(29 nodes) Clathrin-coated vesicle membrane network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Vachtp	MFS domain-containing protein. (657 aa)
	LOC100176424	V-type proton ATPase subunit D-like. (255 aa)
	F6SPL0_CIOIN	Uncharacterized protein. (503 aa)
	F7A6N9_CIOIN	Uncharacterized protein. (480 aa)
	F6RXW9_CIOIN	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (158 aa)
	LOC100182553	AP-2 complex subunit mu isoform X3; Belongs to the adaptor complexes medium subunit family. (434 aa)
	LOC100178823	V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (474 aa)
	F6UP73_CIOIN	ENTH domain-containing protein. (222 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	LOC101242403	Uncharacterized protein LOC101242403 isoform X1. (410 aa)
	LOC100176522	AP-1 complex subunit gamma. (888 aa)
	LOC100181913	V-type proton ATPase 21 kDa proteolipid subunit; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
	LOC100181883	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1057 aa)
	LOC100185647	Uncharacterized protein. (525 aa)
	F7ABF6_CIOIN	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (954 aa)
	F6Z0L2_CIOIN	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (235 aa)
	F6ZH66_CIOIN	ENTH domain-containing protein. (243 aa)
	F6RPM3_CIOIN	Clathrin_bdg domain-containing protein. (357 aa)
	F6QV69_CIOIN	TSNAXIP1_N domain-containing protein. (350 aa)
	H2XLC2_CIOIN	AP complex subunit beta. (772 aa)
	LOC100187027	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	H2XRE1_CIOIN	DUF1681 domain-containing protein. (215 aa)
	LOC100178401	Uncharacterized protein. (250 aa)
	H2XZK4_CIOIN	B2-adapt-app_C domain-containing protein. (146 aa)
	H2Y0X3_CIOIN	MFS domain-containing protein. (144 aa)
	LOC100180959	Receptor expression-enhancing protein. (201 aa)
	F6YCG7_CIOIN	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1086 aa)
	F6W8X6_CIOIN	Uncharacterized protein. (248 aa)
	F7AMF6_CIOIN	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1635 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QV69_CIOIN	F6UMA7_CIOIN	ENSCINP00000025525	ENSCINP00000015165	TSNAXIP1_N domain-containing protein.	PID domain-containing protein.	0.492
F6QV69_CIOIN	F6UP73_CIOIN	ENSCINP00000025525	ENSCINP00000013607	TSNAXIP1_N domain-containing protein.	ENTH domain-containing protein.	0.753
F6QV69_CIOIN	F6Z0L2_CIOIN	ENSCINP00000025525	ENSCINP00000022714	TSNAXIP1_N domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.944
F6QV69_CIOIN	F6ZH66_CIOIN	ENSCINP00000025525	ENSCINP00000024211	TSNAXIP1_N domain-containing protein.	ENTH domain-containing protein.	0.719
F6QV69_CIOIN	F7A6N9_CIOIN	ENSCINP00000025525	ENSCINP00000010183	TSNAXIP1_N domain-containing protein.	Uncharacterized protein.	0.557
F6QV69_CIOIN	H2XLC2_CIOIN	ENSCINP00000025525	ENSCINP00000030454	TSNAXIP1_N domain-containing protein.	AP complex subunit beta.	0.799
F6QV69_CIOIN	H2XRE1_CIOIN	ENSCINP00000025525	ENSCINP00000032225	TSNAXIP1_N domain-containing protein.	DUF1681 domain-containing protein.	0.609
F6QV69_CIOIN	H2XZK4_CIOIN	ENSCINP00000025525	ENSCINP00000035088	TSNAXIP1_N domain-containing protein.	B2-adapt-app_C domain-containing protein.	0.799
F6QV69_CIOIN	LOC100176522	ENSCINP00000025525	ENSCINP00000016410	TSNAXIP1_N domain-containing protein.	AP-1 complex subunit gamma.	0.759
F6QV69_CIOIN	LOC100178401	ENSCINP00000025525	ENSCINP00000032831	TSNAXIP1_N domain-containing protein.	Uncharacterized protein.	0.753
F6QV69_CIOIN	LOC100181883	ENSCINP00000025525	ENSCINP00000018009	TSNAXIP1_N domain-containing protein.	AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.	0.587
F6QV69_CIOIN	LOC100182553	ENSCINP00000025525	ENSCINP00000010860	TSNAXIP1_N domain-containing protein.	AP-2 complex subunit mu isoform X3; Belongs to the adaptor complexes medium subunit family.	0.781
F6QV69_CIOIN	LOC100187027	ENSCINP00000025525	ENSCINP00000030539	TSNAXIP1_N domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.761
F6RPM3_CIOIN	F6UP73_CIOIN	ENSCINP00000025415	ENSCINP00000013607	Clathrin_bdg domain-containing protein.	ENTH domain-containing protein.	0.540
F6RPM3_CIOIN	F6Z0L2_CIOIN	ENSCINP00000025415	ENSCINP00000022714	Clathrin_bdg domain-containing protein.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.561
F6RPM3_CIOIN	F7A6N9_CIOIN	ENSCINP00000025415	ENSCINP00000010183	Clathrin_bdg domain-containing protein.	Uncharacterized protein.	0.752
F6RPM3_CIOIN	F7ABF6_CIOIN	ENSCINP00000025415	ENSCINP00000019822	Clathrin_bdg domain-containing protein.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.540
F6RPM3_CIOIN	F7AMF6_CIOIN	ENSCINP00000025415	ENSCINP00000003530	Clathrin_bdg domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.579
F6RPM3_CIOIN	H2XRE1_CIOIN	ENSCINP00000025415	ENSCINP00000032225	Clathrin_bdg domain-containing protein.	DUF1681 domain-containing protein.	0.540
F6RPM3_CIOIN	LOC100176522	ENSCINP00000025415	ENSCINP00000016410	Clathrin_bdg domain-containing protein.	AP-1 complex subunit gamma.	0.622