(114 nodes) Positive regulation of proteolysis network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100178882	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (167 aa)
	LOC100184285	Programmed cell death protein 5-like. (123 aa)
	LOC100185164	Plasminogen receptor (KT). (152 aa)
	F6U1K7_CIOIN	RBR-type E3 ubiquitin transferase. (510 aa)
	LOC100181983	PRKC apoptosis WT1 regulator protein-like. (304 aa)
	F6UP49_CIOIN	Uncharacterized protein. (1050 aa)
	F6UNP2_CIOIN	WD_REPEATS_REGION domain-containing protein. (464 aa)
	F7B0L4_CIOIN	Uncharacterized protein. (344 aa)
	Sir2-d	Deacetylase sirtuin-type domain-containing protein. (91 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6W768_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (390 aa)
	F6SW20_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (436 aa)
	F6Z3V6_CIOIN	Uncharacterized protein. (1821 aa)
	gsk	Glycogen synthase kinase Alpha/beta. (407 aa)
	F7B314_CIOIN	Uncharacterized protein. (404 aa)
	Axin	Uncharacterized protein. (643 aa)
	F6TN99_CIOIN	Uncharacterized protein. (238 aa)
	F6SDI7_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (435 aa)
	F6SCE7_CIOIN	Uncharacterized protein. (361 aa)
	LOC100186495	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (460 aa)
	F6PHN1_CIOIN	Protein kinase domain-containing protein. (1026 aa)
	LOC100175171	RING finger and CHY zinc finger domain-containing protein 1. (278 aa)
	F6SPV5_CIOIN	RBR-type E3 ubiquitin transferase. (401 aa)
	F6S376_CIOIN	PA28_alpha domain-containing protein. (82 aa)
	F6Z5N9_CIOIN	Rhomboid domain-containing protein. (213 aa)
	F6TBE2_CIOIN	Uncharacterized protein. (444 aa)
	F6XKP0_CIOIN	AAA domain-containing protein; Belongs to the AAA ATPase family. (397 aa)
	F7BHP4_CIOIN	AAA domain-containing protein; Belongs to the AAA ATPase family. (428 aa)
	LOC100182082	AAA domain-containing protein; Belongs to the AAA ATPase family. (463 aa)
	F6XH38_CIOIN	Uncharacterized protein. (637 aa)
	F6WUP4_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	F6XGS0_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	LOC100184190	AAA domain-containing protein; Belongs to the AAA ATPase family. (419 aa)
	F6YHN3_CIOIN	Uncharacterized protein. (728 aa)
	F7B5N7_CIOIN	Protein kinase domain-containing protein. (353 aa)
	F6TSV6_CIOIN	WD_REPEATS_REGION domain-containing protein. (687 aa)
	LOC100176033	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (263 aa)
	myc	Transcription factor protein isoform X1. (681 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	F6Z1D9_CIOIN	PA28_beta domain-containing protein. (255 aa)
	F6U5W6_CIOIN	Uncharacterized protein. (368 aa)
	Ephrin-a	Ephrin RBD domain-containing protein; Belongs to the ephrin family. (248 aa)
	LOC100185096	26S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
	LOC100185957	Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1. (624 aa)
	F6ZHS2_CIOIN	Uncharacterized protein. (484 aa)
	LOC100185251-2	Zinc finger protein. (339 aa)
	F6ZGZ0_CIOIN	Uncharacterized protein. (615 aa)
	F6ZGX7_CIOIN	Uncharacterized protein. (629 aa)
	H2Y3R6_CIOIN	Uncharacterized protein. (156 aa)
	zf(ring)-30	Zinc finger protein. (645 aa)
	F7B1X4_CIOIN	WD_REPEATS_REGION domain-containing protein. (523 aa)
	LOC100183552	ANK_REP_REGION domain-containing protein. (230 aa)
	LOC100181206	TPR_REGION domain-containing protein. (1027 aa)
	F6RJA6_CIOIN	Uncharacterized protein. (322 aa)
	F6RI21_CIOIN	Uncharacterized protein. (355 aa)
	LOC100179215	MYND-type domain-containing protein. (348 aa)
	F6UMP0_CIOIN	RPN13_C domain-containing protein. (379 aa)
	Zf(ubp)-1	Ubiquitin carboxyl-terminal hydrolase. (825 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	F6ULS9_CIOIN	Uncharacterized protein. (608 aa)
	LOC104266675	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (226 aa)
	F6ZJN0_CIOIN	Uncharacterized protein. (203 aa)
	F6WSZ7_CIOIN	Uncharacterized protein. (591 aa)
	F6W673_CIOIN	RBR-type E3 ubiquitin transferase. (502 aa)
	F7AA01_CIOIN	Glucosylceramidase. (561 aa)
	Q1RL49_CIOIN	RBR-type E3 ubiquitin transferase. (455 aa)
	F6T0P8_CIOIN	Uncharacterized protein. (446 aa)
	F6RCH7_CIOIN	Uncharacterized protein. (278 aa)
	LOC100179114	PRELI domain-containing protein 1, mitochondrial-like. (212 aa)
	betaTrCP	Beta-transducin repeat-containing HOMOLOGUE protein. (621 aa)
	F6WXG6_CIOIN	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	LOC100187162	AAA domain-containing protein; Belongs to the AAA ATPase family. (393 aa)
	F6ZTJ9_CIOIN	Uncharacterized protein. (896 aa)
	LOC100182077	TNFAIP3-interacting protein 1 isoform X2. (729 aa)
	F6PIV0_CIOIN	TPR_REGION domain-containing protein. (290 aa)
	F6TJR3_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (242 aa)
	F7AX15_CIOIN	Uncharacterized protein. (632 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	F7AV79_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (228 aa)
	F6PSZ6_CIOIN	Uncharacterized protein. (205 aa)
	F6PSX9_CIOIN	Uncharacterized protein. (240 aa)
	F6V7C2_CIOIN	Protein kinase domain-containing protein. (521 aa)
	F6TTH0_CIOIN	Uncharacterized protein. (426 aa)
	F6ZH48_CIOIN	RING-type domain-containing protein. (285 aa)
	F6YFI1_CIOIN	Uncharacterized protein. (132 aa)
	F6YVN3_CIOIN	Uncharacterized protein. (165 aa)
	F6V0W8_CIOIN	Uncharacterized protein. (235 aa)
	F6ZXH0_CIOIN	Uncharacterized protein. (179 aa)
	ap4	Transcription factor protein isoform X1. (684 aa)
	F6Y9R7_CIOIN	Uncharacterized protein. (556 aa)
	F6UW73_CIOIN	Uncharacterized protein. (301 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	F6X1Y5_CIOIN	Uncharacterized protein. (142 aa)
	LOC100184450	Uncharacterized protein. (240 aa)
	H2XJY8_CIOIN	Glucosylceramidase. (518 aa)
	H2XLM9_CIOIN	PRA1 family protein. (178 aa)
	LOC100179683	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	H2XLX0_CIOIN	WD_REPEATS_REGION domain-containing protein. (328 aa)
	LOC104265547	Uncharacterized protein LOC104265547 isoform X1. (119 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	H2XMX0_CIOIN	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (143 aa)
	H2XR40_CIOIN	RING-type domain-containing protein. (355 aa)
	LOC100177204	Cytosolic carboxypeptidase 6-like isoform X1. (162 aa)
	H2XRM4_CIOIN	Asp_Arg_Hydrox domain-containing protein. (107 aa)
	H2XRS0_CIOIN	TPR_REGION domain-containing protein. (201 aa)
	H2XRY8_CIOIN	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (404 aa)
	LOC100182606	Uncharacterized protein. (568 aa)
	H2XT29_CIOIN	Ncstrn_small domain-containing protein. (568 aa)
	LOC100183633	Death-associated protein 1-like. (103 aa)
	H2XXX0_CIOIN	RBR-type E3 ubiquitin transferase. (216 aa)
	H2Y1D3_CIOIN	Uncharacterized protein. (132 aa)
	H2Y1J2_CIOIN	Uncharacterized protein. (499 aa)
	H2Y1S8_CIOIN	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (162 aa)
	H2Y255_CIOIN	CTCK domain-containing protein. (191 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Axin	F6SDI7_CIOIN	ENSCINP00000005332	ENSCINP00000005898	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.690
Axin	LOC100179683	ENSCINP00000005332	ENSCINP00000030575	Uncharacterized protein.	26S proteasome non-ATPase regulatory subunit 14.	0.401
Axin	betaTrCP	ENSCINP00000005332	ENSCINP00000018885	Uncharacterized protein.	Beta-transducin repeat-containing HOMOLOGUE protein.	0.913
Axin	gsk	ENSCINP00000005332	ENSCINP00000003673	Uncharacterized protein.	Glycogen synthase kinase Alpha/beta.	0.999
Axin	sfrp2	ENSCINP00000005332	ENSCINP00000010646	Uncharacterized protein.	Secreted frizzled-related protein isoform X1.	0.649
F6PIV0_CIOIN	F6YHN3_CIOIN	ENSCINP00000020208	ENSCINP00000008442	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.509
F6PIV0_CIOIN	F7B314_CIOIN	ENSCINP00000020208	ENSCINP00000005320	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.454
F6PIV0_CIOIN	H2XRS0_CIOIN	ENSCINP00000020208	ENSCINP00000032354	TPR_REGION domain-containing protein.	TPR_REGION domain-containing protein.	0.848
F6PSX9_CIOIN	F6WXG6_CIOIN	ENSCINP00000023895	ENSCINP00000019058	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.413
F6PSX9_CIOIN	LOC104266675	ENSCINP00000023895	ENSCINP00000015202	Uncharacterized protein.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.419
F6PSZ6_CIOIN	F6WXG6_CIOIN	ENSCINP00000023893	ENSCINP00000019058	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.413
F6PSZ6_CIOIN	LOC104266675	ENSCINP00000023893	ENSCINP00000015202	Uncharacterized protein.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.419
F6RCH7_CIOIN	F6ZLD5_CIOIN	ENSCINP00000018308	ENSCINP00000022439	Uncharacterized protein.	Protein kinase domain-containing protein.	0.535
F6S376_CIOIN	F6UMP0_CIOIN	ENSCINP00000006551	ENSCINP00000013972	PA28_alpha domain-containing protein.	RPN13_C domain-containing protein.	0.703
F6S376_CIOIN	F6XKP0_CIOIN	ENSCINP00000006551	ENSCINP00000007040	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.667
F6S376_CIOIN	F7BHP4_CIOIN	ENSCINP00000006551	ENSCINP00000007206	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.681
F6S376_CIOIN	LOC100179683	ENSCINP00000006551	ENSCINP00000030575	PA28_alpha domain-containing protein.	26S proteasome non-ATPase regulatory subunit 14.	0.775
F6S376_CIOIN	LOC100182082	ENSCINP00000006551	ENSCINP00000007307	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.638
F6S376_CIOIN	LOC100184190	ENSCINP00000006551	ENSCINP00000008054	PA28_alpha domain-containing protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.632
F6S376_CIOIN	LOC100185096	ENSCINP00000006551	ENSCINP00000011875	PA28_alpha domain-containing protein.	26S proteasome regulatory subunit 7; Belongs to the AAA ATPase family.	0.631