(53 nodes) Telomere maintenance network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2XN24_CIOIN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (158 aa)
	LOC100176337	EKC/KEOPS complex subunit TPRKB; Belongs to the CGI121/TPRKB family. (171 aa)
	H2XNU2_CIOIN	Uncharacterized protein. (214 aa)
	H2XQK9_CIOIN	Uncharacterized protein. (836 aa)
	LOC100187276	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (904 aa)
	F7ABN7_CIOIN	F-box domain-containing protein. (241 aa)
	F7A9P4_CIOIN	NUC194 domain-containing protein. (726 aa)
	F6YY15_CIOIN	ERCC4 domain-containing protein. (826 aa)
	F6VBZ6_CIOIN	Telo_bind domain-containing protein. (527 aa)
	nfrkb	Uncharacterized protein. (310 aa)
	H2XJN2_CIOIN	RECA_2 domain-containing protein. (255 aa)
	F6WGY1_CIOIN	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (246 aa)
	LOC100177452	Uncharacterized protein. (603 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	LOC100175935	Ubiquitin carboxyl-terminal hydrolase. (328 aa)
	F7AE79_CIOIN	SP-RING-type domain-containing protein. (239 aa)
	F6RZ99_CIOIN	Zinc-hook domain-containing protein. (477 aa)
	F6RYY5_CIOIN	AAA_23 domain-containing protein. (400 aa)
	LOC100179894	Werner syndrome ATP-dependent helicase homolog isoform X1. (1194 aa)
	F6QHZ5_CIOIN	FHA domain-containing protein. (234 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (607 aa)
	LOC100185732	DRMBL domain-containing protein. (277 aa)
	F6TV58_CIOIN	Uncharacterized protein. (147 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	F6U2M6_CIOIN	PUA domain-containing protein. (528 aa)
	LOC100177411	RuvB-like helicase; Belongs to the RuvB family. (467 aa)
	F6R982_CIOIN	WD_REPEATS_REGION domain-containing protein. (433 aa)
	LOC100185652	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (530 aa)
	F6Q9T0_CIOIN	Uncharacterized protein. (231 aa)
	F6SK60_CIOIN	Uncharacterized protein. (372 aa)
	LOC100179869	Checkpoint protein; Belongs to the HUS1 family. (286 aa)
	LOC100181113	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (198 aa)
	F6VVB7_CIOIN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (315 aa)
	LOC100184120	CS domain-containing protein. (193 aa)
	zf(c2h2)-11	Uncharacterized protein. (504 aa)
	F6W282_CIOIN	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (313 aa)
	LOC100181789	AAA_23 domain-containing protein. (1070 aa)
	LOC100186474	Uncharacterized protein LOC100186474 isoform X1. (164 aa)
	H2XL64_CIOIN	SMC_N domain-containing protein. (1036 aa)
	H2XLD1_CIOIN	Telomere_reg-2 domain-containing protein. (689 aa)
	H2Y3R0_CIOIN	Uncharacterized protein. (173 aa)
	LOC100183893	Uncharacterized protein. (480 aa)
	H2Y3M4_CIOIN	Uncharacterized protein. (185 aa)
	H2Y3C6_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (540 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	LOC100182514	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	LOC100184449	PIN2/TERF1-interacting telomerase inhibitor 1-like. (260 aa)
	H2XV49_CIOIN	FAT domain-containing protein. (219 aa)
	H2XUG9_CIOIN	Helicase ATP-binding domain-containing protein. (310 aa)
	LOC100181925	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa)
	H2XS48_CIOIN	TROVE domain-containing protein. (331 aa)
	H2XRC3_CIOIN	Uncharacterized protein. (224 aa)
	H2XR99_CIOIN	FHA domain-containing protein. (427 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q9T0_CIOIN	F6QHZ5_CIOIN	ENSCINP00000018150	ENSCINP00000004918	Uncharacterized protein.	FHA domain-containing protein.	0.696
F6Q9T0_CIOIN	F6RJ65_CIOIN	ENSCINP00000018150	ENSCINP00000001490	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.835
F6Q9T0_CIOIN	F6RYY5_CIOIN	ENSCINP00000018150	ENSCINP00000003245	Uncharacterized protein.	AAA_23 domain-containing protein.	0.704
F6Q9T0_CIOIN	F6RZ99_CIOIN	ENSCINP00000018150	ENSCINP00000003235	Uncharacterized protein.	Zinc-hook domain-containing protein.	0.704
F6Q9T0_CIOIN	F6SK60_CIOIN	ENSCINP00000018150	ENSCINP00000010637	Uncharacterized protein.	Uncharacterized protein.	0.544
F6Q9T0_CIOIN	F6TV58_CIOIN	ENSCINP00000018150	ENSCINP00000008579	Uncharacterized protein.	Uncharacterized protein.	0.756
F6Q9T0_CIOIN	F6VBZ6_CIOIN	ENSCINP00000018150	ENSCINP00000027127	Uncharacterized protein.	Telo_bind domain-containing protein.	0.572
F6Q9T0_CIOIN	F6W282_CIOIN	ENSCINP00000018150	ENSCINP00000016620	Uncharacterized protein.	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.456
F6Q9T0_CIOIN	F6WGY1_CIOIN	ENSCINP00000018150	ENSCINP00000000037	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.932
F6Q9T0_CIOIN	F6YY15_CIOIN	ENSCINP00000018150	ENSCINP00000024251	Uncharacterized protein.	ERCC4 domain-containing protein.	0.832
F6Q9T0_CIOIN	F7AE79_CIOIN	ENSCINP00000018150	ENSCINP00000002446	Uncharacterized protein.	SP-RING-type domain-containing protein.	0.649
F6Q9T0_CIOIN	H2XJN2_CIOIN	ENSCINP00000018150	ENSCINP00000029864	Uncharacterized protein.	RECA_2 domain-containing protein.	0.867
F6Q9T0_CIOIN	H2XL64_CIOIN	ENSCINP00000018150	ENSCINP00000030396	Uncharacterized protein.	SMC_N domain-containing protein.	0.764
F6Q9T0_CIOIN	H2XLD1_CIOIN	ENSCINP00000018150	ENSCINP00000030463	Uncharacterized protein.	Telomere_reg-2 domain-containing protein.	0.411
F6Q9T0_CIOIN	H2XN24_CIOIN	ENSCINP00000018150	ENSCINP00000031057	Uncharacterized protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.756
F6Q9T0_CIOIN	H2XNU2_CIOIN	ENSCINP00000018150	ENSCINP00000031325	Uncharacterized protein.	Uncharacterized protein.	0.704
F6Q9T0_CIOIN	H2XRC3_CIOIN	ENSCINP00000018150	ENSCINP00000032207	Uncharacterized protein.	Uncharacterized protein.	0.756
F6Q9T0_CIOIN	H2XUG9_CIOIN	ENSCINP00000018150	ENSCINP00000033303	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.594
F6Q9T0_CIOIN	H2XV49_CIOIN	ENSCINP00000018150	ENSCINP00000033533	Uncharacterized protein.	FAT domain-containing protein.	0.756
F6Q9T0_CIOIN	H2Y2T2_CIOIN	ENSCINP00000018150	ENSCINP00000036217	Uncharacterized protein.	FAT domain-containing protein.	0.835