(11 nodes) Receptor internalization network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6WAT8_CIOIN	Protein kinase domain-containing protein. (754 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6YRG2_CIOIN	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
	F7AMF6_CIOIN	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1635 aa)
	F6VF77_CIOIN	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
	zf(fyve)-11	Uncharacterized protein. (717 aa)
	F6U617_CIOIN	Uncharacterized protein. (239 aa)
	F6XZX9_CIOIN	Uncharacterized protein. (263 aa)
	LOC100187429	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (160 aa)
	Ciarr	Arrestin_C domain-containing protein. (253 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ciarr	F6VF77_CIOIN	ENSCINP00000029120	ENSCINP00000004680	Arrestin_C domain-containing protein.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.595
Ciarr	F7AMF6_CIOIN	ENSCINP00000029120	ENSCINP00000003530	Arrestin_C domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.960
F6U617_CIOIN	F6XZX9_CIOIN	ENSCINP00000023269	ENSCINP00000001884	Uncharacterized protein.	Uncharacterized protein.	0.522
F6VF77_CIOIN	Ciarr	ENSCINP00000004680	ENSCINP00000029120	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Arrestin_C domain-containing protein.	0.595
F6VF77_CIOIN	F6YRG2_CIOIN	ENSCINP00000004680	ENSCINP00000002792	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.608
F6VF77_CIOIN	F7AMF6_CIOIN	ENSCINP00000004680	ENSCINP00000003530	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.831
F6VF77_CIOIN	LOC100177697	ENSCINP00000004680	ENSCINP00000002782	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.751
F6VF77_CIOIN	LOC100178517	ENSCINP00000004680	ENSCINP00000030917	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.523
F6VF77_CIOIN	zf(fyve)-11	ENSCINP00000004680	ENSCINP00000013389	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Uncharacterized protein.	0.421
F6XZX9_CIOIN	F6U617_CIOIN	ENSCINP00000001884	ENSCINP00000023269	Uncharacterized protein.	Uncharacterized protein.	0.522
F6YRG2_CIOIN	F6VF77_CIOIN	ENSCINP00000002792	ENSCINP00000004680	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.608
F6YRG2_CIOIN	LOC100177697	ENSCINP00000002792	ENSCINP00000002782	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.494
F6YRG2_CIOIN	LOC100178517	ENSCINP00000002792	ENSCINP00000030917	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.491
F7AMF6_CIOIN	Ciarr	ENSCINP00000003530	ENSCINP00000029120	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Arrestin_C domain-containing protein.	0.960
F7AMF6_CIOIN	F6VF77_CIOIN	ENSCINP00000003530	ENSCINP00000004680	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.831
F7AMF6_CIOIN	LOC100177697	ENSCINP00000003530	ENSCINP00000002782	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.433
F7AMF6_CIOIN	zf(fyve)-11	ENSCINP00000003530	ENSCINP00000013389	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.891
LOC100177697	F6VF77_CIOIN	ENSCINP00000002782	ENSCINP00000004680	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.751
LOC100177697	F6YRG2_CIOIN	ENSCINP00000002782	ENSCINP00000002792	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.494
LOC100177697	F7AMF6_CIOIN	ENSCINP00000002782	ENSCINP00000003530	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.433