(69 nodes) Double-strand break repair via homologous recombination network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:
	F6WGY1_CIOIN	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (246 aa)
	F6TSF1_CIOIN	DNA_pol_B domain-containing protein. (217 aa)
	Zf(cchc/grf)-1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (456 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	F7AE79_CIOIN	SP-RING-type domain-containing protein. (239 aa)
	LOC108950147	DNA helicase; Belongs to the MCM family. (798 aa)
	F6VD75_CIOIN	Uncharacterized protein. (553 aa)
	F6UM67_CIOIN	RING-type domain-containing protein. (762 aa)
	LOC100179894	Werner syndrome ATP-dependent helicase homolog isoform X1. (1194 aa)
	F6W2K0_CIOIN	DUF1767 domain-containing protein. (486 aa)
	F6QHZ5_CIOIN	FHA domain-containing protein. (234 aa)
	LOC100176679	Uncharacterized protein. (914 aa)
	F6ZYR4_CIOIN	Nipped-B protein. (723 aa)
	F6QXW9_CIOIN	Helicase ATP-binding domain-containing protein. (273 aa)
	F7BA18_CIOIN	DNA helicase; Belongs to the MCM family. (740 aa)
	LOC100187076	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (622 aa)
	F6TSV6_CIOIN	WD_REPEATS_REGION domain-containing protein. (687 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (726 aa)
	LOC100178929	Serine/threonine-protein phosphatase. (307 aa)
	F6WMK2_CIOIN	MCM domain-containing protein; Belongs to the MCM family. (817 aa)
	LOC100185652	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (530 aa)
	F6SK60_CIOIN	Uncharacterized protein. (372 aa)
	F6YHQ3_CIOIN	zf-RING-like domain-containing protein. (257 aa)
	F6UIT3_CIOIN	Uncharacterized protein. (162 aa)
	LOC100179869	Checkpoint protein; Belongs to the HUS1 family. (286 aa)
	LOC100176076	Uncharacterized protein LOC100176076. (657 aa)
	F6PXA9_CIOIN	Uncharacterized protein. (804 aa)
	F6RKM9_CIOIN	DNA helicase; Belongs to the MCM family. (820 aa)
	LOC100176589	DNA helicase; Belongs to the MCM family. (785 aa)
	F6W6L5_CIOIN	MCM domain-containing protein; Belongs to the MCM family. (422 aa)
	F6W685_CIOIN	Uncharacterized protein. (428 aa)
	LOC100181789	AAA_23 domain-containing protein. (1070 aa)
	LOC100182716	Flap endonuclease GEN homolog 1. (709 aa)
	F6WCV2_CIOIN	Protein kinase domain-containing protein. (510 aa)
	F6Q9T0_CIOIN	Uncharacterized protein. (231 aa)
	F6XHT6_CIOIN	UvrD-like helicase C-terminal domain-containing protein. (212 aa)
	F6QH43_CIOIN	RING-type domain-containing protein. (309 aa)
	F6UAB2_CIOIN	FANCM-MHF_bd domain-containing protein. (274 aa)
	F7BEK1_CIOIN	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (219 aa)
	F7AWL5_CIOIN	F-box domain-containing protein. (431 aa)
	F6YYK3_CIOIN	Uncharacterized protein. (583 aa)
	F6YY15_CIOIN	ERCC4 domain-containing protein. (826 aa)
	F6Y0T9_CIOIN	HD domain-containing protein. (481 aa)
	LOC100180856	Rad21_Rec8 domain-containing protein. (376 aa)
	F6ZKJ6_CIOIN	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (213 aa)
	F6W461_CIOIN	Uncharacterized protein. (211 aa)
	F6W3X7_CIOIN	ANK_REP_REGION domain-containing protein. (509 aa)
	F6YN96_CIOIN	3'-5' exonuclease domain-containing protein. (573 aa)
	LOC113474468	Replication protein A 14 kDa subunit-like. (118 aa)
	H2XJN2_CIOIN	RECA_2 domain-containing protein. (255 aa)
	H2XL15_CIOIN	SAE2 domain-containing protein. (153 aa)
	H2XL64_CIOIN	SMC_N domain-containing protein. (1036 aa)
	H2XLM7_CIOIN	Uncharacterized protein. (167 aa)
	LOC100179683	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	H2XN42_CIOIN	Uncharacterized protein. (362 aa)
	H2XNK1_CIOIN	Uncharacterized protein. (129 aa)
	H2XPE3_CIOIN	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
	H2XR26_CIOIN	Uncharacterized protein. (102 aa)
	H2XR45_CIOIN	Uncharacterized protein. (74 aa)
	cdc45	Uncharacterized protein. (249 aa)
	H2XT98_CIOIN	RECA_2 domain-containing protein. (265 aa)
	LOC100181925	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (328 aa)
	H2XWY1_CIOIN	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (171 aa)
	LOC100182514	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	H2XZD3_CIOIN	Uncharacterized protein. (221 aa)
	H2Y1C3_CIOIN	Uncharacterized protein. (124 aa)
	H2Y2K5_CIOIN	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (549 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	LOC100183893	Uncharacterized protein. (480 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PXA9_CIOIN	F6QHZ5_CIOIN	ENSCINP00000013050	ENSCINP00000004918	Uncharacterized protein.	FHA domain-containing protein.	0.400
F6PXA9_CIOIN	F6QXW9_CIOIN	ENSCINP00000013050	ENSCINP00000006094	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.575
F6PXA9_CIOIN	F6UAB2_CIOIN	ENSCINP00000013050	ENSCINP00000021425	Uncharacterized protein.	FANCM-MHF_bd domain-containing protein.	0.570
F6PXA9_CIOIN	H2XL15_CIOIN	ENSCINP00000013050	ENSCINP00000030347	Uncharacterized protein.	SAE2 domain-containing protein.	0.423
F6PXA9_CIOIN	H2XN42_CIOIN	ENSCINP00000013050	ENSCINP00000031075	Uncharacterized protein.	Uncharacterized protein.	0.575
F6PXA9_CIOIN	LOC100185652	ENSCINP00000013050	ENSCINP00000010283	Uncharacterized protein.	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.	0.502
F6Q9T0_CIOIN	F6QH43_CIOIN	ENSCINP00000018150	ENSCINP00000020173	Uncharacterized protein.	RING-type domain-containing protein.	0.723
F6Q9T0_CIOIN	F6QHZ5_CIOIN	ENSCINP00000018150	ENSCINP00000004918	Uncharacterized protein.	FHA domain-containing protein.	0.696
F6Q9T0_CIOIN	F6QXW9_CIOIN	ENSCINP00000018150	ENSCINP00000006094	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.992
F6Q9T0_CIOIN	F6RJ65_CIOIN	ENSCINP00000018150	ENSCINP00000001490	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.835
F6Q9T0_CIOIN	F6RKM9_CIOIN	ENSCINP00000018150	ENSCINP00000013159	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.487
F6Q9T0_CIOIN	F6SK60_CIOIN	ENSCINP00000018150	ENSCINP00000010637	Uncharacterized protein.	Uncharacterized protein.	0.544
F6Q9T0_CIOIN	F6TSF1_CIOIN	ENSCINP00000018150	ENSCINP00000000107	Uncharacterized protein.	DNA_pol_B domain-containing protein.	0.498
F6Q9T0_CIOIN	F6UAB2_CIOIN	ENSCINP00000018150	ENSCINP00000021425	Uncharacterized protein.	FANCM-MHF_bd domain-containing protein.	0.992
F6Q9T0_CIOIN	F6UIT3_CIOIN	ENSCINP00000018150	ENSCINP00000010855	Uncharacterized protein.	Uncharacterized protein.	0.681
F6Q9T0_CIOIN	F6VD75_CIOIN	ENSCINP00000018150	ENSCINP00000003159	Uncharacterized protein.	Uncharacterized protein.	0.960
F6Q9T0_CIOIN	F6W2K0_CIOIN	ENSCINP00000018150	ENSCINP00000004630	Uncharacterized protein.	DUF1767 domain-containing protein.	0.958
F6Q9T0_CIOIN	F6W685_CIOIN	ENSCINP00000018150	ENSCINP00000016062	Uncharacterized protein.	Uncharacterized protein.	0.624
F6Q9T0_CIOIN	F6W6L5_CIOIN	ENSCINP00000018150	ENSCINP00000016059	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.624
F6Q9T0_CIOIN	F6WGY1_CIOIN	ENSCINP00000018150	ENSCINP00000000037	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.932