(72 nodes) Mixed, incl. Small GTPase Rho, and RAC1 GTPase cycle network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Iqgap	Ras-GAP domain-containing protein. (549 aa)
	cdc42	Uncharacterized protein. (95 aa)
	LOC448957	Rac4 protein. (193 aa)
	Rac3a	Uncharacterized protein. (194 aa)
	LOC448958	Rac5 protein. (193 aa)
	LOC445702	Rac1 protein isoform X1. (192 aa)
	ci-arfgap-3	Zinc finger protein Ci-ArfGAP-3. (760 aa)
	F7BJE1_CIOIN	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (213 aa)
	F7BIX8_CIOIN	Uncharacterized protein; Belongs to the DOCK family. (2044 aa)
	rhoc	RhoA protein. (193 aa)
	F6R6F3_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1324 aa)
	F6QE00_CIOIN	FH2 domain-containing protein. (172 aa)
	F6ZNL7_CIOIN	FH2 domain-containing protein. (158 aa)
	F6WYA7_CIOIN	SH3 domain-containing protein. (166 aa)
	F6UY31_CIOIN	Uncharacterized protein. (487 aa)
	F7AXL0_CIOIN	Uncharacterized protein. (1039 aa)
	F6RST4_CIOIN	F-BAR domain-containing protein. (286 aa)
	rcl2	Rac and Cdc42-like 2 protein isoform X1. (192 aa)
	F6U465_CIOIN	Uncharacterized protein. (743 aa)
	LOC100180999	Uncharacterized protein. (716 aa)
	F6ZCE0_CIOIN	Non-specific serine/threonine protein kinase. (619 aa)
	F6UKS5_CIOIN	Uncharacterized protein; Belongs to the DOCK family. (1360 aa)
	F7B7Y1_CIOIN	Uncharacterized protein; Belongs to the DOCK family. (1597 aa)
	F7B7X5_CIOIN	Uncharacterized protein. (420 aa)
	F6PJW3_CIOIN	Uncharacterized protein. (162 aa)
	F6QZH0_CIOIN	Protein kinase domain-containing protein. (459 aa)
	F6XQ16_CIOIN	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (657 aa)
	ENSCINP00000017996	Uncharacterized protein. (312 aa)
	LOC445704	TC10 protein. (193 aa)
	LOC100175164	Uncharacterized protein. (943 aa)
	F6WV80_CIOIN	Protein kinase domain-containing protein. (1197 aa)
	F6WUP8_CIOIN	DHR-2 domain-containing protein; Belongs to the DOCK family. (408 aa)
	LOC100177780	Nuclear receptor 2C2-associated protein-like. (143 aa)
	LOC100186680	Caspase recruitment domain-containing protein 11-like isoform X1. (418 aa)
	F6ZUV3_CIOIN	S5A_REDUCTASE domain-containing protein. (262 aa)
	F6V921_CIOIN	Uncharacterized protein. (277 aa)
	rhob	Rif protein. (249 aa)
	Rac2	Uncharacterized protein. (192 aa)
	F6SH91_CIOIN	Uncharacterized protein. (206 aa)
	F7BLG0_CIOIN	Uncharacterized protein. (527 aa)
	F6V341_CIOIN	Uncharacterized protein. (331 aa)
	F6PQW3_CIOIN	Uncharacterized protein. (937 aa)
	rcl1	Rac and Cdc42-like 1 protein. (194 aa)
	F6YAG6_CIOIN	Uncharacterized protein. (403 aa)
	F6VW94_CIOIN	PH domain-containing protein. (128 aa)
	F6XSQ9_CIOIN	SH2 domain-containing protein. (352 aa)
	F6X4P6_CIOIN	Uncharacterized protein. (262 aa)
	H2XKE4_CIOIN	Uncharacterized protein. (103 aa)
	H2XLB3_CIOIN	Uncharacterized protein. (236 aa)
	H2XLY5_CIOIN	DMPK_coil domain-containing protein. (189 aa)
	H2XMB5_CIOIN	Uncharacterized protein. (116 aa)
	H2XMN3_CIOIN	Uncharacterized protein. (136 aa)
	H2XMV0_CIOIN	Phorbol-ester/DAG-type domain-containing protein. (31 aa)
	H2XP78_CIOIN	RRM domain-containing protein. (85 aa)
	H2XPF3_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (226 aa)
	H2XPI6_CIOIN	DH domain-containing protein. (166 aa)
	H2XQ68_CIOIN	Drf_GBD domain-containing protein. (190 aa)
	H2XQJ0_CIOIN	DUF3398 domain-containing protein. (490 aa)
	H2XVF8_CIOIN	Non-specific serine/threonine protein kinase. (699 aa)
	H2XVI5_CIOIN	AGC-kinase C-terminal domain-containing protein. (240 aa)
	H2XVP3_CIOIN	FH2 domain-containing protein. (145 aa)
	H2XVQ2_CIOIN	Uncharacterized protein. (1694 aa)
	LOC100179548	Clarin-3-like. (235 aa)
	H2XXC7_CIOIN	Phorbol-ester/DAG-type domain-containing protein. (223 aa)
	H2XY43_CIOIN	Uncharacterized protein. (388 aa)
	H2XZ82_CIOIN	Uncharacterized protein. (103 aa)
	H2XZX4_CIOIN	FH2 domain-containing protein. (220 aa)
	H2XZX6_CIOIN	Phorbol-ester/DAG-type domain-containing protein. (399 aa)
	H2Y088_CIOIN	Calponin-homology (CH) domain-containing protein. (343 aa)
	Rhou	Uncharacterized protein. (259 aa)
	H2Y3I9_CIOIN	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (222 aa)
	LOC100185957	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1. (624 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCINP00000017996	H2XXC7_CIOIN	ENSCINP00000017996	ENSCINP00000034311	Uncharacterized protein.	Phorbol-ester/DAG-type domain-containing protein.	0.418
ENSCINP00000017996	LOC100186680	ENSCINP00000017996	ENSCINP00000020343	Uncharacterized protein.	Caspase recruitment domain-containing protein 11-like isoform X1.	0.544
F6PJW3_CIOIN	F6QZH0_CIOIN	ENSCINP00000016748	ENSCINP00000016849	Uncharacterized protein.	Protein kinase domain-containing protein.	0.627
F6PJW3_CIOIN	F7B7X5_CIOIN	ENSCINP00000016748	ENSCINP00000015251	Uncharacterized protein.	Uncharacterized protein.	0.453
F6PJW3_CIOIN	H2XLB3_CIOIN	ENSCINP00000016748	ENSCINP00000030445	Uncharacterized protein.	Uncharacterized protein.	0.900
F6PJW3_CIOIN	H2XMB5_CIOIN	ENSCINP00000016748	ENSCINP00000030798	Uncharacterized protein.	Uncharacterized protein.	0.433
F6PJW3_CIOIN	H2XXC7_CIOIN	ENSCINP00000016748	ENSCINP00000034311	Uncharacterized protein.	Phorbol-ester/DAG-type domain-containing protein.	0.654
F6PJW3_CIOIN	LOC100186680	ENSCINP00000016748	ENSCINP00000020343	Uncharacterized protein.	Caspase recruitment domain-containing protein 11-like isoform X1.	0.564
F6PJW3_CIOIN	LOC445702	ENSCINP00000016748	ENSCINP00000004782	Uncharacterized protein.	Rac1 protein isoform X1.	0.434
F6PJW3_CIOIN	LOC445704	ENSCINP00000016748	ENSCINP00000018289	Uncharacterized protein.	TC10 protein.	0.433
F6PJW3_CIOIN	LOC448957	ENSCINP00000016748	ENSCINP00000004748	Uncharacterized protein.	Rac4 protein.	0.434
F6PJW3_CIOIN	LOC448958	ENSCINP00000016748	ENSCINP00000004771	Uncharacterized protein.	Rac5 protein.	0.434
F6PJW3_CIOIN	Rac2	ENSCINP00000016748	ENSCINP00000024029	Uncharacterized protein.	Uncharacterized protein.	0.434
F6PJW3_CIOIN	Rac3a	ENSCINP00000016748	ENSCINP00000004757	Uncharacterized protein.	Uncharacterized protein.	0.434
F6PJW3_CIOIN	Rhou	ENSCINP00000016748	ENSCINP00000035599	Uncharacterized protein.	Uncharacterized protein.	0.434
F6PJW3_CIOIN	cdc42	ENSCINP00000016748	ENSCINP00000001500	Uncharacterized protein.	Uncharacterized protein.	0.434
F6PJW3_CIOIN	rcl1	ENSCINP00000016748	ENSCINP00000025708	Uncharacterized protein.	Rac and Cdc42-like 1 protein.	0.434
F6PJW3_CIOIN	rcl2	ENSCINP00000016748	ENSCINP00000011550	Uncharacterized protein.	Rac and Cdc42-like 2 protein isoform X1.	0.434
F6PJW3_CIOIN	rhob	ENSCINP00000016748	ENSCINP00000023349	Uncharacterized protein.	Rif protein.	0.697
F6PJW3_CIOIN	rhoc	ENSCINP00000016748	ENSCINP00000006386	Uncharacterized protein.	RhoA protein.	0.699