(26 nodes) PML body network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6W9U8_CIOIN	PB1 domain-containing protein. (224 aa)
	H2Y066_CIOIN	Uncharacterized protein. (361 aa)
	LOC100182514	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	H2XWT8_CIOIN	Uncharacterized protein. (206 aa)
	LOC100175581	Uncharacterized protein LOC100175581. (186 aa)
	H2XQ41_CIOIN	UDG domain-containing protein. (250 aa)
	H2XN24_CIOIN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (158 aa)
	H2XM17_CIOIN	FAT domain-containing protein. (187 aa)
	H2XL64_CIOIN	SMC_N domain-containing protein. (1036 aa)
	H2XJT4_CIOIN	PHD-type domain-containing protein. (508 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	F6ZWQ3_CIOIN	Uncharacterized protein. (215 aa)
	LOC100184598	Sequestosome-1 isoform X1. (329 aa)
	LOC100181789	AAA_23 domain-containing protein. (1070 aa)
	LOC100182651	E3 ubiquitin-protein ligase RNF4 isoform X1. (224 aa)
	LOC100184540	Death domain-associated protein 6-like isoform X1. (234 aa)
	F6WMB2_CIOIN	Uncharacterized protein. (524 aa)
	F6YGJ7_CIOIN	Uncharacterized protein; Belongs to the peptidase C19 family. (1099 aa)
	F6TV58_CIOIN	Uncharacterized protein. (147 aa)
	F6SM21_CIOIN	BTB domain-containing protein. (601 aa)
	F6PL57_CIOIN	Uncharacterized protein. (1087 aa)
	F6UM67_CIOIN	RING-type domain-containing protein. (762 aa)
	F6VK85_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (754 aa)
	F7AE79_CIOIN	SP-RING-type domain-containing protein. (239 aa)
	F7AS59_CIOIN	SprT-like domain-containing protein. (197 aa)
	Zf(cchc/grf)-1	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (456 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PL57_CIOIN	LOC100181789	ENSCINP00000006244	ENSCINP00000016652	Uncharacterized protein.	AAA_23 domain-containing protein.	0.471
F6PL57_CIOIN	LOC100184540	ENSCINP00000006244	ENSCINP00000011909	Uncharacterized protein.	Death domain-associated protein 6-like isoform X1.	0.930
F6SM21_CIOIN	F6W9U8_CIOIN	ENSCINP00000008089	ENSCINP00000002565	BTB domain-containing protein.	PB1 domain-containing protein.	0.503
F6SM21_CIOIN	LOC100175581	ENSCINP00000008089	ENSCINP00000033899	BTB domain-containing protein.	Uncharacterized protein LOC100175581.	0.503
F6SM21_CIOIN	LOC100184598	ENSCINP00000008089	ENSCINP00000023991	BTB domain-containing protein.	Sequestosome-1 isoform X1.	0.505
F6TV58_CIOIN	F6WMB2_CIOIN	ENSCINP00000008579	ENSCINP00000010261	Uncharacterized protein.	Uncharacterized protein.	0.719
F6TV58_CIOIN	H2XN24_CIOIN	ENSCINP00000008579	ENSCINP00000031057	Uncharacterized protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.938
F6TV58_CIOIN	LOC100181789	ENSCINP00000008579	ENSCINP00000016652	Uncharacterized protein.	AAA_23 domain-containing protein.	0.437
F6TV58_CIOIN	LOC100182514	ENSCINP00000008579	ENSCINP00000034174	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.769
F6TV58_CIOIN	Zf(cchc/grf)-1	ENSCINP00000008579	ENSCINP00000000640	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.497
F6UM67_CIOIN	LOC100182514	ENSCINP00000003190	ENSCINP00000034174	RING-type domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.890
F6VK85_CIOIN	H2XM17_CIOIN	ENSCINP00000002868	ENSCINP00000030699	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.943
F6VK85_CIOIN	H2XWT8_CIOIN	ENSCINP00000002868	ENSCINP00000034122	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.925
F6VK85_CIOIN	H2Y066_CIOIN	ENSCINP00000002868	ENSCINP00000035300	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.929
F6W9U8_CIOIN	F6SM21_CIOIN	ENSCINP00000002565	ENSCINP00000008089	PB1 domain-containing protein.	BTB domain-containing protein.	0.503
F6W9U8_CIOIN	LOC100184598	ENSCINP00000002565	ENSCINP00000023991	PB1 domain-containing protein.	Sequestosome-1 isoform X1.	0.909
F6WMB2_CIOIN	F6TV58_CIOIN	ENSCINP00000010261	ENSCINP00000008579	Uncharacterized protein.	Uncharacterized protein.	0.719
F6WMB2_CIOIN	H2XL64_CIOIN	ENSCINP00000010261	ENSCINP00000030396	Uncharacterized protein.	SMC_N domain-containing protein.	0.466
F6WMB2_CIOIN	H2XN24_CIOIN	ENSCINP00000010261	ENSCINP00000031057	Uncharacterized protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.719
F6WMB2_CIOIN	LOC100181789	ENSCINP00000010261	ENSCINP00000016652	Uncharacterized protein.	AAA_23 domain-containing protein.	0.502