(44 nodes) Response to ionizing radiation network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100177452	Uncharacterized protein. (603 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	LOC104265605	Uncharacterized protein. (575 aa)
	F6UM67_CIOIN	RING-type domain-containing protein. (762 aa)
	LOC100179894	Werner syndrome ATP-dependent helicase homolog isoform X1. (1194 aa)
	LOC100176679	Uncharacterized protein. (914 aa)
	F6ZYB8_CIOIN	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	F6XMX2_CIOIN	Uncharacterized protein. (279 aa)
	LOC100186563	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	F6ZM08_CIOIN	Uncharacterized protein. (782 aa)
	F6TV58_CIOIN	Uncharacterized protein. (147 aa)
	F7ATF3_CIOIN	zf-4CXXC_R1 domain-containing protein. (286 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	F6WPB7_CIOIN	BRCC36_C domain-containing protein. (108 aa)
	LOC100175771	Cell cycle checkpoint control protein; Belongs to the rad9 family. (424 aa)
	F6WMB2_CIOIN	Uncharacterized protein. (524 aa)
	myc	Transcription factor protein isoform X1. (681 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	LOC100176674	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (278 aa)
	zf(ring)-30	Zinc finger protein. (645 aa)
	F6UCG0_CIOIN	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (943 aa)
	F6RS66_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (462 aa)
	F6QSJ0_CIOIN	Uncharacterized protein. (453 aa)
	F6QR18_CIOIN	Uncharacterized protein. (641 aa)
	LOC100187100	Lysine-specific histone demethylase 1A. (705 aa)
	LOC100186269	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (388 aa)
	F6R213_CIOIN	Uncharacterized protein. (1264 aa)
	F6Q9D5_CIOIN	Metallophos domain-containing protein. (435 aa)
	ckn1	Cockayne syndrome 1 homolog. (403 aa)
	LOC100185662	Lysine--tRNA ligase. (576 aa)
	F6UX10_CIOIN	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (655 aa)
	F6QH43_CIOIN	RING-type domain-containing protein. (309 aa)
	F7ABN7_CIOIN	F-box domain-containing protein. (241 aa)
	F6TER2_CIOIN	Protein kinase domain-containing protein. (206 aa)
	F6YVN3_CIOIN	Uncharacterized protein. (165 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	zf(ring)-23	RING-type domain-containing protein. (319 aa)
	H2XLY1_CIOIN	Uncharacterized protein. (292 aa)
	H2XN24_CIOIN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (158 aa)
	H2XNK1_CIOIN	Uncharacterized protein. (129 aa)
	H2XXZ3_CIOIN	Uncharacterized protein. (870 aa)
	H2Y1A0_CIOIN	Uncharacterized protein. (345 aa)
	H2Y1C3_CIOIN	Uncharacterized protein. (124 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QH43_CIOIN	F6R213_CIOIN	ENSCINP00000020173	ENSCINP00000018395	RING-type domain-containing protein.	Uncharacterized protein.	0.870
F6QH43_CIOIN	F6RJ65_CIOIN	ENSCINP00000020173	ENSCINP00000001490	RING-type domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.828
F6QH43_CIOIN	F6TV58_CIOIN	ENSCINP00000020173	ENSCINP00000008579	RING-type domain-containing protein.	Uncharacterized protein.	0.732
F6QH43_CIOIN	F6UCG0_CIOIN	ENSCINP00000020173	ENSCINP00000012971	RING-type domain-containing protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.692
F6QH43_CIOIN	F6UX10_CIOIN	ENSCINP00000020173	ENSCINP00000019410	RING-type domain-containing protein.	DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family.	0.534
F6QH43_CIOIN	F6WMB2_CIOIN	ENSCINP00000020173	ENSCINP00000010261	RING-type domain-containing protein.	Uncharacterized protein.	0.883
F6QH43_CIOIN	F6WPB7_CIOIN	ENSCINP00000020173	ENSCINP00000009483	RING-type domain-containing protein.	BRCC36_C domain-containing protein.	0.877
F6QH43_CIOIN	F6XMX2_CIOIN	ENSCINP00000020173	ENSCINP00000005706	RING-type domain-containing protein.	Uncharacterized protein.	0.531
F6QH43_CIOIN	F7ATF3_CIOIN	ENSCINP00000020173	ENSCINP00000009323	RING-type domain-containing protein.	zf-4CXXC_R1 domain-containing protein.	0.426
F6QH43_CIOIN	H2XLY1_CIOIN	ENSCINP00000020173	ENSCINP00000030663	RING-type domain-containing protein.	Uncharacterized protein.	0.985
F6QH43_CIOIN	H2XN24_CIOIN	ENSCINP00000020173	ENSCINP00000031057	RING-type domain-containing protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.732
F6QH43_CIOIN	H2Y1A0_CIOIN	ENSCINP00000020173	ENSCINP00000035684	RING-type domain-containing protein.	Uncharacterized protein.	0.936
F6QH43_CIOIN	H2Y2T2_CIOIN	ENSCINP00000020173	ENSCINP00000036217	RING-type domain-containing protein.	FAT domain-containing protein.	0.828
F6QH43_CIOIN	LOC100175771	ENSCINP00000020173	ENSCINP00000010009	RING-type domain-containing protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.594
F6QH43_CIOIN	LOC100177452	ENSCINP00000020173	ENSCINP00000001166	RING-type domain-containing protein.	Uncharacterized protein.	0.572
F6QH43_CIOIN	LOC100179894	ENSCINP00000020173	ENSCINP00000004562	RING-type domain-containing protein.	Werner syndrome ATP-dependent helicase homolog isoform X1.	0.966
F6QH43_CIOIN	myc	ENSCINP00000020173	ENSCINP00000010360	RING-type domain-containing protein.	Transcription factor protein isoform X1.	0.538
F6QH43_CIOIN	zf(c2h2)-102	ENSCINP00000020173	ENSCINP00000009339	RING-type domain-containing protein.	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.	0.608
F6QH43_CIOIN	zf(ring)-23	ENSCINP00000020173	ENSCINP00000029036	RING-type domain-containing protein.	RING-type domain-containing protein.	0.706
F6R213_CIOIN	F6QH43_CIOIN	ENSCINP00000018395	ENSCINP00000020173	Uncharacterized protein.	RING-type domain-containing protein.	0.870