(119 nodes) Regulation of protein catabolic process network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100177439	Serine/threonine/tyrosine-interacting protein-like. (218 aa)
	H2XN10_CIOIN	Uncharacterized protein. (271 aa)
	H2XRK6_CIOIN	HORMA domain-containing protein. (87 aa)
	H2XRS0_CIOIN	TPR_REGION domain-containing protein. (201 aa)
	ekn1	EKN1 protein. (434 aa)
	H2XRY8_CIOIN	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (404 aa)
	LOC100182606	Uncharacterized protein. (568 aa)
	H2XUX2_CIOIN	Uncharacterized protein. (213 aa)
	H2XVG9_CIOIN	Rab-GAP TBC domain-containing protein. (228 aa)
	H2XVP2_CIOIN	Uncharacterized protein. (226 aa)
	H2XXK6_CIOIN	Uncharacterized protein. (518 aa)
	H2XXX0_CIOIN	RBR-type E3 ubiquitin transferase. (216 aa)
	H2XY37_CIOIN	Uncharacterized protein. (127 aa)
	H2XY58_CIOIN	PHR domain-containing protein. (416 aa)
	H2XY93_CIOIN	Protein kinase domain-containing protein. (105 aa)
	LOC100180100	Uncharacterized protein. (204 aa)
	LOC100186168	Ras-related protein Rab-26-like. (223 aa)
	H2Y0K6_CIOIN	Uncharacterized protein. (3252 aa)
	H2Y1J2_CIOIN	Uncharacterized protein. (499 aa)
	H2Y2K4_CIOIN	3-hydroxy-3-methylglutaryl coenzyme A reductase. (807 aa)
	H2Y3R6_CIOIN	Uncharacterized protein. (156 aa)
	H2Y3S9_CIOIN	RPN2_C domain-containing protein. (79 aa)
	F6SYB9_CIOIN	DUF862 domain-containing protein. (141 aa)
	F6Y9R7_CIOIN	Uncharacterized protein. (556 aa)
	F6TDQ4_CIOIN	Ubiquitin-like domain-containing protein. (251 aa)
	F6V0W8_CIOIN	Uncharacterized protein. (235 aa)
	LOC100175152	Bis(5'-adenosyl)-triphosphatase. (154 aa)
	F6V4V0_CIOIN	Sortilin. (1459 aa)
	F6YFA0_CIOIN	Uncharacterized protein. (62 aa)
	F6YFA6_CIOIN	APC_N_CC domain-containing protein. (151 aa)
	F6YFI1_CIOIN	Uncharacterized protein. (132 aa)
	LOC100179846	Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (344 aa)
	F7A912_CIOIN	Uncharacterized protein; Belongs to the peptidase C19 family. (1072 aa)
	LOC100176678	PITH domain-containing protein 1. (209 aa)
	LOC100184038	Ornithine decarboxylase antizyme. (173 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	LOC100182534	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (208 aa)
	F6PIV0_CIOIN	TPR_REGION domain-containing protein. (290 aa)
	LOC100186863	PDZ domain-containing protein GIPC1. (316 aa)
	LOC100187162	AAA domain-containing protein; Belongs to the AAA ATPase family. (393 aa)
	Q1RL49_CIOIN	RBR-type E3 ubiquitin transferase. (455 aa)
	F7B3P4_CIOIN	Uncharacterized protein. (325 aa)
	F6Z6J9_CIOIN	NTR domain-containing protein. (193 aa)
	LOC100185231	RAB6A-GEF complex partner protein 2. (386 aa)
	F6W510_CIOIN	Uncharacterized protein. (704 aa)
	F6W673_CIOIN	RBR-type E3 ubiquitin transferase. (502 aa)
	F6WSZ7_CIOIN	Uncharacterized protein. (591 aa)
	F6XWE7_CIOIN	Serine/threonine-protein kinase PLK. (754 aa)
	F7ANR5_CIOIN	CPSF_A domain-containing protein. (1145 aa)
	F7ANZ8_CIOIN	Uncharacterized protein. (293 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	LOC100181381	UBX domain-containing protein. (367 aa)
	LOC100187157	Uncharacterized protein; Belongs to the AAA ATPase family. (811 aa)
	Zf(ubp)-1	Ubiquitin carboxyl-terminal hydrolase. (825 aa)
	F6WAC8_CIOIN	CDC48_N domain-containing protein. (222 aa)
	F6WAD4_CIOIN	AAA domain-containing protein; Belongs to the AAA ATPase family. (461 aa)
	F7AZS8_CIOIN	Uncharacterized protein. (199 aa)
	LOC100181206	TPR_REGION domain-containing protein. (1027 aa)
	LOC100183552	ANK_REP_REGION domain-containing protein. (230 aa)
	F7B1X4_CIOIN	WD_REPEATS_REGION domain-containing protein. (523 aa)
	zf(ring)-30	Zinc finger protein. (645 aa)
	F7BLS5_CIOIN	PCI domain-containing protein. (398 aa)
	F6ZGX7_CIOIN	Uncharacterized protein. (629 aa)
	F6ZGZ0_CIOIN	Uncharacterized protein. (615 aa)
	LOC100185251-2	Zinc finger protein. (339 aa)
	LOC100185096	26S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
	F6Z1D9_CIOIN	PA28_beta domain-containing protein. (255 aa)
	F6UW73_CIOIN	Uncharacterized protein. (301 aa)
	F6Z7S0_CIOIN	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (334 aa)
	F6WMB2_CIOIN	Uncharacterized protein. (524 aa)
	LOC100176903	Carboxypeptidase; Belongs to the peptidase S10 family. (420 aa)
	H2XJH2_CIOIN	Uncharacterized protein. (216 aa)
	LOC100187458	Small VCP/p97-interacting protein. (76 aa)
	LOC100177760	FAS-associated factor 1-like. (168 aa)
	LOC100184417	Exportin-1. (1071 aa)
	F6TTI3_CIOIN	Ubiquitin carboxyl-terminal hydrolase. (512 aa)
	F6YGJ7_CIOIN	Uncharacterized protein; Belongs to the peptidase C19 family. (1099 aa)
	F7B5N7_CIOIN	Protein kinase domain-containing protein. (353 aa)
	F6UI66_CIOIN	Uncharacterized protein. (316 aa)
	F6YHN3_CIOIN	Uncharacterized protein. (728 aa)
	LOC100184190	AAA domain-containing protein; Belongs to the AAA ATPase family. (419 aa)
	F6XH38_CIOIN	Uncharacterized protein. (637 aa)
	F6TJJ7_CIOIN	Uncharacterized protein. (466 aa)
	F6UXR3_CIOIN	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (901 aa)
	F6YT91_CIOIN	Uncharacterized protein. (800 aa)
	LOC100182082	AAA domain-containing protein; Belongs to the AAA ATPase family. (463 aa)
	F7BHP4_CIOIN	AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
	F6U9S1_CIOIN	RING-type domain-containing protein. (911 aa)
	F6XKP0_CIOIN	AAA domain-containing protein; Belongs to the AAA ATPase family. (397 aa)
	LOC100177507	60S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
	F6Z5N9_CIOIN	Rhomboid domain-containing protein. (213 aa)
	F6S376_CIOIN	PA28_alpha domain-containing protein. (82 aa)
	F6SPV5_CIOIN	RBR-type E3 ubiquitin transferase. (401 aa)
	LOC100175171	RING finger and CHY zinc finger domain-containing protein 1. (278 aa)
	F6SDI7_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (435 aa)
	LOC100181871	t-SNARE coiled-coil homology domain-containing protein. (310 aa)
	Axin	Uncharacterized protein. (643 aa)
	LOC100176571	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (198 aa)
	LOC100176145	Sorting nexin-12-like isoform X1. (165 aa)
	gsk	Glycogen synthase kinase Alpha/beta. (407 aa)
	F7AMQ2_CIOIN	TPR_REGION domain-containing protein. (186 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	LOC100178056	Splicing factor 3B subunit 3 isoform X1. (1216 aa)
	Sir2-d	Deacetylase sirtuin-type domain-containing protein. (91 aa)
	F7B0L4_CIOIN	Uncharacterized protein. (344 aa)
	F6UNP2_CIOIN	WD_REPEATS_REGION domain-containing protein. (464 aa)
	F7BAT7_CIOIN	Prohibitin. (271 aa)
	LOC100175935	Ubiquitin carboxyl-terminal hydrolase. (328 aa)
	H2XL89_CIOIN	PHR domain-containing protein. (208 aa)
	LOC100179683	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	H2XM49_CIOIN	PX domain-containing protein. (112 aa)
	LOC104265547	Uncharacterized protein LOC104265547 isoform X1. (119 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	F6U1K7_CIOIN	RBR-type E3 ubiquitin transferase. (510 aa)
	LOC100182102	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (439 aa)
	F6VS42_CIOIN	Uncharacterized protein. (494 aa)
	F6VSL5_CIOIN	RIC1 domain-containing protein. (364 aa)
	F6ZGS0_CIOIN	TMF_TATA_bd domain-containing protein. (317 aa)
	LOC100180632	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (804 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Axin	F6SDI7_CIOIN	ENSCINP00000005332	ENSCINP00000005898	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.690
Axin	F6YFA0_CIOIN	ENSCINP00000005332	ENSCINP00000024272	Uncharacterized protein.	Uncharacterized protein.	0.907
Axin	F6YFA6_CIOIN	ENSCINP00000005332	ENSCINP00000024271	Uncharacterized protein.	APC_N_CC domain-containing protein.	0.807
Axin	F7AZS8_CIOIN	ENSCINP00000005332	ENSCINP00000014027	Uncharacterized protein.	Uncharacterized protein.	0.907
Axin	LOC100179683	ENSCINP00000005332	ENSCINP00000030575	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 14.	0.401
Axin	gsk	ENSCINP00000005332	ENSCINP00000003673	Uncharacterized protein.	Glycogen synthase kinase Alpha/beta.	0.999
F6PIV0_CIOIN	F6YHN3_CIOIN	ENSCINP00000020208	ENSCINP00000008442	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.509
F6PIV0_CIOIN	H2XRS0_CIOIN	ENSCINP00000020208	ENSCINP00000032354	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.848
F6S376_CIOIN	F6TTI3_CIOIN	ENSCINP00000006551	ENSCINP00000008849	PA28_alpha domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.531
F6S376_CIOIN	F6UXR3_CIOIN	ENSCINP00000006551	ENSCINP00000007427	PA28_alpha domain-containing protein.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.631
F6S376_CIOIN	F6XKP0_CIOIN	ENSCINP00000006551	ENSCINP00000007040	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.667
F6S376_CIOIN	F7BHP4_CIOIN	ENSCINP00000006551	ENSCINP00000007206	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.681
F6S376_CIOIN	F7BLS5_CIOIN	ENSCINP00000006551	ENSCINP00000012483	PA28_alpha domain-containing protein.	PCI domain-containing protein.	0.637
F6S376_CIOIN	H2XJH2_CIOIN	ENSCINP00000006551	ENSCINP00000029804	PA28_alpha domain-containing protein.	Uncharacterized protein.	0.668
F6S376_CIOIN	H2Y3S9_CIOIN	ENSCINP00000006551	ENSCINP00000036564	PA28_alpha domain-containing protein.	RPN2_C domain-containing protein.	0.430
F6S376_CIOIN	LOC100175935	ENSCINP00000006551	ENSCINP00000001676	PA28_alpha domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.405
F6S376_CIOIN	LOC100179683	ENSCINP00000006551	ENSCINP00000030575	PA28_alpha domain-containing protein.	26S proteasome non-ATPase regulatory subunit 14.	0.775
F6S376_CIOIN	LOC100182082	ENSCINP00000006551	ENSCINP00000007307	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.638
F6S376_CIOIN	LOC100184190	ENSCINP00000006551	ENSCINP00000008054	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.632
F6S376_CIOIN	LOC100185096	ENSCINP00000006551	ENSCINP00000011875	PA28_alpha domain-containing protein.	26S proteasome regulatory subunit 7; Belongs to the AAA ATPase family.	0.631