(126 nodes) Response to lipid network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100184965	Aspartate aminotransferase. (415 aa)
	LOC100178703	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
	F6ZJ88_CIOIN	Uncharacterized protein. (341 aa)
	F6XVY9_CIOIN	HECT domain-containing protein. (862 aa)
	xbpd	Transcription factor protein isoform X1. (366 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	F6VCE5_CIOIN	PALP domain-containing protein. (341 aa)
	LOC100187208	OTU domain-containing protein 5. (592 aa)
	Cibeta-catenin	Uncharacterized protein. (497 aa)
	F6QP05_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein. (291 aa)
	LOC100179624	Histone-lysine N-methyltransferase SMYD3. (430 aa)
	LOC100177066	Uncharacterized protein. (641 aa)
	LOC100176441	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (999 aa)
	F6ZHS2_CIOIN	Uncharacterized protein. (484 aa)
	LOC100183843	Histone H2A; Belongs to the histone H2A family. (128 aa)
	LOC100184540	Death domain-associated protein 6-like isoform X1. (234 aa)
	Xbpa	BZIP domain-containing protein. (309 aa)
	F7B9G3_CIOIN	TGF_BETA_2 domain-containing protein. (387 aa)
	F6R946_CIOIN	Uncharacterized protein. (246 aa)
	F6PRY2_CIOIN	Uncharacterized protein. (655 aa)
	LOC100177411	RuvB-like helicase; Belongs to the RuvB family. (467 aa)
	LOC100186965	Ubiquitin-conjugating enzyme E2 L3-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	F6TFC4_CIOIN	LRRNT domain-containing protein. (542 aa)
	F7B4P8_CIOIN	GTP_cyclohydroI domain-containing protein. (215 aa)
	LOC100179963	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. (363 aa)
	F7BPY2_CIOIN	zf-C2HC5 domain-containing protein. (328 aa)
	F7BQ10_CIOIN	ASCH domain-containing protein. (146 aa)
	F6UHH9_CIOIN	Uncharacterized protein; Belongs to the DEAD box helicase family. (572 aa)
	Ci-FXR	Nuclear receptor. (294 aa)
	F6UYC8_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (396 aa)
	F6Z4V3_CIOIN	Tyrosine-protein kinase. (440 aa)
	Mapkk7	Protein kinase domain-containing protein. (478 aa)
	LOC100183039	Nitric oxide synthase; Produces nitric oxide (NO). (1127 aa)
	Rev-erb	Uncharacterized protein. (597 aa)
	rxr	Nuclear receptor. (507 aa)
	gsk	Glycogen synthase kinase Alpha/beta. (407 aa)
	F7AM41_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (311 aa)
	LOC100181055	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	LOC100178882	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (167 aa)
	F7A0H4_CIOIN	PALP domain-containing protein. (321 aa)
	Tgfbr-iib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)
	F6T336_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	Q69HQ2_CIOIN	Adenylate cyclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (439 aa)
	F6ZGS0_CIOIN	TMF_TATA_bd domain-containing protein. (317 aa)
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	LOC100183684	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (415 aa)
	F6SEF7_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (329 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	F6SXK5_CIOIN	Uncharacterized protein. (504 aa)
	F7BAT7_CIOIN	Prohibitin. (271 aa)
	LOC100187261	Protein FAM210B, mitochondrial isoform X1. (206 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	F6YCG7_CIOIN	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1086 aa)
	LOC100185957	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1. (624 aa)
	LOC100181938	Uncharacterized protein. (452 aa)
	H2Y384_CIOIN	Uncharacterized protein. (77 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
	err	Uncharacterized protein. (515 aa)
	LOC100185829	Uncharacterized protein. (486 aa)
	ENSCINP00000035646	annotation not available (78 aa)
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	Vdr-b	NR LBD domain-containing protein. (128 aa)
	H2XZ67_CIOIN	RWD domain-containing protein. (229 aa)
	H2XXZ2_CIOIN	XRN1_D2_D3 domain-containing protein. (149 aa)
	H2XW59_CIOIN	Uncharacterized protein. (197 aa)
	H2XVX2_CIOIN	BPI1 domain-containing protein. (219 aa)
	H2XUQ8_CIOIN	Uncharacterized protein. (225 aa)
	H2XUK8_CIOIN	BPI1 domain-containing protein. (164 aa)
	H2XU43_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (401 aa)
	LOC100175802	Peroxiredoxin-like. (235 aa)
	Zf(c2h2)-117	Uncharacterized protein. (1015 aa)
	LOC100176104	Uncharacterized protein. (325 aa)
	H2XRJ3_CIOIN	Protein kinase domain-containing protein. (195 aa)
	LOC100185375	Uncharacterized protein. (448 aa)
	H2XQK9_CIOIN	Uncharacterized protein. (836 aa)
	LOC100178035	Sulfhydryl oxidase. (156 aa)
	H2XPV6_CIOIN	BPI1 domain-containing protein. (171 aa)
	hox13	Homeobox transcription factor Hox13. (152 aa)
	H2XMX0_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (143 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	Q1RPY5_CIOIN	Zinc finger protein. (579 aa)
	H2XJY9_CIOIN	Uncharacterized protein. (192 aa)
	LOC100183075	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	F6T1G9_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (316 aa)
	LOC100183426	Membrane progestin receptor beta-like isoform X1. (429 aa)
	F7BG20_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (321 aa)
	F6UYT5_CIOIN	AC_N domain-containing protein. (314 aa)
	Zf(c3h)	Uncharacterized protein. (380 aa)
	ap4	Transcription factor protein isoform X1. (684 aa)
	F6TZA7_CIOIN	Uncharacterized protein. (273 aa)
	LOC100183082	Lipopolysaccharide-binding protein isoform X2. (376 aa)
	LOC100185445	Lipopolysaccharide-binding protein-like. (473 aa)
	F6RIL1_CIOIN	Uncharacterized protein. (179 aa)
	soxh	HMG box domain-containing protein. (752 aa)
	Xbpc	BZIP domain-containing protein. (437 aa)
	F6V5K2_CIOIN	Uncharacterized protein. (467 aa)
	ppar	Nuclear receptor. (644 aa)
	F6V7C2_CIOIN	Protein kinase domain-containing protein. (521 aa)
	F7A912_CIOIN	Uncharacterized protein; Belongs to the peptidase C19 family. (1072 aa)
	LOC100186893	UMP-CMP kinase 2, mitochondrial-like. (420 aa)
	F7AV79_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (228 aa)
	F6UTV8_CIOIN	PALP domain-containing protein. (332 aa)
	ror	Uncharacterized protein. (802 aa)
	LOC100175469	3 beta-hydroxysteroid dehydrogenase type 7-like isoform X1; Belongs to the 3-beta-HSD family. (368 aa)
	F6TX70_CIOIN	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (358 aa)
	F7AQ56_CIOIN	Uncharacterized protein. (229 aa)
	F6TJR3_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (242 aa)
	F6TL19_CIOIN	ENDO3c domain-containing protein. (364 aa)
	xbpb	Transcription factor protein. (238 aa)
	LOC100182077	TNFAIP3-interacting protein 1 isoform X2. (729 aa)
	F6WXG6_CIOIN	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	LOC100187183	Uncharacterized protein. (152 aa)
	F6S3G5_CIOIN	PlsC domain-containing protein. (586 aa)
	LOC100175816	TPR_REGION domain-containing protein. (1034 aa)
	F6PKW3_CIOIN	Tyrosine-protein kinase. (838 aa)
	LOC100175966	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (438 aa)
	LOC100185844	Hydrolase_4 domain-containing protein. (396 aa)
	F6R3M6_CIOIN	Uncharacterized protein. (741 aa)
	LOC104265829	DEAD-box ATP-dependent RNA helicase 20-like; Belongs to the DEAD box helicase family. (573 aa)
	F7AHP3_CIOIN	Uncharacterized protein. (2812 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	LOC100183284	SKIP_SNW domain-containing protein. (534 aa)
	F7A1R5_CIOIN	Uncharacterized protein. (750 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ci-FXR	H2Y0R6_CIOIN	ENSCINP00000007492	ENSCINP00000035500	Nuclear receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.623
Ci-FXR	H2Y2G5_CIOIN	ENSCINP00000007492	ENSCINP00000036100	Nuclear receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.623
Ci-FXR	rxr	ENSCINP00000007492	ENSCINP00000003701	Nuclear receptor.	Nuclear receptor.	0.943
Cibeta-catenin	F6TZA7_CIOIN	ENSCINP00000014417	ENSCINP00000025972	Uncharacterized protein.	Uncharacterized protein.	0.963
Cibeta-catenin	F6Z4V3_CIOIN	ENSCINP00000014417	ENSCINP00000006691	Uncharacterized protein.	Tyrosine-protein kinase.	0.602
Cibeta-catenin	LOC100177411	ENSCINP00000014417	ENSCINP00000009659	Uncharacterized protein.	RuvB-like helicase; Belongs to the RuvB family.	0.696
Cibeta-catenin	LOC100177697	ENSCINP00000014417	ENSCINP00000002782	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.521
Cibeta-catenin	LOC100183075	ENSCINP00000014417	ENSCINP00000029937	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.423
Cibeta-catenin	Smoothened	ENSCINP00000014417	ENSCINP00000002708	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.506
Cibeta-catenin	gsk	ENSCINP00000014417	ENSCINP00000003673	Uncharacterized protein.	Glycogen synthase kinase Alpha/beta.	0.993
Cibeta-catenin	soxh	ENSCINP00000014417	ENSCINP00000024694	Uncharacterized protein.	HMG box domain-containing protein.	0.461
F6PRY2_CIOIN	LOC100183284	ENSCINP00000009819	ENSCINP00000017139	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.500
F6PRY2_CIOIN	LOC100185829	ENSCINP00000009819	ENSCINP00000035652	Uncharacterized protein.	Uncharacterized protein.	0.814
F6R946_CIOIN	LOC100181938	ENSCINP00000009979	ENSCINP00000036408	Uncharacterized protein.	Uncharacterized protein.	0.400
F6RJ65_CIOIN	F6Z4V3_CIOIN	ENSCINP00000001490	ENSCINP00000006691	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein kinase.	0.729
F6RJ65_CIOIN	H2Y2T2_CIOIN	ENSCINP00000001490	ENSCINP00000036217	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.949
F6RJ65_CIOIN	zf(c2h2)-102	ENSCINP00000001490	ENSCINP00000009339	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase.	0.768
F6SEF7_CIOIN	Smoothened	ENSCINP00000000739	ENSCINP00000002708	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.425
F6SXK5_CIOIN	H2XQK9_CIOIN	ENSCINP00000002604	ENSCINP00000031943	Uncharacterized protein.	Uncharacterized protein.	0.672
F6SXK5_CIOIN	H2XXZ2_CIOIN	ENSCINP00000002604	ENSCINP00000034526	Uncharacterized protein.	XRN1_D2_D3 domain-containing protein.	0.519