(20 nodes) Multicellular organismal signaling network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6VK85_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (754 aa)
	F6QCF9_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2069 aa)
	LOC100175810	Uncharacterized protein. (633 aa)
	LOC100178767	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (587 aa)
	kcnq1	Uncharacterized protein; Belongs to the potassium channel family. (520 aa)
	F7AUQ0_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1816 aa)
	LOC100176674	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (278 aa)
	LOC100176657	Claudin-1. (232 aa)
	F6TRN8_CIOIN	Uncharacterized protein. (1235 aa)
	LOC100181290	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (390 aa)
	H2XM17_CIOIN	FAT domain-containing protein. (187 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	H2XNH4_CIOIN	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	LOC100177737	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (161 aa)
	H2XWT8_CIOIN	Uncharacterized protein. (206 aa)
	H2XZT3_CIOIN	Uncharacterized protein. (121 aa)
	H2Y066_CIOIN	Uncharacterized protein. (361 aa)
	H2Y0D6_CIOIN	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (282 aa)
	H2Y2S0_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1873 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QCF9_CIOIN	F7AUQ0_CIOIN	ENSCINP00000004967	ENSCINP00000011383	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.566
F6QCF9_CIOIN	H2Y2S0_CIOIN	ENSCINP00000004967	ENSCINP00000036205	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.580
F6VK85_CIOIN	H2XM17_CIOIN	ENSCINP00000002868	ENSCINP00000030699	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.943
F6VK85_CIOIN	H2XWT8_CIOIN	ENSCINP00000002868	ENSCINP00000034122	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.925
F6VK85_CIOIN	H2Y066_CIOIN	ENSCINP00000002868	ENSCINP00000035300	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.929
F7AUQ0_CIOIN	F6QCF9_CIOIN	ENSCINP00000011383	ENSCINP00000004967	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.566
F7AUQ0_CIOIN	H2Y2S0_CIOIN	ENSCINP00000011383	ENSCINP00000036205	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.579
H2XM17_CIOIN	F6VK85_CIOIN	ENSCINP00000030699	ENSCINP00000002868	FAT domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.943
H2XM17_CIOIN	H2XWT8_CIOIN	ENSCINP00000030699	ENSCINP00000034122	FAT domain-containing protein.	Uncharacterized protein.	0.920
H2XM17_CIOIN	H2Y066_CIOIN	ENSCINP00000030699	ENSCINP00000035300	FAT domain-containing protein.	Uncharacterized protein.	0.964
H2XNH4_CIOIN	H2Y0D6_CIOIN	ENSCINP00000031207	ENSCINP00000035370	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.537
H2XNH4_CIOIN	LOC100181290	ENSCINP00000031207	ENSCINP00000024973	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.537
H2XWT8_CIOIN	F6VK85_CIOIN	ENSCINP00000034122	ENSCINP00000002868	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.925
H2XWT8_CIOIN	H2XM17_CIOIN	ENSCINP00000034122	ENSCINP00000030699	Uncharacterized protein.	FAT domain-containing protein.	0.920
H2XWT8_CIOIN	H2Y066_CIOIN	ENSCINP00000034122	ENSCINP00000035300	Uncharacterized protein.	Uncharacterized protein.	0.949
H2Y066_CIOIN	F6VK85_CIOIN	ENSCINP00000035300	ENSCINP00000002868	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.929
H2Y066_CIOIN	H2XM17_CIOIN	ENSCINP00000035300	ENSCINP00000030699	Uncharacterized protein.	FAT domain-containing protein.	0.964
H2Y066_CIOIN	H2XWT8_CIOIN	ENSCINP00000035300	ENSCINP00000034122	Uncharacterized protein.	Uncharacterized protein.	0.949
H2Y0D6_CIOIN	H2XNH4_CIOIN	ENSCINP00000035370	ENSCINP00000031207	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.537
H2Y0D6_CIOIN	LOC100176657	ENSCINP00000035370	ENSCINP00000013053	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Claudin-1.	0.536