(39 nodes) Mitotic DNA damage checkpoint signaling network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	H2Y1A0_CIOIN	Uncharacterized protein. (345 aa)
	H2XYV9_CIOIN	Uncharacterized protein. (444 aa)
	H2XXS5_CIOIN	Uncharacterized protein. (440 aa)
	H2XXK6_CIOIN	Uncharacterized protein. (518 aa)
	H2XRY8_CIOIN	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (404 aa)
	H2XMH8_CIOIN	BHD_1 domain-containing protein. (362 aa)
	H2XLY1_CIOIN	Uncharacterized protein. (292 aa)
	LOC100184450	Uncharacterized protein. (240 aa)
	F6TZN8_CIOIN	WW domain-containing protein. (437 aa)
	F7BLE6_CIOIN	BHD_3 domain-containing protein. (221 aa)
	F7A9P4_CIOIN	NUC194 domain-containing protein. (726 aa)
	F6R213_CIOIN	Uncharacterized protein. (1264 aa)
	F6PLC9_CIOIN	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (128 aa)
	F6WC79_CIOIN	Uncharacterized protein. (347 aa)
	F6Z8G0_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
	F6ZJN0_CIOIN	Uncharacterized protein. (203 aa)
	F6VN25_CIOIN	Uncharacterized protein. (889 aa)
	F6QSJ0_CIOIN	Uncharacterized protein. (453 aa)
	F6UCG0_CIOIN	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (943 aa)
	LOC100179869	Checkpoint protein; Belongs to the HUS1 family. (286 aa)
	LOC100185652	Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family. (530 aa)
	F6WMB2_CIOIN	Uncharacterized protein. (524 aa)
	LOC100175771	Cell cycle checkpoint control protein; Belongs to the rad9 family. (424 aa)
	F6WPB7_CIOIN	BRCC36_C domain-containing protein. (108 aa)
	F7ATF3_CIOIN	zf-4CXXC_R1 domain-containing protein. (286 aa)
	ENSCINP00000009254	Uncharacterized protein. (173 aa)
	F6XGS0_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	F6UDW5_CIOIN	Protein kinase domain-containing protein. (859 aa)
	F6QHZ5_CIOIN	FHA domain-containing protein. (234 aa)
	F6UM67_CIOIN	RING-type domain-containing protein. (762 aa)
	F6VD75_CIOIN	Uncharacterized protein. (553 aa)
	F6SW20_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (436 aa)
	F6W768_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (390 aa)
	Foxn2/3	Fork-head domain-containing protein. (748 aa)
	F6UNP2_CIOIN	WD_REPEATS_REGION domain-containing protein. (464 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	H2Y3C6_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (540 aa)
	H2Y3M4_CIOIN	Uncharacterized protein. (185 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCINP00000009254	H2XYV9_CIOIN	ENSCINP00000009254	ENSCINP00000034843	Uncharacterized protein.	Uncharacterized protein.	0.952
F6PLC9_CIOIN	F6UM67_CIOIN	ENSCINP00000018210	ENSCINP00000003190	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	RING-type domain-containing protein.	0.494
F6PLC9_CIOIN	F6VD75_CIOIN	ENSCINP00000018210	ENSCINP00000003159	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.414
F6PLC9_CIOIN	F6VN25_CIOIN	ENSCINP00000018210	ENSCINP00000014263	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.819
F6PLC9_CIOIN	F6WC79_CIOIN	ENSCINP00000018210	ENSCINP00000017779	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.738
F6PLC9_CIOIN	F6WMB2_CIOIN	ENSCINP00000018210	ENSCINP00000010261	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Uncharacterized protein.	0.663
F6PLC9_CIOIN	F6Z8G0_CIOIN	ENSCINP00000018210	ENSCINP00000016265	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.732
F6PLC9_CIOIN	F7ATF3_CIOIN	ENSCINP00000018210	ENSCINP00000009323	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	zf-4CXXC_R1 domain-containing protein.	0.551
F6PLC9_CIOIN	LOC100175771	ENSCINP00000018210	ENSCINP00000010009	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.665
F6PLC9_CIOIN	LOC100179869	ENSCINP00000018210	ENSCINP00000011013	TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.	Checkpoint protein; Belongs to the HUS1 family.	0.706
F6QHZ5_CIOIN	F6R213_CIOIN	ENSCINP00000004918	ENSCINP00000018395	FHA domain-containing protein.	Uncharacterized protein.	0.540
F6QHZ5_CIOIN	F6RJ65_CIOIN	ENSCINP00000004918	ENSCINP00000001490	FHA domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.928
F6QHZ5_CIOIN	F6UCG0_CIOIN	ENSCINP00000004918	ENSCINP00000012971	FHA domain-containing protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.457
F6QHZ5_CIOIN	F6VD75_CIOIN	ENSCINP00000004918	ENSCINP00000003159	FHA domain-containing protein.	Uncharacterized protein.	0.682
F6QHZ5_CIOIN	F6WC79_CIOIN	ENSCINP00000004918	ENSCINP00000017779	FHA domain-containing protein.	Uncharacterized protein.	0.781
F6QHZ5_CIOIN	F6WMB2_CIOIN	ENSCINP00000004918	ENSCINP00000010261	FHA domain-containing protein.	Uncharacterized protein.	0.754
F6QHZ5_CIOIN	F6WPB7_CIOIN	ENSCINP00000004918	ENSCINP00000009483	FHA domain-containing protein.	BRCC36_C domain-containing protein.	0.518
F6QHZ5_CIOIN	F6Z8G0_CIOIN	ENSCINP00000004918	ENSCINP00000016265	FHA domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.594
F6QHZ5_CIOIN	F7A9P4_CIOIN	ENSCINP00000004918	ENSCINP00000023638	FHA domain-containing protein.	NUC194 domain-containing protein.	0.562
F6QHZ5_CIOIN	F7ATF3_CIOIN	ENSCINP00000004918	ENSCINP00000009323	FHA domain-containing protein.	zf-4CXXC_R1 domain-containing protein.	0.593