Groups of genes that are frequently observed in each other's genomic neighborhood.
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Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100177411
RuvB-like helicase; Belongs to the RuvB family. (467 aa)
F6U609_CIOIN
Nop domain-containing protein. (533 aa)
F6RIF9_CIOIN
HIT-type domain-containing protein. (122 aa)
F6YY15_CIOIN
ERCC4 domain-containing protein. (826 aa)
Your Current Organism:
Ciona intestinalis
NCBI taxonomy Id: 7719 Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt