(46 nodes) Negative regulation of MAPK cascade network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

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Your Input:
	F7BAT7_CIOIN	Prohibitin. (271 aa)
	LOC104265605	Uncharacterized protein. (575 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6YRG2_CIOIN	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (211 aa)
	F6UJF1_CIOIN	UDENN FLCN/SMCR8-type domain-containing protein. (561 aa)
	F6ZYB8_CIOIN	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	atf3	Transcription factor protein isoform X1. (273 aa)
	F6PHM0_CIOIN	Uncharacterized protein. (498 aa)
	LOC100187074	Uncharacterized protein. (549 aa)
	LOC100186563	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family. (599 aa)
	F6TLB6_CIOIN	Uncharacterized protein. (891 aa)
	Zf(c2h2)-88	Uncharacterized protein. (912 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	smad4	Mothers against decapentaplegic homolog. (527 aa)
	Ephrin-a	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (248 aa)
	F6ZG18_CIOIN	FERM domain-containing protein. (589 aa)
	LOC100183552	ANK_REP_REGION domain-containing protein. (230 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	F6TGU6_CIOIN	Uncharacterized protein. (420 aa)
	F7AA01_CIOIN	Glucosylceramidase. (561 aa)
	foxm	Fork-head domain-containing protein. (916 aa)
	F6Q9D5_CIOIN	Metallophos domain-containing protein. (435 aa)
	LOC100185430	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (772 aa)
	Dusp6.9	Uncharacterized protein. (499 aa)
	F6Z402_CIOIN	Peptidase S72 domain-containing protein. (410 aa)
	LOC100182077	TNFAIP3-interacting protein 1 isoform X2. (729 aa)
	F6YQI1_CIOIN	Uncharacterized protein. (245 aa)
	Dusp1.2.4.5	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (434 aa)
	F6WQ64_CIOIN	Aida_C2 domain-containing protein. (192 aa)
	LOC100179846	Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (344 aa)
	F6V4V0_CIOIN	Sortilin. (1459 aa)
	F6ZBN8_CIOIN	CAP-Gly domain-containing protein. (292 aa)
	F7A3S4_CIOIN	Uncharacterized protein. (272 aa)
	LOC100187111	Protein C3orf33 homolog. (262 aa)
	F6W3W9_CIOIN	Uncharacterized protein. (758 aa)
	F6T2G1_CIOIN	Uncharacterized protein. (298 aa)
	H2XJY8_CIOIN	Glucosylceramidase. (518 aa)
	H2XKK1_CIOIN	Uncharacterized protein. (267 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	Bmp2/4	TGFb_propeptide domain-containing protein. (376 aa)
	H2XTY2_CIOIN	Uncharacterized protein. (882 aa)
	H2XXK6_CIOIN	Uncharacterized protein. (518 aa)
	H2XZ02_CIOIN	WH1 domain-containing protein. (414 aa)
	ci-zf(c2h2)-87	Zinc finger protein LOC723797 isoform X1. (1251 aa)
	H2Y1K5_CIOIN	Uncharacterized protein. (469 aa)
	H2Y2K4_CIOIN	3-hydroxy-3-methylglutaryl coenzyme A reductase. (807 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp2/4	smad4	ENSCINP00000031019	ENSCINP00000011529	TGFb_propeptide domain-containing protein.	Mothers against decapentaplegic homolog.	0.906
F6T2G1_CIOIN	F6TLB6_CIOIN	ENSCINP00000029547	ENSCINP00000007196	Uncharacterized protein.	Uncharacterized protein.	0.950
F6T2G1_CIOIN	F6W3W9_CIOIN	ENSCINP00000029547	ENSCINP00000028344	Uncharacterized protein.	Uncharacterized protein.	0.946
F6T2G1_CIOIN	H2XZ02_CIOIN	ENSCINP00000029547	ENSCINP00000034886	Uncharacterized protein.	WH1 domain-containing protein.	0.777
F6TLB6_CIOIN	F6T2G1_CIOIN	ENSCINP00000007196	ENSCINP00000029547	Uncharacterized protein.	Uncharacterized protein.	0.950
F6TLB6_CIOIN	F6W3W9_CIOIN	ENSCINP00000007196	ENSCINP00000028344	Uncharacterized protein.	Uncharacterized protein.	0.949
F6TLB6_CIOIN	H2XZ02_CIOIN	ENSCINP00000007196	ENSCINP00000034886	Uncharacterized protein.	WH1 domain-containing protein.	0.777
F6UJF1_CIOIN	LOC104265605	ENSCINP00000003434	ENSCINP00000002720	UDENN FLCN/SMCR8-type domain-containing protein.	Uncharacterized protein.	0.647
F6W3W9_CIOIN	F6T2G1_CIOIN	ENSCINP00000028344	ENSCINP00000029547	Uncharacterized protein.	Uncharacterized protein.	0.946
F6W3W9_CIOIN	F6TLB6_CIOIN	ENSCINP00000028344	ENSCINP00000007196	Uncharacterized protein.	Uncharacterized protein.	0.949
F6W3W9_CIOIN	H2XZ02_CIOIN	ENSCINP00000028344	ENSCINP00000034886	Uncharacterized protein.	WH1 domain-containing protein.	0.777
F6YRG2_CIOIN	LOC100177697	ENSCINP00000002792	ENSCINP00000002782	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.494
F6YRG2_CIOIN	LOC100178517	ENSCINP00000002792	ENSCINP00000030917	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.491
F6Z402_CIOIN	H2Y1K5_CIOIN	ENSCINP00000018986	ENSCINP00000035789	Peptidase S72 domain-containing protein.	Uncharacterized protein.	0.616
F6ZYB8_CIOIN	F7AA01_CIOIN	ENSCINP00000005699	ENSCINP00000016220	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	Glucosylceramidase.	0.921
F6ZYB8_CIOIN	H2XJY8_CIOIN	ENSCINP00000005699	ENSCINP00000029970	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	Glucosylceramidase.	0.921
F6ZYB8_CIOIN	LOC100186563	ENSCINP00000005699	ENSCINP00000006326	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	0.908
F7AA01_CIOIN	F6ZYB8_CIOIN	ENSCINP00000016220	ENSCINP00000005699	Glucosylceramidase.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	0.921
F7AA01_CIOIN	H2XJY8_CIOIN	ENSCINP00000016220	ENSCINP00000029970	Glucosylceramidase.	Glucosylceramidase.	0.903
F7AA01_CIOIN	LOC100186563	ENSCINP00000016220	ENSCINP00000006326	Glucosylceramidase.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.	0.921