(52 nodes) Second-messenger-mediated signaling network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100187498	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (624 aa)
	F6TEA7_CIOIN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (587 aa)
	LOC100178591	Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (518 aa)
	F6PHN1_CIOIN	Protein kinase domain-containing protein. (1026 aa)
	F6S6B2_CIOIN	Phosphoinositide phospholipase C. (1236 aa)
	creb/atf-c	Transcription factor Ci-CREB/ATF-c isoform X1. (298 aa)
	F6TXZ0_CIOIN	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1047 aa)
	LOC100176674	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (278 aa)
	F6PR01_CIOIN	PKD_channel domain-containing protein. (558 aa)
	F6QW33_CIOIN	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (316 aa)
	F6YKH7_CIOIN	Uncharacterized protein. (1937 aa)
	LOC100178482	Uncharacterized protein. (180 aa)
	F6X4F9_CIOIN	Uncharacterized protein. (262 aa)
	F6QHM7_CIOIN	Uncharacterized protein. (725 aa)
	F6YD09_CIOIN	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (608 aa)
	Cam	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
	F6QX80_CIOIN	DAGKc domain-containing protein. (374 aa)
	Mist	BHLH domain-containing protein. (550 aa)
	F6TK42_CIOIN	Guanylate cyclase domain-containing protein. (223 aa)
	zf(c2h2)-60	Uncharacterized protein. (425 aa)
	F6Y940_CIOIN	Serine/threonine-protein phosphatase. (241 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	F6YHV1_CIOIN	Cyclic nucleotide-binding domain-containing protein. (200 aa)
	F6ZQL1_CIOIN	HNOB domain-containing protein. (201 aa)
	F6V542_CIOIN	Uncharacterized protein. (159 aa)
	LOC100184110	Hippocalcin-like protein 1. (194 aa)
	F6QGN1_CIOIN	WH1 domain-containing protein. (284 aa)
	F6RPN1_CIOIN	G_PROTEIN_RECEP_F3_4 domain-containing protein. (737 aa)
	F6UYT5_CIOIN	AC_N domain-containing protein. (314 aa)
	LOC100176472	Uncharacterized protein. (192 aa)
	F6Z6P7_CIOIN	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (264 aa)
	H2XK39_CIOIN	Protein kinase domain-containing protein. (998 aa)
	H2XLJ9_CIOIN	Uncharacterized protein. (177 aa)
	H2XMM7_CIOIN	Uncharacterized protein. (200 aa)
	H2XN97_CIOIN	Uncharacterized protein. (200 aa)
	H2XNS0_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein. (272 aa)
	H2XPA3_CIOIN	Ras-GEF domain-containing protein. (451 aa)
	H2XPE2_CIOIN	Uncharacterized protein. (744 aa)
	H2XSF3_CIOIN	Uncharacterized protein. (5075 aa)
	H2XUD7_CIOIN	Uncharacterized protein. (223 aa)
	H2XV34_CIOIN	Uncharacterized protein. (117 aa)
	H2XXP3_CIOIN	Uncharacterized protein. (123 aa)
	H2XXY5_CIOIN	Ion_trans domain-containing protein. (456 aa)
	H2XYH8_CIOIN	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (88 aa)
	H2XYN3_CIOIN	DAGKa domain-containing protein. (184 aa)
	H2XZF1_CIOIN	PDZ domain-containing protein. (205 aa)
	LOC100187330	Calcineurin subunit B type 1. (170 aa)
	H2Y004_CIOIN	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (232 aa)
	H2Y0S2_CIOIN	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (221 aa)
	H2Y0S5_CIOIN	RHD_dimer domain-containing protein. (378 aa)
	H2Y1G2_CIOIN	Uncharacterized protein. (310 aa)
	H2Y3B3_CIOIN	Ion_trans domain-containing protein. (219 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cam	F6Y940_CIOIN	ENSCINP00000017572	ENSCINP00000021645	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Serine/threonine-protein phosphatase.	0.492
Cam	H2XSF3_CIOIN	ENSCINP00000017572	ENSCINP00000032587	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.565
Cam	H2XV34_CIOIN	ENSCINP00000017572	ENSCINP00000033518	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Uncharacterized protein.	0.492
F6PR01_CIOIN	F6TXZ0_CIOIN	ENSCINP00000013096	ENSCINP00000010301	PKD_channel domain-containing protein.	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	0.419
F6PR01_CIOIN	H2XLJ9_CIOIN	ENSCINP00000013096	ENSCINP00000030531	PKD_channel domain-containing protein.	Uncharacterized protein.	0.741
F6PR01_CIOIN	H2Y3B3_CIOIN	ENSCINP00000013096	ENSCINP00000036398	PKD_channel domain-containing protein.	Ion_trans domain-containing protein.	0.631
F6QW33_CIOIN	F6TEA7_CIOIN	ENSCINP00000013533	ENSCINP00000004417	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.728
F6QW33_CIOIN	F6TK42_CIOIN	ENSCINP00000013533	ENSCINP00000019454	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein.	0.728
F6QW33_CIOIN	H2Y0S2_CIOIN	ENSCINP00000013533	ENSCINP00000035506	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.908
F6QW33_CIOIN	LOC100178591	ENSCINP00000013533	ENSCINP00000004523	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.755
F6QW33_CIOIN	LOC100187498	ENSCINP00000013533	ENSCINP00000003264	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.728
F6QX80_CIOIN	H2XYN3_CIOIN	ENSCINP00000018087	ENSCINP00000034767	DAGKc domain-containing protein.	DAGKa domain-containing protein.	0.949
F6S6B2_CIOIN	F6YKH7_CIOIN	ENSCINP00000009002	ENSCINP00000015035	Phosphoinositide phospholipase C.	Uncharacterized protein.	0.426
F6S6B2_CIOIN	H2XXY5_CIOIN	ENSCINP00000009002	ENSCINP00000034519	Phosphoinositide phospholipase C.	Ion_trans domain-containing protein.	0.422
F6S6B2_CIOIN	H2Y0S5_CIOIN	ENSCINP00000009002	ENSCINP00000035509	Phosphoinositide phospholipase C.	RHD_dimer domain-containing protein.	0.408
F6TEA7_CIOIN	F6QW33_CIOIN	ENSCINP00000004417	ENSCINP00000013533	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.728
F6TEA7_CIOIN	F6TK42_CIOIN	ENSCINP00000004417	ENSCINP00000019454	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.566
F6TEA7_CIOIN	F6YD09_CIOIN	ENSCINP00000004417	ENSCINP00000017414	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.586
F6TEA7_CIOIN	H2Y0S2_CIOIN	ENSCINP00000004417	ENSCINP00000035506	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.728
F6TEA7_CIOIN	LOC100178591	ENSCINP00000004417	ENSCINP00000004523	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase soluble subunit alpha-2 isoform X2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.919