12 items (Ciona intestinalis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100184449	PIN2/TERF1-interacting telomerase inhibitor 1-like. (260 aa)
	F6RZ99_CIOIN	Zinc-hook domain-containing protein. (477 aa)
	LOC100187276	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (904 aa)
	F6VBZ6_CIOIN	Telo_bind domain-containing protein. (527 aa)
	H2XLD1_CIOIN	Telomere_reg-2 domain-containing protein. (689 aa)
	H2XNU2_CIOIN	Uncharacterized protein. (214 aa)
	LOC100184120	CS domain-containing protein. (193 aa)
	F6R982_CIOIN	WD_REPEATS_REGION domain-containing protein. (433 aa)
	LOC100182514	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	LOC100181113	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (198 aa)
	F6RYY5_CIOIN	AAA_23 domain-containing protein. (400 aa)
	F6U2M6_CIOIN	PUA domain-containing protein. (528 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6R982_CIOIN	F6U2M6_CIOIN	ENSCINP00000009975	ENSCINP00000009502	WD_REPEATS_REGION domain-containing protein.	PUA domain-containing protein.	0.972
F6R982_CIOIN	F6VBZ6_CIOIN	ENSCINP00000009975	ENSCINP00000027127	WD_REPEATS_REGION domain-containing protein.	Telo_bind domain-containing protein.	0.549
F6R982_CIOIN	LOC100181113	ENSCINP00000009975	ENSCINP00000011858	WD_REPEATS_REGION domain-containing protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.956
F6R982_CIOIN	LOC100187276	ENSCINP00000009975	ENSCINP00000018420	WD_REPEATS_REGION domain-containing protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.863
F6RYY5_CIOIN	F6RZ99_CIOIN	ENSCINP00000003245	ENSCINP00000003235	AAA_23 domain-containing protein.	Zinc-hook domain-containing protein.	0.900
F6RYY5_CIOIN	H2XNU2_CIOIN	ENSCINP00000003245	ENSCINP00000031325	AAA_23 domain-containing protein.	Uncharacterized protein.	0.971
F6RYY5_CIOIN	LOC100182514	ENSCINP00000003245	ENSCINP00000034174	AAA_23 domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.620
F6RYY5_CIOIN	LOC100187276	ENSCINP00000003245	ENSCINP00000018420	AAA_23 domain-containing protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.425
F6RZ99_CIOIN	F6RYY5_CIOIN	ENSCINP00000003235	ENSCINP00000003245	Zinc-hook domain-containing protein.	AAA_23 domain-containing protein.	0.900
F6RZ99_CIOIN	H2XNU2_CIOIN	ENSCINP00000003235	ENSCINP00000031325	Zinc-hook domain-containing protein.	Uncharacterized protein.	0.900
F6RZ99_CIOIN	LOC100182514	ENSCINP00000003235	ENSCINP00000034174	Zinc-hook domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.620
F6RZ99_CIOIN	LOC100187276	ENSCINP00000003235	ENSCINP00000018420	Zinc-hook domain-containing protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.425
F6U2M6_CIOIN	F6R982_CIOIN	ENSCINP00000009502	ENSCINP00000009975	PUA domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.972
F6U2M6_CIOIN	F6VBZ6_CIOIN	ENSCINP00000009502	ENSCINP00000027127	PUA domain-containing protein.	Telo_bind domain-containing protein.	0.649
F6U2M6_CIOIN	LOC100181113	ENSCINP00000009502	ENSCINP00000011858	PUA domain-containing protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.999
F6U2M6_CIOIN	LOC100187276	ENSCINP00000009502	ENSCINP00000018420	PUA domain-containing protein.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.895
F6VBZ6_CIOIN	F6R982_CIOIN	ENSCINP00000027127	ENSCINP00000009975	Telo_bind domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.549
F6VBZ6_CIOIN	F6U2M6_CIOIN	ENSCINP00000027127	ENSCINP00000009502	Telo_bind domain-containing protein.	PUA domain-containing protein.	0.649
F6VBZ6_CIOIN	LOC100181113	ENSCINP00000027127	ENSCINP00000011858	Telo_bind domain-containing protein.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.738
F6VBZ6_CIOIN	LOC100182514	ENSCINP00000027127	ENSCINP00000034174	Telo_bind domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.503