(34 nodes) Nuclear receptor binding network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	Zf(c2h2)-117	Uncharacterized protein. (1015 aa)
	ekn1	EKN1 protein. (434 aa)
	nr41/42/43	Uncharacterized protein. (1053 aa)
	H2XJY9_CIOIN	Uncharacterized protein. (192 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	F6RIY5_CIOIN	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (814 aa)
	F7BQ10_CIOIN	ASCH domain-containing protein. (146 aa)
	LOC100175435	Uncharacterized protein LOC100175435. (268 aa)
	Ci-FXR	Nuclear receptor. (294 aa)
	F6Y8T6_CIOIN	TAFII55_N domain-containing protein. (166 aa)
	LOC100177488	Protein BUD31 homolog. (144 aa)
	F6ZGS0_CIOIN	TMF_TATA_bd domain-containing protein. (317 aa)
	F6V3W8_CIOIN	Uncharacterized protein. (264 aa)
	F7AQ56_CIOIN	Uncharacterized protein. (229 aa)
	LOC100182343	Transcription initiation factor IIB-like. (314 aa)
	Nr-like	Nuclear receptor domain-containing protein. (657 aa)
	F7BBD1_CIOIN	Uncharacterized protein. (2317 aa)
	LOC100176856	Uncharacterized protein. (956 aa)
	Q1RL49_CIOIN	RBR-type E3 ubiquitin transferase. (455 aa)
	LOC100183284	SKIP_SNW domain-containing protein. (534 aa)
	F6PIY6_CIOIN	GPS2_interact domain-containing protein. (373 aa)
	F6XT34_CIOIN	HMG box domain-containing protein. (405 aa)
	F6YIR9_CIOIN	LisH domain-containing protein. (1416 aa)
	F6YJ10_CIOIN	Uncharacterized protein. (962 aa)
	F7B7U2_CIOIN	Bromo domain-containing protein. (440 aa)
	F6Y836_CIOIN	Uncharacterized protein. (557 aa)
	LOC100187100	Lysine-specific histone demethylase 1A. (705 aa)
	LOC100184540	Death domain-associated protein 6-like isoform X1. (234 aa)
	LOC100183873	WD_REPEATS_REGION domain-containing protein. (447 aa)
	F6RMT1_CIOIN	Uncharacterized protein. (551 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
	F7AUL7_CIOIN	Uncharacterized protein. (989 aa)
	F7BPY2_CIOIN	zf-C2HC5 domain-containing protein. (328 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ci-FXR	F6PIY6_CIOIN	ENSCINP00000007492	ENSCINP00000016774	Nuclear receptor.	GPS2_interact domain-containing protein.	0.844
Ci-FXR	H2Y0R6_CIOIN	ENSCINP00000007492	ENSCINP00000035500	Nuclear receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.623
Ci-FXR	H2Y2G5_CIOIN	ENSCINP00000007492	ENSCINP00000036100	Nuclear receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.623
F6PIY6_CIOIN	Ci-FXR	ENSCINP00000016774	ENSCINP00000007492	GPS2_interact domain-containing protein.	Nuclear receptor.	0.844
F6PIY6_CIOIN	F6SLD6_CIOIN	ENSCINP00000016774	ENSCINP00000027486	GPS2_interact domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.752
F6PIY6_CIOIN	F6Y836_CIOIN	ENSCINP00000016774	ENSCINP00000014778	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.839
F6PIY6_CIOIN	H2Y0R6_CIOIN	ENSCINP00000016774	ENSCINP00000035500	GPS2_interact domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.506
F6PIY6_CIOIN	H2Y2G5_CIOIN	ENSCINP00000016774	ENSCINP00000036100	GPS2_interact domain-containing protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.506
F6PIY6_CIOIN	LOC100175435	ENSCINP00000016774	ENSCINP00000007849	GPS2_interact domain-containing protein.	Uncharacterized protein LOC100175435.	0.600
F6PIY6_CIOIN	LOC100183284	ENSCINP00000016774	ENSCINP00000017139	GPS2_interact domain-containing protein.	SKIP_SNW domain-containing protein.	0.732
F6PIY6_CIOIN	Nr-like	ENSCINP00000016774	ENSCINP00000019512	GPS2_interact domain-containing protein.	Nuclear receptor domain-containing protein.	0.542
F6PIY6_CIOIN	nr41/42/43	ENSCINP00000016774	ENSCINP00000030359	GPS2_interact domain-containing protein.	Uncharacterized protein.	0.542
F6RIY5_CIOIN	F6RMT1_CIOIN	ENSCINP00000025446	ENSCINP00000009626	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Uncharacterized protein.	0.476
F6RIY5_CIOIN	LOC100176856	ENSCINP00000025446	ENSCINP00000017945	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	Uncharacterized protein.	0.457
F6RIY5_CIOIN	LOC100183873	ENSCINP00000025446	ENSCINP00000010883	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.601
F6RMT1_CIOIN	F6RIY5_CIOIN	ENSCINP00000009626	ENSCINP00000025446	Uncharacterized protein.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.476
F6RMT1_CIOIN	F6Y8T6_CIOIN	ENSCINP00000009626	ENSCINP00000007361	Uncharacterized protein.	TAFII55_N domain-containing protein.	0.782
F6RMT1_CIOIN	F6YJ10_CIOIN	ENSCINP00000009626	ENSCINP00000015307	Uncharacterized protein.	Uncharacterized protein.	0.497
F6RMT1_CIOIN	H2Y0R6_CIOIN	ENSCINP00000009626	ENSCINP00000035500	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.410
F6RMT1_CIOIN	H2Y2G5_CIOIN	ENSCINP00000009626	ENSCINP00000036100	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.410