(72 nodes) Positive regulation of response to external stimulus network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	LOC100177452	Uncharacterized protein. (603 aa)
	LOC100176290	Uncharacterized protein LOC100176290 isoform X4. (787 aa)
	F7B0D1_CIOIN	GH16 domain-containing protein. (237 aa)
	F6YKS6_CIOIN	Uncharacterized protein. (1773 aa)
	F6RZT0_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (262 aa)
	LOC100176571	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (198 aa)
	LOC104265809	Polyglutamine-binding protein 1-like. (208 aa)
	F6TBE2_CIOIN	Uncharacterized protein. (444 aa)
	F6U899_CIOIN	DJ-1_PfpI domain-containing protein. (187 aa)
	F6WUP4_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	LOC100184817	Growth hormone secretagogue receptor type 1-like. (366 aa)
	F6TAK3_CIOIN	PUM-HD domain-containing protein. (782 aa)
	F6RWR9_CIOIN	Uncharacterized protein. (533 aa)
	LOC100179839	Sorting nexin-4-like. (441 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	F7A9G9_CIOIN	RING-type domain-containing protein. (966 aa)
	F6PMK8_CIOIN	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (710 aa)
	F6PLR6_CIOIN	Uncharacterized protein. (176 aa)
	F6R946_CIOIN	Uncharacterized protein. (246 aa)
	F7B9G3_CIOIN	TGF_BETA_2 domain-containing protein. (387 aa)
	LOC104265788	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (199 aa)
	ikk-epsilon	ikappaB kinase isoform X1. (797 aa)
	F6SDP7_CIOIN	EGF-like domain-containing protein. (628 aa)
	F6V299_CIOIN	Protein kinase domain-containing protein. (523 aa)
	Zf(ring)-19	Uncharacterized protein. (722 aa)
	F6RJ81_CIOIN	ANK_REP_REGION domain-containing protein. (400 aa)
	F6QP05_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein. (291 aa)
	F6UN86_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (477 aa)
	F6ZVH0_CIOIN	Uncharacterized protein. (205 aa)
	F6ZVG1_CIOIN	Uncharacterized protein; Belongs to the RNA polymerase beta chain family. (275 aa)
	LOC104266675	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (226 aa)
	F6VXC2_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (262 aa)
	LOC100184400	DNA-directed RNA polymerase III subunit RPC4. (349 aa)
	F7BJS1_CIOIN	GH16 domain-containing protein. (554 aa)
	F6QY33_CIOIN	Uncharacterized protein. (379 aa)
	F6R6J0_CIOIN	Uncharacterized protein. (585 aa)
	gla1	Uncharacterized protein LOC780869. (554 aa)
	F6Y9D9_CIOIN	Uncharacterized protein. (768 aa)
	LOC100185662	Lysine--tRNA ligase. (576 aa)
	LOC100180168	Protein LSM14 homolog A-B isoform X1. (518 aa)
	LOC100182077	TNFAIP3-interacting protein 1 isoform X2. (729 aa)
	F6PI16_CIOIN	Uncharacterized protein. (234 aa)
	F6UAD5_CIOIN	GH16 domain-containing protein. (205 aa)
	LOC100185968	Caspase-6-like isoform X1; Belongs to the peptidase C14A family. (279 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	F7AAV2_CIOIN	EGF-like domain-containing protein. (618 aa)
	F6V7C2_CIOIN	Protein kinase domain-containing protein. (521 aa)
	F6V5K2_CIOIN	Uncharacterized protein. (467 aa)
	F6SYE0_CIOIN	Protein kinase domain-containing protein. (216 aa)
	F6SWJ9_CIOIN	Uncharacterized protein. (130 aa)
	F6T8R8_CIOIN	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (311 aa)
	LOC100185535	Motile sperm domain-containing protein 2. (246 aa)
	F7AIB9_CIOIN	Uncharacterized protein. (271 aa)
	Creb/atf-b	BZIP domain-containing protein. (542 aa)
	H2XLY8_CIOIN	SEFIR domain-containing protein. (769 aa)
	Q1RPY5_CIOIN	Zinc finger protein. (579 aa)
	H2XN90_CIOIN	Uncharacterized protein. (224 aa)
	LOC100182370	Cytochrome b-245 light chain isoform X1. (175 aa)
	H2XNS0_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein. (272 aa)
	H2XP40_CIOIN	RNA_pol_Rpb2_1 domain-containing protein. (178 aa)
	H2XR13_CIOIN	RNA_pol_Rpb2_6 domain-containing protein. (135 aa)
	H2XUP2_CIOIN	V-SNARE coiled-coil homology domain-containing protein. (84 aa)
	H2XXT8_CIOIN	Uncharacterized protein. (189 aa)
	H2Y0K8_CIOIN	Uncharacterized protein. (467 aa)
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	H2Y1T8_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein. (149 aa)
	H2Y1X7_CIOIN	Uncharacterized protein. (191 aa)
	LOC100182428	NF-kappa-B inhibitor zeta-like isoform X1. (649 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
	H2Y2R4_CIOIN	Uncharacterized protein. (167 aa)
	H2Y2V4_CIOIN	Protein kinase domain-containing protein. (209 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PMK8_CIOIN	F6ZLD5_CIOIN	ENSCINP00000009846	ENSCINP00000022439	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Protein kinase domain-containing protein.	0.595
F6PMK8_CIOIN	H2XUP2_CIOIN	ENSCINP00000009846	ENSCINP00000033376	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	V-SNARE coiled-coil homology domain-containing protein.	0.446
F6PMK8_CIOIN	LOC100179839	ENSCINP00000009846	ENSCINP00000009207	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Sorting nexin-4-like.	0.420
F6RJ81_CIOIN	H2Y2R4_CIOIN	ENSCINP00000013468	ENSCINP00000036199	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.900
F6SDP7_CIOIN	F7AAV2_CIOIN	ENSCINP00000012732	ENSCINP00000023392	EGF-like domain-containing protein.	EGF-like domain-containing protein.	0.902
F6SWJ9_CIOIN	LOC104266675	ENSCINP00000026601	ENSCINP00000015202	Uncharacterized protein.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.450
F6SYE0_CIOIN	F7A9G9_CIOIN	ENSCINP00000026311	ENSCINP00000009356	Protein kinase domain-containing protein.	RING-type domain-containing protein.	0.717
F6SYE0_CIOIN	Q1RPY5_CIOIN	ENSCINP00000026311	ENSCINP00000030768	Protein kinase domain-containing protein.	Zinc finger protein.	0.808
F6SYE0_CIOIN	ikk-epsilon	ENSCINP00000026311	ENSCINP00000011687	Protein kinase domain-containing protein.	ikappaB kinase isoform X1.	0.777
F6T8R8_CIOIN	F6ZVG1_CIOIN	ENSCINP00000027447	ENSCINP00000014455	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	Uncharacterized protein; Belongs to the RNA polymerase beta chain family.	0.828
F6T8R8_CIOIN	F6ZVH0_CIOIN	ENSCINP00000027447	ENSCINP00000014454	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	Uncharacterized protein.	0.828
F6T8R8_CIOIN	H2XP40_CIOIN	ENSCINP00000027447	ENSCINP00000031423	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	RNA_pol_Rpb2_1 domain-containing protein.	0.828
F6T8R8_CIOIN	H2XR13_CIOIN	ENSCINP00000027447	ENSCINP00000032097	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	RNA_pol_Rpb2_6 domain-containing protein.	0.828
F6T8R8_CIOIN	LOC100184400	ENSCINP00000027447	ENSCINP00000016627	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.	DNA-directed RNA polymerase III subunit RPC4.	0.998
F6TBE2_CIOIN	LOC104266675	ENSCINP00000006801	ENSCINP00000015202	Uncharacterized protein.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.669
F6U899_CIOIN	F6ZLD5_CIOIN	ENSCINP00000007465	ENSCINP00000022439	DJ-1_PfpI domain-containing protein.	Protein kinase domain-containing protein.	0.634
F6UN86_CIOIN	F6WUP4_CIOIN	ENSCINP00000013966	ENSCINP00000007661	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.589
F6UN86_CIOIN	gla1	ENSCINP00000013966	ENSCINP00000019224	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein LOC780869.	0.914
F6V7C2_CIOIN	Q1RPY5_CIOIN	ENSCINP00000024025	ENSCINP00000030768	Protein kinase domain-containing protein.	Zinc finger protein.	0.756
F6VXC2_CIOIN	F7A9G9_CIOIN	ENSCINP00000015669	ENSCINP00000009356	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RING-type domain-containing protein.	0.513