(93 nodes) Positive regulation of protein kinase activity network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F7B587_CIOIN	Uncharacterized protein. (108 aa)
	Q1RLF0_CIOIN	Zinc finger protein (TRAF/RING)-2. (468 aa)
	LOC100181085	Monocyte to macrophage differentiation factor. (314 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	Dkc1	Uncharacterized protein. (189 aa)
	F6U1X7_CIOIN	Uncharacterized protein. (132 aa)
	LOC100176033	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (263 aa)
	LOC100184540	Death domain-associated protein 6-like isoform X1. (234 aa)
	LOC100183552	ANK_REP_REGION domain-containing protein. (230 aa)
	F6RS66_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (462 aa)
	F6RJA6_CIOIN	Uncharacterized protein. (322 aa)
	F6RI21_CIOIN	Uncharacterized protein. (355 aa)
	LOC100181289	Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	Cifrz	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (866 aa)
	LOC100183152	Uncharacterized protein. (298 aa)
	LOC100180112	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1106 aa)
	F6VN25_CIOIN	Uncharacterized protein. (889 aa)
	F6SAD5_CIOIN	Uncharacterized protein; Belongs to the cyclin family. (514 aa)
	F6WVT9_CIOIN	Protein kinase domain-containing protein. (505 aa)
	F6WEC9_CIOIN	Uncharacterized protein. (1002 aa)
	F6YCG7_CIOIN	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1086 aa)
	LOC100177452	Uncharacterized protein. (603 aa)
	LOC100176030	WD_REPEATS_REGION domain-containing protein. (1206 aa)
	F7BAT7_CIOIN	Prohibitin. (271 aa)
	LOC100183420	Uncharacterized protein. (224 aa)
	LOC100182084	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (461 aa)
	F6T7F9_CIOIN	Uncharacterized protein. (480 aa)
	LOC100175666	MOB kinase activator 3A. (220 aa)
	F6WSD2_CIOIN	BSD domain-containing protein. (400 aa)
	Axin	Uncharacterized protein. (643 aa)
	mapkk3/6	Protein kinase domain-containing protein. (348 aa)
	F6WZS2_CIOIN	Protein kinase domain-containing protein. (1124 aa)
	Mapkk7	Protein kinase domain-containing protein. (478 aa)
	LOC100176205	Programmed cell death protein 10. (217 aa)
	LOC100185957	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1. (624 aa)
	LOC100184903	Tumor protein D52 isoform X4. (180 aa)
	H2Y2K8_CIOIN	Uncharacterized protein. (169 aa)
	H2Y296_CIOIN	Uncharacterized protein. (234 aa)
	H2Y255_CIOIN	CTCK domain-containing protein. (191 aa)
	LOC100183714	G-protein coupled receptor family C group 5 member B-like. (383 aa)
	H2Y0V6_CIOIN	Uncharacterized protein. (204 aa)
	H2Y0N7_CIOIN	Pkinase_Tyr domain-containing protein. (196 aa)
	H2Y0K6_CIOIN	Uncharacterized protein. (3252 aa)
	H2Y0C2_CIOIN	Uncharacterized protein. (138 aa)
	LOC101242758	Protein JTB. (137 aa)
	H2XZ51_CIOIN	Uncharacterized protein. (176 aa)
	H2XYN3_CIOIN	DAGKa domain-containing protein. (184 aa)
	H2XYC1_CIOIN	Fibrinogen C-terminal domain-containing protein. (320 aa)
	H2XXZ3_CIOIN	Uncharacterized protein. (870 aa)
	H2XXJ7_CIOIN	Uncharacterized protein. (347 aa)
	H2XT32_CIOIN	Uncharacterized protein. (127 aa)
	H2XRP4_CIOIN	Uncharacterized protein. (126 aa)
	H2XRB3_CIOIN	Uncharacterized protein. (548 aa)
	H2XPA3_CIOIN	Ras-GEF domain-containing protein. (451 aa)
	H2XN97_CIOIN	Uncharacterized protein. (200 aa)
	Q1RPY5_CIOIN	Zinc finger protein. (579 aa)
	H2XL40_CIOIN	Protein kinase domain-containing protein. (1072 aa)
	H2XJL8_CIOIN	Uncharacterized protein. (292 aa)
	H2XJH4_CIOIN	Cyclin N-terminal domain-containing protein. (246 aa)
	H2XJG5_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. (458 aa)
	LOC100183603	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (81 aa)
	F6VHE0_CIOIN	Uncharacterized protein. (753 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	LOC100179989	PPM-type phosphatase domain-containing protein. (490 aa)
	LOC100186373	G1/S-specific cyclin-D2-like; Belongs to the cyclin family. (299 aa)
	nox4	FAD-binding FR-type domain-containing protein. (811 aa)
	F6UYY4_CIOIN	INCENP_ARK-bind domain-containing protein. (142 aa)
	F6TE72_CIOIN	Protein kinase domain-containing protein. (172 aa)
	Nab1/2	Uncharacterized protein. (397 aa)
	F6V3E7_CIOIN	Protein kinase domain-containing protein. (332 aa)
	F6XCT9_CIOIN	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (256 aa)
	F7ATM0_CIOIN	Uncharacterized protein. (240 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	F6W912_CIOIN	Protein kinase domain-containing protein. (285 aa)
	LOC100178496	CDK2-associated and cullin domain-containing protein 1; Belongs to the cullin family. (294 aa)
	F6X4F9_CIOIN	Uncharacterized protein. (262 aa)
	F6QZH0_CIOIN	Protein kinase domain-containing protein. (459 aa)
	zf(ring)-55	Zinc finger protein. (323 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	LOC100186901	Poly [ADP-ribose] polymerase. (326 aa)
	F6QX80_CIOIN	DAGKc domain-containing protein. (374 aa)
	F6RC10_CIOIN	Uncharacterized protein. (496 aa)
	F7BHD6_CIOIN	FHA domain-containing protein. (474 aa)
	Ephrin-a	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (248 aa)
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	Tgfbr-iib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)
	F6R8W1_CIOIN	G_PROTEIN_RECEP_F1_2 domain-containing protein. (403 aa)
	Egfr1	Receptor protein-tyrosine kinase. (1462 aa)
	F6WNH9_CIOIN	Uncharacterized protein. (219 aa)
	F6WUP4_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	F6ZM08_CIOIN	Uncharacterized protein. (782 aa)
	LOC100177796	Protein kinase domain-containing protein. (308 aa)
	Tak1/mapkkk7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (190 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Axin	Cifrz	ENSCINP00000005332	ENSCINP00000014064	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.508
Axin	F6RS66_CIOIN	ENSCINP00000005332	ENSCINP00000013103	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.593
Cifrz	Axin	ENSCINP00000014064	ENSCINP00000005332	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.508
Cifrz	Mapkk7	ENSCINP00000014064	ENSCINP00000005970	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein kinase domain-containing protein.	0.489
Dkc1	F6RS66_CIOIN	ENSCINP00000009520	ENSCINP00000013103	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.841
Dkc1	F6U1X7_CIOIN	ENSCINP00000009520	ENSCINP00000009527	Uncharacterized protein.	Uncharacterized protein.	0.926
Dkc1	F6W912_CIOIN	ENSCINP00000009520	ENSCINP00000014554	Uncharacterized protein.	Protein kinase domain-containing protein.	0.944
Dkc1	F6WNH9_CIOIN	ENSCINP00000009520	ENSCINP00000006737	Uncharacterized protein.	Uncharacterized protein.	0.489
Egfr1	F6WUP4_CIOIN	ENSCINP00000006067	ENSCINP00000007661	Receptor protein-tyrosine kinase.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.629
Egfr1	LOC100180112	ENSCINP00000006067	ENSCINP00000014240	Receptor protein-tyrosine kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.498
F6QX80_CIOIN	H2XYN3_CIOIN	ENSCINP00000018087	ENSCINP00000034767	DAGKc domain-containing protein.	DAGKa domain-containing protein.	0.949
F6QZH0_CIOIN	LOC100180112	ENSCINP00000016849	ENSCINP00000014240	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.536
F6R8W1_CIOIN	F6YCG7_CIOIN	ENSCINP00000006001	ENSCINP00000000889	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.454
F6RC10_CIOIN	F6XCT9_CIOIN	ENSCINP00000018317	ENSCINP00000023720	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.708
F6RC10_CIOIN	F6ZM08_CIOIN	ENSCINP00000018317	ENSCINP00000008136	Uncharacterized protein.	Uncharacterized protein.	0.423
F6RC10_CIOIN	F7BHD6_CIOIN	ENSCINP00000018317	ENSCINP00000019200	Uncharacterized protein.	FHA domain-containing protein.	0.579
F6RC10_CIOIN	LOC100182084	ENSCINP00000018317	ENSCINP00000003393	Uncharacterized protein.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.435
F6RS66_CIOIN	Axin	ENSCINP00000013103	ENSCINP00000005332	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.593
F6RS66_CIOIN	Dkc1	ENSCINP00000013103	ENSCINP00000009520	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.841
F6RS66_CIOIN	F6SLD6_CIOIN	ENSCINP00000013103	ENSCINP00000027486	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Deacetylase sirtuin-type domain-containing protein.	0.539