(60 nodes) Regulation of metal ion transport network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100180604	Uncharacterized protein. (236 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (268 aa)
	H2XVF3_CIOIN	WW domain-containing protein. (200 aa)
	F6Z370_CIOIN	Uncharacterized protein. (372 aa)
	Fgf11/12/13/14	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (182 aa)
	F7A669_CIOIN	Uncharacterized protein. (157 aa)
	F7AL82_CIOIN	Uncharacterized protein. (209 aa)
	F6TT57_CIOIN	Uncharacterized protein. (762 aa)
	F6S6B2_CIOIN	Phosphoinositide phospholipase C. (1236 aa)
	H2XY78_CIOIN	Uncharacterized protein. (207 aa)
	kcnq1	Uncharacterized protein; Belongs to the potassium channel family. (520 aa)
	F6Y3N8_CIOIN	EF-hand domain-containing protein. (283 aa)
	LOC100177716	Kelch-like protein 24 isoform X1. (782 aa)
	F6V299_CIOIN	Protein kinase domain-containing protein. (523 aa)
	Sepn1	EF-hand domain-containing protein. (463 aa)
	LOC100186478	Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3-like. (208 aa)
	LOC100181289	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	F6ZXE7_CIOIN	BTB domain-containing protein. (583 aa)
	H2XYD3_CIOIN	PID domain-containing protein. (358 aa)
	F6ZD57_CIOIN	Peptidase_S9 domain-containing protein. (363 aa)
	F6ZCY0_CIOIN	DPPIV_N domain-containing protein. (389 aa)
	LOC100180112	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1106 aa)
	F6SZF9_CIOIN	Phorbol-ester/DAG-type domain-containing protein. (219 aa)
	Cibeta-catenin	Uncharacterized protein. (497 aa)
	F6SWY4_CIOIN	Uncharacterized protein. (393 aa)
	LOC100185679	Stanniocalcin-like. (237 aa)
	F6YIJ5_CIOIN	Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase. (468 aa)
	H2XYH8_CIOIN	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (88 aa)
	H2Y0Q7_CIOIN	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (185 aa)
	F6Y4X1_CIOIN	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (351 aa)
	F6R022_CIOIN	Uncharacterized protein. (309 aa)
	F6TB84_CIOIN	Uncharacterized protein. (400 aa)
	F7A675_CIOIN	Uncharacterized protein. (227 aa)
	F6VYY1_CIOIN	Protein kinase domain-containing protein. (220 aa)
	LOC100176457	Uncharacterized protein. (246 aa)
	F6VSS4_CIOIN	Uncharacterized protein. (350 aa)
	H2Y1B1_CIOIN	AKAP7_NLS domain-containing protein. (238 aa)
	LOC100178190	Calcineurin B homologous protein 1-like. (189 aa)
	H2Y204_CIOIN	Uncharacterized protein. (246 aa)
	F6PPP8_CIOIN	E3 ubiquitin-protein ligase. (871 aa)
	F6YRG2_CIOIN	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
	F6VJS2_CIOIN	SH3 domain-containing protein. (461 aa)
	F6TEI5_CIOIN	HECT domain-containing protein. (215 aa)
	F6YD53_CIOIN	Aldo_ket_red domain-containing protein. (332 aa)
	LOC100181983	PRKC apoptosis WT1 regulator protein-like. (304 aa)
	F6YVN3_CIOIN	Uncharacterized protein. (165 aa)
	F6QGN1_CIOIN	WH1 domain-containing protein. (284 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F7AR88_CIOIN	Uncharacterized protein. (229 aa)
	F6TZA7_CIOIN	Uncharacterized protein. (273 aa)
	Htt	Uncharacterized protein. (639 aa)
	F6ST26_CIOIN	Uncharacterized protein. (307 aa)
	F6Z6P7_CIOIN	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (264 aa)
	H2XKK7_CIOIN	Uncharacterized protein. (436 aa)
	H2XL48_CIOIN	Uncharacterized protein. (182 aa)
	H2XM98_CIOIN	Uncharacterized protein. (211 aa)
	H2XMJ2_CIOIN	Uncharacterized protein. (195 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	H2XMQ1_CIOIN	C2 domain-containing protein. (251 aa)
	LOC100182370	Cytochrome b-245 light chain isoform X1. (175 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cibeta-catenin	F6TZA7_CIOIN	ENSCINP00000014417	ENSCINP00000025972	Uncharacterized protein.	Uncharacterized protein.	0.963
Cibeta-catenin	F6YRG2_CIOIN	ENSCINP00000014417	ENSCINP00000002792	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.454
Cibeta-catenin	Fgf11/12/13/14	ENSCINP00000014417	ENSCINP00000008466	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.490
Cibeta-catenin	LOC100177697	ENSCINP00000014417	ENSCINP00000002782	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.521
F6R022_CIOIN	F6VSS4_CIOIN	ENSCINP00000020097	ENSCINP00000024330	Uncharacterized protein.	Uncharacterized protein.	0.513
F6TB84_CIOIN	F6YRG2_CIOIN	ENSCINP00000022039	ENSCINP00000002792	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.438
F6TB84_CIOIN	H2XL48_CIOIN	ENSCINP00000022039	ENSCINP00000030380	Uncharacterized protein.	Uncharacterized protein.	0.533
F6TB84_CIOIN	H2XM98_CIOIN	ENSCINP00000022039	ENSCINP00000030781	Uncharacterized protein.	Uncharacterized protein.	0.446
F6TZA7_CIOIN	Cibeta-catenin	ENSCINP00000025972	ENSCINP00000014417	Uncharacterized protein.	Uncharacterized protein.	0.963
F6TZA7_CIOIN	F6YRG2_CIOIN	ENSCINP00000025972	ENSCINP00000002792	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.454
F6TZA7_CIOIN	LOC100177697	ENSCINP00000025972	ENSCINP00000002782	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.521
F6V299_CIOIN	F6VYY1_CIOIN	ENSCINP00000012931	ENSCINP00000022514	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.852
F6VSS4_CIOIN	F6R022_CIOIN	ENSCINP00000024330	ENSCINP00000020097	Uncharacterized protein.	Uncharacterized protein.	0.513
F6VYY1_CIOIN	F6V299_CIOIN	ENSCINP00000022514	ENSCINP00000012931	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.852
F6Y3N8_CIOIN	F7AR88_CIOIN	ENSCINP00000011460	ENSCINP00000025727	EF-hand domain-containing protein.	Uncharacterized protein.	0.945
F6Y4X1_CIOIN	H2Y0Q7_CIOIN	ENSCINP00000019947	ENSCINP00000035491	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.943
F6YD53_CIOIN	kcnq1	ENSCINP00000005438	ENSCINP00000011044	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.600
F6YRG2_CIOIN	Cibeta-catenin	ENSCINP00000002792	ENSCINP00000014417	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.454
F6YRG2_CIOIN	F6TB84_CIOIN	ENSCINP00000002792	ENSCINP00000022039	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.438
F6YRG2_CIOIN	F6TZA7_CIOIN	ENSCINP00000002792	ENSCINP00000025972	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.454