(60 nodes) Lipoprotein metabolic process network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100178746	Uncharacterized protein. (429 aa)
	F6ZY26_CIOIN	Uncharacterized protein. (318 aa)
	zf(dhhc)-8	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (380 aa)
	F7BHB8_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (257 aa)
	H2XMD0_CIOIN	Uncharacterized protein. (128 aa)
	H2XJI2_CIOIN	Uncharacterized protein. (98 aa)
	F6WBQ8_CIOIN	Metallophos domain-containing protein. (211 aa)
	F6ZYZ4_CIOIN	Uncharacterized protein. (230 aa)
	H2XQ42_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (266 aa)
	LOC100177849	Golgin subfamily A member 7. (132 aa)
	selk	Uncharacterized protein. (89 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (268 aa)
	H2XVJ7_CIOIN	Uncharacterized protein. (507 aa)
	H2XX93_CIOIN	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (468 aa)
	H2XYG9_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (148 aa)
	H2Y0A4_CIOIN	Uncharacterized protein. (159 aa)
	LOC101242365	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (98 aa)
	LOC100177059	PigN domain-containing protein. (919 aa)
	H2XMX2_CIOIN	Uncharacterized protein. (513 aa)
	H2XP51_CIOIN	Uncharacterized protein. (980 aa)
	LOC100181401	WD repeat domain phosphoinositide-interacting protein 4. (344 aa)
	H2Y274_CIOIN	Uncharacterized protein. (532 aa)
	zf(dhhc)-2	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (561 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	LOC100179414	Phosphatidylinositol glycan anchor biosynthesis class U protein. (431 aa)
	F6ZRT4_CIOIN	Uncharacterized protein. (1001 aa)
	LOC100180163	post-GPI attachment to proteins factor 2-like. (256 aa)
	F6RR57_CIOIN	Mannosyltransferase. (442 aa)
	LOC100175499	WD_REPEATS_REGION domain-containing protein. (610 aa)
	F6X6G2_CIOIN	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (221 aa)
	F6X8F0_CIOIN	RGS domain-containing protein. (394 aa)
	F6YSQ6_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (315 aa)
	F6PH01_CIOIN	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (257 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	F6YLE1_CIOIN	GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (919 aa)
	zf(dhhc)-4	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (590 aa)
	F6XQV0_CIOIN	Vitellogenin domain-containing protein. (896 aa)
	LOC100178837	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (217 aa)
	LOC100180591	Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (241 aa)
	F6XPI8_CIOIN	Abhydrolase_2 domain-containing protein. (92 aa)
	F6S3H3_CIOIN	Hydrolase_4 domain-containing protein. (243 aa)
	H2XJF2_CIOIN	Phosphatidylinositol 3-kinase catalytic subunit type 3. (931 aa)
	F6YG27_CIOIN	Uncharacterized protein. (446 aa)
	F6YFR8_CIOIN	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (275 aa)
	F6ZQH5_CIOIN	Uncharacterized protein. (250 aa)
	F6TZ29_CIOIN	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (678 aa)
	F6SPI0_CIOIN	ANK_REP_REGION domain-containing protein. (264 aa)
	F6VUM2_CIOIN	Glutamine synthetase. (334 aa)
	zf(dhhc)-1	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (355 aa)
	F6YVU0_CIOIN	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (371 aa)
	LOC100175389	Uncharacterized protein. (350 aa)
	F6UMH6_CIOIN	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (377 aa)
	LOC100180902	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (283 aa)
	F6S8C9_CIOIN	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (122 aa)
	F7A2R6_CIOIN	Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (501 aa)
	LOC100177362	Palmitoyl-protein thioesterase 1. (292 aa)
	LOC100183363	Protein phosphatase 1A-like isoform X2. (412 aa)
	LOC100180836	WD repeat domain phosphoinositide-interacting protein 3. (336 aa)
	F7A1T4_CIOIN	Uncharacterized protein. (401 aa)
	F6YD02_CIOIN	Hydrolase_4 domain-containing protein. (288 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6RJ65_CIOIN	H2Y2T2_CIOIN	ENSCINP00000001490	ENSCINP00000036217	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.949
F6RR57_CIOIN	F6S8C9_CIOIN	ENSCINP00000025105	ENSCINP00000014961	Mannosyltransferase.	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	0.642
F6RR57_CIOIN	F6X6G2_CIOIN	ENSCINP00000025105	ENSCINP00000022793	Mannosyltransferase.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.646
F6RR57_CIOIN	F6X8F0_CIOIN	ENSCINP00000025105	ENSCINP00000022227	Mannosyltransferase.	RGS domain-containing protein.	0.645
F6RR57_CIOIN	F6ZQH5_CIOIN	ENSCINP00000025105	ENSCINP00000009396	Mannosyltransferase.	Uncharacterized protein.	0.475
F6RR57_CIOIN	F6ZRT4_CIOIN	ENSCINP00000025105	ENSCINP00000028216	Mannosyltransferase.	Uncharacterized protein.	0.642
F6RR57_CIOIN	F7A1T4_CIOIN	ENSCINP00000025105	ENSCINP00000017071	Mannosyltransferase.	Uncharacterized protein.	0.459
F6RR57_CIOIN	F7A2R6_CIOIN	ENSCINP00000025105	ENSCINP00000015815	Mannosyltransferase.	Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.	0.493
F6RR57_CIOIN	H2XMX2_CIOIN	ENSCINP00000025105	ENSCINP00000031005	Mannosyltransferase.	Uncharacterized protein.	0.484
F6RR57_CIOIN	H2XP51_CIOIN	ENSCINP00000025105	ENSCINP00000031434	Mannosyltransferase.	Uncharacterized protein.	0.535
F6RR57_CIOIN	LOC100175389	ENSCINP00000025105	ENSCINP00000013500	Mannosyltransferase.	Uncharacterized protein.	0.510
F6RR57_CIOIN	LOC100177059	ENSCINP00000025105	ENSCINP00000035708	Mannosyltransferase.	PigN domain-containing protein.	0.589
F6S8C9_CIOIN	F6RR57_CIOIN	ENSCINP00000014961	ENSCINP00000025105	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Mannosyltransferase.	0.642
F6S8C9_CIOIN	F6X6G2_CIOIN	ENSCINP00000014961	ENSCINP00000022793	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.644
F6S8C9_CIOIN	F6X8F0_CIOIN	ENSCINP00000014961	ENSCINP00000022227	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	RGS domain-containing protein.	0.642
F6S8C9_CIOIN	F6YFR8_CIOIN	ENSCINP00000014961	ENSCINP00000008799	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.	0.526
F6S8C9_CIOIN	F6YLE1_CIOIN	ENSCINP00000014961	ENSCINP00000001839	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.	0.648
F6S8C9_CIOIN	F6ZQH5_CIOIN	ENSCINP00000014961	ENSCINP00000009396	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Uncharacterized protein.	0.642
F6S8C9_CIOIN	F6ZRT4_CIOIN	ENSCINP00000014961	ENSCINP00000028216	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Uncharacterized protein.	0.663
F6S8C9_CIOIN	F7A2R6_CIOIN	ENSCINP00000014961	ENSCINP00000015815	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.	0.474