(44 nodes) Viral process network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100186563	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	H2Y1U3_CIOIN	Protein kinase domain-containing protein. (1156 aa)
	H2XUP2_CIOIN	V-SNARE coiled-coil homology domain-containing protein. (84 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (268 aa)
	LOC104266244	Vacuolar protein sorting-associated protein VTA1 homolog. (291 aa)
	H2XPE2_CIOIN	Uncharacterized protein. (744 aa)
	LOC104265386	Uncharacterized protein. (402 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	LOC100185850	Ras-related protein ORAB-1. (204 aa)
	LOC100183075	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	Creb/atf-b	BZIP domain-containing protein. (542 aa)
	F6X1D6_CIOIN	RWD domain-containing protein. (156 aa)
	LOC100178450	Apoptosis regulatory protein Siva-like isoform X1. (164 aa)
	F6PQS1_CIOIN	Protein kinase domain-containing protein. (190 aa)
	LOC100175475	Uncharacterized protein LOC100175475 isoform X2. (654 aa)
	F7BDH1_CIOIN	BRO1 domain-containing protein. (902 aa)
	LOC100175499	WD_REPEATS_REGION domain-containing protein. (610 aa)
	LOC100179674	Vacuolar protein sorting-associated protein 37B-like. (252 aa)
	F6U8P2_CIOIN	Rab-GAP TBC domain-containing protein. (377 aa)
	LOC100175291	Uncharacterized protein LOC100175291. (180 aa)
	F6XJU3_CIOIN	Uncharacterized protein. (1922 aa)
	LOC100182343	Transcription initiation factor IIB-like. (314 aa)
	F6Z402_CIOIN	Peptidase S72 domain-containing protein. (410 aa)
	F6Q9D5_CIOIN	Metallophos domain-containing protein. (435 aa)
	F6QHM7_CIOIN	Uncharacterized protein. (725 aa)
	F6X3A4_CIOIN	Uncharacterized protein. (594 aa)
	F6X3C5_CIOIN	HA2 domain-containing protein. (413 aa)
	LOC100181512	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1186 aa)
	F7ANR5_CIOIN	CPSF_A domain-containing protein. (1145 aa)
	LOC100180144	Vacuolar protein sorting-associated protein 4B-like; Belongs to the AAA ATPase family. (438 aa)
	Zf(ring)-19	Uncharacterized protein. (722 aa)
	LOC100183161	Multivesicular body subunit 12B-like isoform X1. (248 aa)
	LOC100176751	UV radiation resistance associated protein. (760 aa)
	LOC100183816	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (306 aa)
	LOC100176174	Uncharacterized protein. (221 aa)
	LOC100181450	Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (554 aa)
	LOC100182767	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (700 aa)
	F6RCD1_CIOIN	Rab-GAP TBC domain-containing protein. (371 aa)
	F6SCE7_CIOIN	Uncharacterized protein. (361 aa)
	F6ZYB8_CIOIN	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F7BAT7_CIOIN	Prohibitin. (271 aa)
	LOC100185122	Uncharacterized protein. (863 aa)
	LOC100178236	Eukaryotic translation initiation factor 2D-like. (612 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6RCD1_CIOIN	F6U8P2_CIOIN	ENSCINP00000006334	ENSCINP00000021746	Rab-GAP TBC domain-containing protein.	Rab-GAP TBC domain-containing protein.	0.400
F6RCD1_CIOIN	LOC100185850	ENSCINP00000006334	ENSCINP00000030419	Rab-GAP TBC domain-containing protein.	Ras-related protein ORAB-1.	0.958
F6SCE7_CIOIN	F7BDH1_CIOIN	ENSCINP00000005933	ENSCINP00000023330	Uncharacterized protein.	BRO1 domain-containing protein.	0.676
F6SCE7_CIOIN	LOC100175291	ENSCINP00000005933	ENSCINP00000021680	Uncharacterized protein.	Uncharacterized protein LOC100175291.	0.923
F6SCE7_CIOIN	LOC100176174	ENSCINP00000005933	ENSCINP00000009335	Uncharacterized protein.	Uncharacterized protein.	0.923
F6SCE7_CIOIN	LOC100180144	ENSCINP00000005933	ENSCINP00000013451	Uncharacterized protein.	Vacuolar protein sorting-associated protein 4B-like; Belongs to the AAA ATPase family.	0.923
F6SCE7_CIOIN	LOC104265386	ENSCINP00000005933	ENSCINP00000031475	Uncharacterized protein.	Uncharacterized protein.	0.543
F6SCE7_CIOIN	LOC104266244	ENSCINP00000005933	ENSCINP00000031885	Uncharacterized protein.	Vacuolar protein sorting-associated protein VTA1 homolog.	0.944
F6U8P2_CIOIN	F6RCD1_CIOIN	ENSCINP00000021746	ENSCINP00000006334	Rab-GAP TBC domain-containing protein.	Rab-GAP TBC domain-containing protein.	0.400
F6X1D6_CIOIN	H2Y1U3_CIOIN	ENSCINP00000029439	ENSCINP00000035877	RWD domain-containing protein.	Protein kinase domain-containing protein.	0.899
F6X3A4_CIOIN	F6X3C5_CIOIN	ENSCINP00000015974	ENSCINP00000015971	Uncharacterized protein.	HA2 domain-containing protein.	0.944
F6X3C5_CIOIN	F6X3A4_CIOIN	ENSCINP00000015971	ENSCINP00000015974	HA2 domain-containing protein.	Uncharacterized protein.	0.944
F6ZYB8_CIOIN	LOC100186563	ENSCINP00000005699	ENSCINP00000006326	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	0.908
F7ANR5_CIOIN	LOC100183816	ENSCINP00000015292	ENSCINP00000010427	CPSF_A domain-containing protein.	Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	0.514
F7BAT7_CIOIN	atg5	ENSCINP00000001723	ENSCINP00000033358	Prohibitin.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.489
F7BDH1_CIOIN	F6SCE7_CIOIN	ENSCINP00000023330	ENSCINP00000005933	BRO1 domain-containing protein.	Uncharacterized protein.	0.676
F7BDH1_CIOIN	LOC100175291	ENSCINP00000023330	ENSCINP00000021680	BRO1 domain-containing protein.	Uncharacterized protein LOC100175291.	0.706
F7BDH1_CIOIN	LOC100176174	ENSCINP00000023330	ENSCINP00000009335	BRO1 domain-containing protein.	Uncharacterized protein.	0.614
F7BDH1_CIOIN	LOC100180144	ENSCINP00000023330	ENSCINP00000013451	BRO1 domain-containing protein.	Vacuolar protein sorting-associated protein 4B-like; Belongs to the AAA ATPase family.	0.706
F7BDH1_CIOIN	LOC100183161	ENSCINP00000023330	ENSCINP00000011486	BRO1 domain-containing protein.	Multivesicular body subunit 12B-like isoform X1.	0.927