(35 nodes) Gastrulation network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	smad4	Mothers against decapentaplegic homolog. (527 aa)
	Hand	BHLH domain-containing protein. (378 aa)
	F6T5V0_CIOIN	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (481 aa)
	F6ZG18_CIOIN	FERM domain-containing protein. (589 aa)
	F6PX81_CIOIN	Plus3 domain-containing protein. (336 aa)
	LOC494392	Uncharacterized protein LOC494392. (131 aa)
	Ci-Net	Transcription factor protein. (205 aa)
	LOC100175816	TPR_REGION domain-containing protein. (1034 aa)
	F7AZD3_CIOIN	Glucose-6-phosphate isomerase; Belongs to the GPI family. (232 aa)
	F6PIT9_CIOIN	Uncharacterized protein. (210 aa)
	F6ZUE4_CIOIN	Uncharacterized protein. (292 aa)
	F6TF50_CIOIN	Uncharacterized protein. (1310 aa)
	Dusp1.2.4.5	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (434 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (304 aa)
	F6TTH0_CIOIN	Uncharacterized protein. (426 aa)
	fut13	Fut13 protein precursor. (434 aa)
	F6UMR8_CIOIN	Uncharacterized protein. (477 aa)
	F6UMH0_CIOIN	WW domain-containing protein. (284 aa)
	H2XRU0_CIOIN	Sec8_exocyst domain-containing protein. (843 aa)
	srf	Transcription factor protein. (335 aa)
	H2XU12_CIOIN	Uncharacterized protein. (189 aa)
	H2XUU5_CIOIN	Uncharacterized protein. (532 aa)
	LOC100184292	ADP-ribosylation factor-related protein 1-like. (201 aa)
	H2XW04_CIOIN	Uncharacterized protein; Belongs to the glycosyltransferase 47 family. (660 aa)
	H2XY73_CIOIN	CAP10 domain-containing protein. (119 aa)
	H2Y0L1_CIOIN	CAP10 domain-containing protein. (242 aa)
	H2Y1D3_CIOIN	Uncharacterized protein. (132 aa)
	Tgfbr-iib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)
	tgfbr-iia	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (622 aa)
	brachyury	Uncharacterized protein. (439 aa)
	nodal	Transforming growth factor beta superfamily signaling ligand isoform X1. (415 aa)
	F6R472_CIOIN	CULLIN_2 domain-containing protein; Belongs to the cullin family. (707 aa)
	LOC100179396	Integrin beta. (751 aa)
	LOC100179473	Guanine nucleotide-binding protein subunit beta-2-like 1. (323 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dusp1.2.4.5	srf	ENSCINP00000023607	ENSCINP00000032435	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transcription factor protein.	0.517
F6PIT9_CIOIN	F6TTH0_CIOIN	ENSCINP00000020211	ENSCINP00000024081	Uncharacterized protein.	Uncharacterized protein.	0.451
F6PIT9_CIOIN	H2Y1D3_CIOIN	ENSCINP00000020211	ENSCINP00000035717	Uncharacterized protein.	Uncharacterized protein.	0.451
F6PIT9_CIOIN	LOC100179396	ENSCINP00000020211	ENSCINP00000006408	Uncharacterized protein.	Integrin beta.	0.535
F6PX81_CIOIN	H2XU12_CIOIN	ENSCINP00000013055	ENSCINP00000033146	Plus3 domain-containing protein.	Uncharacterized protein.	0.440
F6PX81_CIOIN	H2XUU5_CIOIN	ENSCINP00000013055	ENSCINP00000033429	Plus3 domain-containing protein.	Uncharacterized protein.	0.972
F6PX81_CIOIN	LOC100175816	ENSCINP00000013055	ENSCINP00000018251	Plus3 domain-containing protein.	TPR_REGION domain-containing protein.	0.979
F6PX81_CIOIN	LOC494392	ENSCINP00000013055	ENSCINP00000017068	Plus3 domain-containing protein.	Uncharacterized protein LOC494392.	0.997
F6T5V0_CIOIN	F7AZD3_CIOIN	ENSCINP00000012120	ENSCINP00000019213	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.759
F6TF50_CIOIN	F6TTH0_CIOIN	ENSCINP00000023576	ENSCINP00000024081	Uncharacterized protein.	Uncharacterized protein.	0.509
F6TF50_CIOIN	F6UMH0_CIOIN	ENSCINP00000023576	ENSCINP00000025950	Uncharacterized protein.	WW domain-containing protein.	0.734
F6TF50_CIOIN	F6UMR8_CIOIN	ENSCINP00000023576	ENSCINP00000025949	Uncharacterized protein.	Uncharacterized protein.	0.734
F6TF50_CIOIN	F7AZD3_CIOIN	ENSCINP00000023576	ENSCINP00000019213	Uncharacterized protein.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.461
F6TF50_CIOIN	H2XUU5_CIOIN	ENSCINP00000023576	ENSCINP00000033429	Uncharacterized protein.	Uncharacterized protein.	0.595
F6TF50_CIOIN	H2Y1D3_CIOIN	ENSCINP00000023576	ENSCINP00000035717	Uncharacterized protein.	Uncharacterized protein.	0.509
F6TF50_CIOIN	LOC494392	ENSCINP00000023576	ENSCINP00000017068	Uncharacterized protein.	Uncharacterized protein LOC494392.	0.931
F6TTH0_CIOIN	F6PIT9_CIOIN	ENSCINP00000024081	ENSCINP00000020211	Uncharacterized protein.	Uncharacterized protein.	0.451
F6TTH0_CIOIN	F6TF50_CIOIN	ENSCINP00000024081	ENSCINP00000023576	Uncharacterized protein.	Uncharacterized protein.	0.509
F6UMH0_CIOIN	F6TF50_CIOIN	ENSCINP00000025950	ENSCINP00000023576	WW domain-containing protein.	Uncharacterized protein.	0.734
F6UMH0_CIOIN	F6UMR8_CIOIN	ENSCINP00000025950	ENSCINP00000025949	WW domain-containing protein.	Uncharacterized protein.	0.900