(96 nodes) Positive regulation of cell cycle network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2XSB0_CIOIN	Uncharacterized protein. (578 aa)
	H2XSQ9_CIOIN	MTBP_C domain-containing protein. (144 aa)
	LOC100179293	PPP1R35_C domain-containing protein. (256 aa)
	H2XTM9_CIOIN	ATP-cone domain-containing protein. (31 aa)
	LOC100184078	CDT1 domain-containing protein. (407 aa)
	H2XUU5_CIOIN	Uncharacterized protein. (532 aa)
	H2XUY6_CIOIN	Cullin_Nedd8 domain-containing protein; Belongs to the cullin family. (145 aa)
	H2Y0K6_CIOIN	Uncharacterized protein. (3252 aa)
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	H2Y0Y1_CIOIN	Uncharacterized protein. (227 aa)
	H2Y1I9_CIOIN	Sm domain-containing protein. (115 aa)
	H2Y296_CIOIN	Uncharacterized protein. (234 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
	H2Y2R4_CIOIN	Uncharacterized protein. (167 aa)
	LOC100185658	Kinetochore protein NDC80 homolog. (596 aa)
	F6SW03_CIOIN	Uncharacterized protein. (362 aa)
	F6TI28_CIOIN	Mitogen-activated protein kinase. (364 aa)
	F7AE79_CIOIN	SP-RING-type domain-containing protein. (239 aa)
	LOC100175879	CULLIN_2 domain-containing protein; Belongs to the cullin family. (614 aa)
	F6WB99_CIOIN	Uncharacterized protein. (401 aa)
	cdc42	Uncharacterized protein. (95 aa)
	LOC100176030	WD_REPEATS_REGION domain-containing protein. (1206 aa)
	F6WDZ2_CIOIN	RIBORED_LARGE domain-containing protein. (193 aa)
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	LOC100180482	Structural maintenance of chromosomes protein. (1202 aa)
	LOC100186221	Uncharacterized protein. (269 aa)
	LOC100182084	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (461 aa)
	F6T7Q1_CIOIN	HP domain-containing protein. (640 aa)
	LOC100185308	Sm domain-containing protein. (173 aa)
	F6R472_CIOIN	CULLIN_2 domain-containing protein; Belongs to the cullin family. (707 aa)
	LOC100182930	Centromere protein V-like. (142 aa)
	F6PL57_CIOIN	Uncharacterized protein. (1087 aa)
	F6TBE2_CIOIN	Uncharacterized protein. (444 aa)
	LOC100182936	RING finger protein 212B-like isoform X1. (310 aa)
	F6WYC4_CIOIN	TFIIS N-terminal domain-containing protein. (494 aa)
	LOC100187303	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (824 aa)
	F7ADN1_CIOIN	Structural maintenance of chromosomes protein. (1253 aa)
	F6ZM08_CIOIN	Uncharacterized protein. (782 aa)
	F6WMB2_CIOIN	Uncharacterized protein. (524 aa)
	F6TAK8_CIOIN	Uncharacterized protein. (367 aa)
	LOC100176196	Protein RCC2 homolog. (475 aa)
	F6U3S7_CIOIN	OB_NTP_bind domain-containing protein. (348 aa)
	LOC100176070	Mitotic spindle assembly checkpoint protein MAD1. (714 aa)
	LOC100185251-2	Zinc finger protein. (339 aa)
	LOC100183552	ANK_REP_REGION domain-containing protein. (230 aa)
	F6QSH0_CIOIN	Uncharacterized protein. (709 aa)
	F6RJ81_CIOIN	ANK_REP_REGION domain-containing protein. (400 aa)
	F6YAQ4_CIOIN	Uncharacterized protein. (240 aa)
	LOC100182501	TPR_REGION domain-containing protein. (560 aa)
	F6SAD5_CIOIN	Uncharacterized protein; Belongs to the cyclin family. (514 aa)
	LOC100176493	AAA domain-containing protein. (844 aa)
	F6W785_CIOIN	Uncharacterized protein. (695 aa)
	F6XWY9_CIOIN	TPR_REGION domain-containing protein. (823 aa)
	F6UJI9_CIOIN	Uncharacterized protein. (487 aa)
	F6T7M7_CIOIN	Uncharacterized protein. (492 aa)
	LOC100180438	Polymerase delta-interacting protein 2-like. (376 aa)
	F6THB4_CIOIN	Uncharacterized protein. (181 aa)
	F6Z8G0_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
	F6SSU2_CIOIN	TPR_REGION domain-containing protein. (387 aa)
	LOC100181789	AAA_23 domain-containing protein. (1070 aa)
	zf(ring)-55	Zinc finger protein. (323 aa)
	LOC100182716	Flap endonuclease GEN homolog 1. (709 aa)
	tbx2/3	T-box containing transcription factor isoform X2. (803 aa)
	F6WCV2_CIOIN	Protein kinase domain-containing protein. (510 aa)
	F6PKV2_CIOIN	UBIQUITIN_CONJUGAT_2 domain-containing protein. (144 aa)
	LOC100184538	Uncharacterized protein. (623 aa)
	F6QE47_CIOIN	Uncharacterized protein. (433 aa)
	LOC100176733	Cnd3 domain-containing protein. (957 aa)
	F7A5V7_CIOIN	WD_REPEATS_REGION domain-containing protein. (501 aa)
	F7BHD6_CIOIN	FHA domain-containing protein. (474 aa)
	F7AZ70_CIOIN	Bin3-type SAM domain-containing protein. (159 aa)
	LOC100186863	PDZ domain-containing protein GIPC1. (316 aa)
	F6VA91_CIOIN	Uncharacterized protein. (126 aa)
	F6Y4E4_CIOIN	Uncharacterized protein. (163 aa)
	F6TER2_CIOIN	Protein kinase domain-containing protein. (206 aa)
	F7ATN8_CIOIN	RanBD1 domain-containing protein. (211 aa)
	F6PZ91_CIOIN	Uncharacterized protein. (532 aa)
	LOC100179846	Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (344 aa)
	F6VU73_CIOIN	SET domain-containing protein. (453 aa)
	F6SFW9_CIOIN	Fork-head domain-containing protein. (470 aa)
	F6RIW3_CIOIN	Uncharacterized protein. (453 aa)
	F6UNB7_CIOIN	ANAPC5 domain-containing protein. (294 aa)
	F6XM19_CIOIN	Uncharacterized protein. (446 aa)
	F6XLX0_CIOIN	Uncharacterized protein. (936 aa)
	LOC100186373	G1/S-specific cyclin-D2-like; Belongs to the cyclin family. (299 aa)
	F6PNC3_CIOIN	Uncharacterized protein. (1086 aa)
	LOC100183603	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (81 aa)
	H2XJH4_CIOIN	Cyclin N-terminal domain-containing protein. (246 aa)
	H2XJH5_CIOIN	ANK_REP_REGION domain-containing protein. (95 aa)
	H2XJL8_CIOIN	Uncharacterized protein. (292 aa)
	H2XJN2_CIOIN	RECA_2 domain-containing protein. (255 aa)
	H2XJT4_CIOIN	PHD-type domain-containing protein. (508 aa)
	H2XK78_CIOIN	Uncharacterized protein. (147 aa)
	H2XNP0_CIOIN	Uncharacterized protein. (243 aa)
	LOC100182613	Uncharacterized protein. (507 aa)
	H2XRK6_CIOIN	HORMA domain-containing protein. (87 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PKV2_CIOIN	F6QSH0_CIOIN	ENSCINP00000018235	ENSCINP00000013216	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.536
F6PKV2_CIOIN	F6SSU2_CIOIN	ENSCINP00000018235	ENSCINP00000016408	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TPR_REGION domain-containing protein.	0.975
F6PKV2_CIOIN	F6TAK8_CIOIN	ENSCINP00000018235	ENSCINP00000010349	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.630
F6PKV2_CIOIN	F6UNB7_CIOIN	ENSCINP00000018235	ENSCINP00000025938	UBIQUITIN_CONJUGAT_2 domain-containing protein.	ANAPC5 domain-containing protein.	0.948
F6PKV2_CIOIN	F6XLX0_CIOIN	ENSCINP00000018235	ENSCINP00000026188	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.549
F6PKV2_CIOIN	F6XWY9_CIOIN	ENSCINP00000018235	ENSCINP00000015343	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TPR_REGION domain-containing protein.	0.962
F6PKV2_CIOIN	F6ZM08_CIOIN	ENSCINP00000018235	ENSCINP00000008136	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.462
F6PKV2_CIOIN	H2XRK6_CIOIN	ENSCINP00000018235	ENSCINP00000032290	UBIQUITIN_CONJUGAT_2 domain-containing protein.	HORMA domain-containing protein.	0.837
F6PKV2_CIOIN	LOC100176733	ENSCINP00000018235	ENSCINP00000018699	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Cnd3 domain-containing protein.	0.637
F6PKV2_CIOIN	LOC100179846	ENSCINP00000018235	ENSCINP00000024125	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Lymphokine-activated killer T-cell-originated protein kinase isoform X1.	0.889
F6PKV2_CIOIN	LOC100180482	ENSCINP00000018235	ENSCINP00000000293	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Structural maintenance of chromosomes protein.	0.469
F6PKV2_CIOIN	LOC100182084	ENSCINP00000018235	ENSCINP00000003393	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.794
F6PKV2_CIOIN	LOC100182501	ENSCINP00000018235	ENSCINP00000014260	UBIQUITIN_CONJUGAT_2 domain-containing protein.	TPR_REGION domain-containing protein.	0.951
F6PKV2_CIOIN	LOC100183603	ENSCINP00000018235	ENSCINP00000029191	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.552
F6PKV2_CIOIN	LOC100184078	ENSCINP00000018235	ENSCINP00000033367	UBIQUITIN_CONJUGAT_2 domain-containing protein.	CDT1 domain-containing protein.	0.635
F6PKV2_CIOIN	LOC100185658	ENSCINP00000018235	ENSCINP00000036233	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Kinetochore protein NDC80 homolog.	0.817
F6PKV2_CIOIN	LOC100187303	ENSCINP00000018235	ENSCINP00000007280	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.625
F6PL57_CIOIN	LOC100181789	ENSCINP00000006244	ENSCINP00000016652	Uncharacterized protein.	AAA_23 domain-containing protein.	0.471
F6PNC3_CIOIN	F7ATN8_CIOIN	ENSCINP00000028708	ENSCINP00000023601	Uncharacterized protein.	RanBD1 domain-containing protein.	0.523
F6PNC3_CIOIN	LOC100176070	ENSCINP00000028708	ENSCINP00000011710	Uncharacterized protein.	Mitotic spindle assembly checkpoint protein MAD1.	0.509