(91 nodes) Protein localization to nucleus network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100182407	Protein SEC13 homolog; Belongs to the WD repeat SEC13 family. (312 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
	H2Y1J5_CIOIN	Uncharacterized protein. (448 aa)
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	H2Y0I3_CIOIN	G_PROTEIN_RECEP_F2_4 domain-containing protein. (153 aa)
	H2XYB4_CIOIN	Nucleoporin_C domain-containing protein. (1164 aa)
	LOC100184548	NTF2-related export protein-like. (139 aa)
	LOC100180720	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (276 aa)
	LOC100175581	Uncharacterized protein LOC100175581. (186 aa)
	LOC100184449	PIN2/TERF1-interacting telomerase inhibitor 1-like. (260 aa)
	H2XRY8_CIOIN	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (404 aa)
	H2XRV2_CIOIN	Uncharacterized protein. (218 aa)
	LOC100178355	ADP-ribosylation factor-like protein 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	H2XQB7_CIOIN	PHD-type domain-containing protein. (164 aa)
	H2XPB4_CIOIN	Importin subunit alpha; Belongs to the importin alpha family. (527 aa)
	H2XP55_CIOIN	Uncharacterized protein. (682 aa)
	H2XN19_CIOIN	ARL2_Bind_BART domain-containing protein. (156 aa)
	H2XM76_CIOIN	Uncharacterized protein. (1422 aa)
	H2XM12_CIOIN	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (236 aa)
	H2XLI1_CIOIN	Uncharacterized protein. (334 aa)
	H2XKT7_CIOIN	Importin N-terminal domain-containing protein. (144 aa)
	LOC100184417	Exportin-1. (1071 aa)
	LOC100180326	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	F6T2G1_CIOIN	Uncharacterized protein. (298 aa)
	F7A1B7_CIOIN	Uncharacterized protein. (185 aa)
	LOC100176004	PH domain-containing protein. (214 aa)
	F6PNC3_CIOIN	Uncharacterized protein. (1086 aa)
	F6W3W9_CIOIN	Uncharacterized protein. (758 aa)
	F6ZIK8_CIOIN	Uncharacterized protein. (184 aa)
	LOC100182604	Nucleolar protein 8-like. (394 aa)
	F6ZWQ3_CIOIN	Uncharacterized protein. (215 aa)
	F6XAS1_CIOIN	Uncharacterized protein. (502 aa)
	F6SRE5_CIOIN	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (220 aa)
	zf(u1like)-11	Matrin-type domain-containing protein. (640 aa)
	LOC100176470	Brix domain-containing protein. (308 aa)
	LOC100184598	Sequestosome-1 isoform X1. (329 aa)
	LOC100183108	Uncharacterized protein. (171 aa)
	F6XC92_CIOIN	Importin N-terminal domain-containing protein. (1110 aa)
	F6UHM2_CIOIN	Uncharacterized protein. (756 aa)
	F6Z326_CIOIN	Uncharacterized protein. (589 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	LOC100185389	Uncharacterized protein. (231 aa)
	F6XJU3_CIOIN	Uncharacterized protein. (1922 aa)
	zf(rbz)-2	Uncharacterized protein. (1304 aa)
	F6WUB5_CIOIN	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (321 aa)
	F6U8I2_CIOIN	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (236 aa)
	LOC100177747	Nuclear pore protein. (828 aa)
	F6WBK6_CIOIN	TPR_REGION domain-containing protein. (446 aa)
	F7A5V7_CIOIN	WD_REPEATS_REGION domain-containing protein. (501 aa)
	F6PK54_CIOIN	Uncharacterized protein. (331 aa)
	LOC100182844	Importin subunit alpha; Belongs to the importin alpha family. (529 aa)
	LOC100184003	Importin subunit alpha; Belongs to the importin alpha family. (519 aa)
	F6ZF56_CIOIN	Uncharacterized protein. (521 aa)
	F7AGW4_CIOIN	Importin N-terminal domain-containing protein. (1021 aa)
	LOC100175483	Importin N-terminal domain-containing protein. (1067 aa)
	F6TRN8_CIOIN	Uncharacterized protein. (1235 aa)
	LOC100181475	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (300 aa)
	F6THX7_CIOIN	Nsp1_C domain-containing protein. (511 aa)
	F6ZAD3_CIOIN	Rap-GAP domain-containing protein. (1434 aa)
	L7N0T0_CIOIN	RanBD1 domain-containing protein. (120 aa)
	LOC100181289	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	LOC100187200	Importin-11-like. (950 aa)
	F6RS66_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (462 aa)
	LOC100181332	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (814 aa)
	F7B5A5_CIOIN	Importin N-terminal domain-containing protein. (1011 aa)
	LOC100181882	Importin N-terminal domain-containing protein. (922 aa)
	LOC100187055	SEFIR domain-containing protein. (513 aa)
	F6R982_CIOIN	WD_REPEATS_REGION domain-containing protein. (433 aa)
	LOC100178100	Protein Hikeshi. (212 aa)
	F6RMU1_CIOIN	Importin N-terminal domain-containing protein. (883 aa)
	F6ZKW1_CIOIN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (161 aa)
	F6U6V9_CIOIN	Uncharacterized protein. (388 aa)
	F6TLB6_CIOIN	Uncharacterized protein. (891 aa)
	F7A6B8_CIOIN	Uncharacterized protein. (523 aa)
	LOC100177507	60S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
	F6QIV0_CIOIN	DNA_pol_E_B domain-containing protein. (328 aa)
	F6UE50_CIOIN	BTP domain-containing protein. (671 aa)
	F6YDH8_CIOIN	RanBD1 domain-containing protein. (446 aa)
	LOC100179894	Werner syndrome ATP-dependent helicase homolog isoform X1. (1194 aa)
	LOC100179977	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (324 aa)
	LOC100181877	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (307 aa)
	LOC100183609	Importin N-terminal domain-containing protein. (951 aa)
	LOC100177564	Uncharacterized protein. (181 aa)
	LOC100179498	DNA repair protein complementing XP-A cells homolog. (279 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	F6W9U8_CIOIN	PB1 domain-containing protein. (224 aa)
	LOC100182325	Inhibitor of growth protein. (344 aa)
	F6WB99_CIOIN	Uncharacterized protein. (401 aa)
	LOC100176656	lamin-L(II)-like isoform X1; Belongs to the intermediate filament family. (465 aa)
	F6Q753_CIOIN	Uncharacterized protein. (486 aa)
	LOC100180323	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (317 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PK54_CIOIN	F6PNC3_CIOIN	ENSCINP00000018260	ENSCINP00000028708	Uncharacterized protein.	Uncharacterized protein.	0.453
F6PK54_CIOIN	F6Q753_CIOIN	ENSCINP00000018260	ENSCINP00000001028	Uncharacterized protein.	Uncharacterized protein.	0.774
F6PK54_CIOIN	F6RMU1_CIOIN	ENSCINP00000018260	ENSCINP00000009625	Uncharacterized protein.	Importin N-terminal domain-containing protein.	0.738
F6PK54_CIOIN	F6SRE5_CIOIN	ENSCINP00000018260	ENSCINP00000025665	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.815
F6PK54_CIOIN	F6THX7_CIOIN	ENSCINP00000018260	ENSCINP00000014905	Uncharacterized protein.	Nsp1_C domain-containing protein.	0.649
F6PK54_CIOIN	F6TRN8_CIOIN	ENSCINP00000018260	ENSCINP00000017244	Uncharacterized protein.	Uncharacterized protein.	0.797
F6PK54_CIOIN	F6U6V9_CIOIN	ENSCINP00000018260	ENSCINP00000007717	Uncharacterized protein.	Uncharacterized protein.	0.538
F6PK54_CIOIN	F6U8I2_CIOIN	ENSCINP00000018260	ENSCINP00000019434	Uncharacterized protein.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.595
F6PK54_CIOIN	F6WB99_CIOIN	ENSCINP00000018260	ENSCINP00000002206	Uncharacterized protein.	Uncharacterized protein.	0.453
F6PK54_CIOIN	F6WUB5_CIOIN	ENSCINP00000018260	ENSCINP00000019641	Uncharacterized protein.	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.	0.686
F6PK54_CIOIN	F6XAS1_CIOIN	ENSCINP00000018260	ENSCINP00000025868	Uncharacterized protein.	Uncharacterized protein.	0.538
F6PK54_CIOIN	F6YDH8_CIOIN	ENSCINP00000018260	ENSCINP00000005412	Uncharacterized protein.	RanBD1 domain-containing protein.	0.699
F6PK54_CIOIN	F6ZF56_CIOIN	ENSCINP00000018260	ENSCINP00000017696	Uncharacterized protein.	Uncharacterized protein.	0.611
F6PK54_CIOIN	F6ZIK8_CIOIN	ENSCINP00000018260	ENSCINP00000027831	Uncharacterized protein.	Uncharacterized protein.	0.775
F6PK54_CIOIN	F6ZKW1_CIOIN	ENSCINP00000018260	ENSCINP00000008166	Uncharacterized protein.	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.	0.872
F6PK54_CIOIN	F7A6B8_CIOIN	ENSCINP00000018260	ENSCINP00000006931	Uncharacterized protein.	Uncharacterized protein.	0.550
F6PK54_CIOIN	H2XM12_CIOIN	ENSCINP00000018260	ENSCINP00000030694	Uncharacterized protein.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.595
F6PK54_CIOIN	H2XM76_CIOIN	ENSCINP00000018260	ENSCINP00000030758	Uncharacterized protein.	Uncharacterized protein.	0.741
F6PK54_CIOIN	H2XRV2_CIOIN	ENSCINP00000018260	ENSCINP00000032386	Uncharacterized protein.	Uncharacterized protein.	0.550
F6PK54_CIOIN	H2XYB4_CIOIN	ENSCINP00000018260	ENSCINP00000034648	Uncharacterized protein.	Nucleoporin_C domain-containing protein.	0.813