN	Aminotran_1_2 domain-containing protein. (535 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PH94_CIOIN	F6Q8G4_CIOIN	ENSCINP00000001408	ENSCINP00000004990	Uncharacterized protein.	Uncharacterized protein; Belongs to the acid ceramidase family.	0.664
F6PH94_CIOIN	F6TI55_CIOIN	ENSCINP00000001408	ENSCINP00000002919	Uncharacterized protein.	Uncharacterized protein.	0.908
F6PH94_CIOIN	F6TJR3_CIOIN	ENSCINP00000001408	ENSCINP00000021779	Uncharacterized protein.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.652
F6PH94_CIOIN	F6UTT2_CIOIN	ENSCINP00000001408	ENSCINP00000011274	Uncharacterized protein.	Neutral ceramidase.	0.665
F6PH94_CIOIN	F6VAL7_CIOIN	ENSCINP00000001408	ENSCINP00000022564	Uncharacterized protein.	Uncharacterized protein.	0.903
F6PH94_CIOIN	F6WV27_CIOIN	ENSCINP00000001408	ENSCINP00000007659	Uncharacterized protein.	acidPPc domain-containing protein.	0.901
F6PH94_CIOIN	F6WVN4_CIOIN	ENSCINP00000001408	ENSCINP00000026500	Uncharacterized protein.	acidPPc domain-containing protein.	0.901
F6PH94_CIOIN	F6Y921_CIOIN	ENSCINP00000001408	ENSCINP00000019330	Uncharacterized protein.	Glyco_hydro_59M domain-containing protein.	0.900
F6PH94_CIOIN	F6ZYB8_CIOIN	ENSCINP00000001408	ENSCINP00000005699	Uncharacterized protein.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	0.906
F6PH94_CIOIN	F7A1T4_CIOIN	ENSCINP00000001408	ENSCINP00000017071	Uncharacterized protein.	Uncharacterized protein.	0.901
F6PH94_CIOIN	F7AA01_CIOIN	ENSCINP00000001408	ENSCINP00000016220	Uncharacterized protein.	Glucosylceramidase.	0.900
F6PH94_CIOIN	F7AN60_CIOIN	ENSCINP00000001408	ENSCINP00000022682	Uncharacterized protein.	Uncharacterized protein.	0.902
F6PH94_CIOIN	F7AV79_CIOIN	ENSCINP00000001408	ENSCINP00000023348	Uncharacterized protein.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.652
F6PH94_CIOIN	H2XJY8_CIOIN	ENSCINP00000001408	ENSCINP00000029970	Uncharacterized protein.	Glucosylceramidase.	0.900
F6PH94_CIOIN	H2XM50_CIOIN	ENSCINP00000001408	ENSCINP00000030732	Uncharacterized protein.	Lipid_DES domain-containing protein; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.	0.902
F6PH94_CIOIN	H2XMX0_CIOIN	ENSCINP00000001408	ENSCINP00000031003	Uncharacterized protein.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.650
F6PH94_CIOIN	LOC100177090	ENSCINP00000001408	ENSCINP00000031017	Uncharacterized protein.	Ceramide synthase 1-like.	0.900
F6PH94_CIOIN	LOC100178733	ENSCINP00000001408	ENSCINP00000020056	Uncharacterized protein.	Sphingolipid delta(4)-desaturase DES1-like; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.	0.902
F6PH94_CIOIN	LOC100178882	ENSCINP00000001408	ENSCINP00000000095	Uncharacterized protein.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.652
F6PH94_CIOIN	LOC100184115	ENSCINP00000001408	ENSCINP00000002922	Uncharacterized protein.	Ceramide synthase 1.	0.900