(62 nodes) Axon guidance network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2XPU1_CIOIN	WH1 domain-containing protein. (354 aa)
	isl	Uncharacterized protein. (402 aa)
	Ephd	Uncharacterized protein. (1048 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	F6RYL0_CIOIN	Ig-like domain-containing protein. (748 aa)
	F6UK45_CIOIN	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (860 aa)
	F6U9S1_CIOIN	RING-type domain-containing protein. (911 aa)
	LOC100181221	Integumentary mucin C.1-like. (367 aa)
	net1a	Netrin precursor. (650 aa)
	F7AWF9_CIOIN	Uncharacterized protein. (1331 aa)
	smad4	Mothers against decapentaplegic homolog. (527 aa)
	LOC100181289	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	F6WVW2_CIOIN	Uncharacterized protein. (1152 aa)
	F6SUC9_CIOIN	Uncharacterized protein. (1841 aa)
	F6UDR5_CIOIN	Uncharacterized protein. (723 aa)
	lhx3	LIM/homeobox protein Lhx3a type 1 isoform X1. (596 aa)
	LOC100177957	Tyrosine-protein kinase RYK. (593 aa)
	F6S0L5_CIOIN	Uncharacterized protein. (985 aa)
	F6Z402_CIOIN	Peptidase S72 domain-containing protein. (410 aa)
	LOC100176438	Netrin receptor UNC5B-a. (584 aa)
	F7ABT2_CIOIN	Sema domain-containing protein. (1549 aa)
	F6YQ38_CIOIN	Uncharacterized protein. (170 aa)
	F6Y677_CIOIN	Uncharacterized protein. (502 aa)
	ephrina-b	Ephrin precursor; Belongs to the ephrin family. (265 aa)
	F6ZDN3_CIOIN	Sema domain-containing protein. (427 aa)
	F6VYF2_CIOIN	Uncharacterized protein. (797 aa)
	F6SKB5_CIOIN	Uncharacterized protein. (411 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (304 aa)
	F7BNX3_CIOIN	Uncharacterized protein. (353 aa)
	F6SFW9_CIOIN	Fork-head domain-containing protein. (470 aa)
	F6YWM5_CIOIN	BHLH domain-containing protein. (96 aa)
	F6VS24_CIOIN	Sema domain-containing protein. (152 aa)
	F7BKY1_CIOIN	Sema domain-containing protein. (229 aa)
	F6QR95_CIOIN	Uncharacterized protein. (988 aa)
	Ephe	Uncharacterized protein. (1006 aa)
	LOC100180243	Uncharacterized protein. (333 aa)
	F6XAB9_CIOIN	Homeobox domain-containing protein. (171 aa)
	F6ZX31_CIOIN	Sema domain-containing protein; Belongs to the semaphorin family. (292 aa)
	F6YAS9_CIOIN	Uncharacterized protein. (601 aa)
	F6Y6P2_CIOIN	Sema domain-containing protein; Belongs to the semaphorin family. (483 aa)
	H2XJL8_CIOIN	Uncharacterized protein. (292 aa)
	H2XKM4_CIOIN	IPT/TIG domain-containing protein. (187 aa)
	H2XKP9_CIOIN	Uncharacterized protein. (329 aa)
	H2XL89_CIOIN	PHR domain-containing protein. (208 aa)
	LOC100183936	Beta-1,4-glucuronyltransferase 1 isoform X1. (427 aa)
	H2XRP4_CIOIN	Uncharacterized protein. (126 aa)
	H2XS27_CIOIN	Uncharacterized protein. (75 aa)
	H2XSG9_CIOIN	EGF-like domain-containing protein. (223 aa)
	H2XSQ8_CIOIN	Uncharacterized protein. (152 aa)
	H2XT32_CIOIN	Uncharacterized protein. (127 aa)
	H2XTQ6_CIOIN	SPOC domain-containing protein. (247 aa)
	H2XU71_CIOIN	Uncharacterized protein. (319 aa)
	H2XUP8_CIOIN	Ig-like domain-containing protein. (132 aa)
	H2XUV4_CIOIN	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (478 aa)
	ENSCINP00000033553	annotation not available (74 aa)
	H2XVV8_CIOIN	DH domain-containing protein. (1503 aa)
	H2XVY8_CIOIN	Uncharacterized protein. (331 aa)
	H2XY58_CIOIN	PHR domain-containing protein. (416 aa)
	H2XYC6_CIOIN	Uncharacterized protein. (366 aa)
	LOC100180100	Uncharacterized protein. (204 aa)
	H2Y0V6_CIOIN	Uncharacterized protein. (204 aa)
	LOC100179332	semaphorin-4G-like isoform X3; Belongs to the semaphorin family. (793 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCINP00000033553	F6UDR5_CIOIN	ENSCINP00000033553	ENSCINP00000017504	annotation not available	Uncharacterized protein.	0.540
ENSCINP00000033553	F6VS24_CIOIN	ENSCINP00000033553	ENSCINP00000024610	annotation not available	Sema domain-containing protein.	0.478
ENSCINP00000033553	F6Y6P2_CIOIN	ENSCINP00000033553	ENSCINP00000026796	annotation not available	Sema domain-containing protein; Belongs to the semaphorin family.	0.478
ENSCINP00000033553	F6ZDN3_CIOIN	ENSCINP00000033553	ENSCINP00000021279	annotation not available	Sema domain-containing protein.	0.478
ENSCINP00000033553	F6ZX31_CIOIN	ENSCINP00000033553	ENSCINP00000026069	annotation not available	Sema domain-containing protein; Belongs to the semaphorin family.	0.478
ENSCINP00000033553	F7ABT2_CIOIN	ENSCINP00000033553	ENSCINP00000019818	annotation not available	Sema domain-containing protein.	0.540
ENSCINP00000033553	F7BKY1_CIOIN	ENSCINP00000033553	ENSCINP00000024714	annotation not available	Sema domain-containing protein.	0.595
ENSCINP00000033553	LOC100179332	ENSCINP00000033553	ENSCINP00000035982	annotation not available	semaphorin-4G-like isoform X3; Belongs to the semaphorin family.	0.488
Ephd	ephrina-b	ENSCINP00000002487	ENSCINP00000020200	Uncharacterized protein.	Ephrin precursor; Belongs to the ephrin family.	0.523
Ephe	ephrina-b	ENSCINP00000025214	ENSCINP00000020200	Uncharacterized protein.	Ephrin precursor; Belongs to the ephrin family.	0.523
F6QR95_CIOIN	ephrina-b	ENSCINP00000025213	ENSCINP00000020200	Uncharacterized protein.	Ephrin precursor; Belongs to the ephrin family.	0.523
F6SFW9_CIOIN	smad4	ENSCINP00000024412	ENSCINP00000011529	Fork-head domain-containing protein.	Mothers against decapentaplegic homolog.	0.553
F6SUC9_CIOIN	F6Z402_CIOIN	ENSCINP00000016161	ENSCINP00000018986	Uncharacterized protein.	Peptidase S72 domain-containing protein.	0.970
F6SUC9_CIOIN	net1a	ENSCINP00000016161	ENSCINP00000009631	Uncharacterized protein.	Netrin precursor.	0.484
F6U9S1_CIOIN	H2XY58_CIOIN	ENSCINP00000007159	ENSCINP00000034592	RING-type domain-containing protein.	PHR domain-containing protein.	0.943
F6UDR5_CIOIN	ENSCINP00000033553	ENSCINP00000017504	ENSCINP00000033553	Uncharacterized protein.	annotation not available	0.540
F6UDR5_CIOIN	F6VS24_CIOIN	ENSCINP00000017504	ENSCINP00000024610	Uncharacterized protein.	Sema domain-containing protein.	0.478
F6UDR5_CIOIN	F6Y6P2_CIOIN	ENSCINP00000017504	ENSCINP00000026796	Uncharacterized protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.478
F6UDR5_CIOIN	F6ZDN3_CIOIN	ENSCINP00000017504	ENSCINP00000021279	Uncharacterized protein.	Sema domain-containing protein.	0.478
F6UDR5_CIOIN	F6ZX31_CIOIN	ENSCINP00000017504	ENSCINP00000026069	Uncharacterized protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.589