(92 nodes) Embryonic organ development network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Gli	Uncharacterized protein. (1098 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)
	H2Y2A1_CIOIN	Uncharacterized protein. (215 aa)
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	H2Y0K6_CIOIN	Uncharacterized protein. (3252 aa)
	H2XZI8_CIOIN	CRAL-TRIO domain-containing protein. (235 aa)
	H2XZD3_CIOIN	Uncharacterized protein. (221 aa)
	LOC100182939	Homeobox domain-containing protein. (79 aa)
	H2XYC7_CIOIN	Uncharacterized protein. (197 aa)
	hlx	Homeobox domain-containing protein. (554 aa)
	H2XXN7_CIOIN	Uncharacterized protein. (721 aa)
	H2XWC7_CIOIN	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (170 aa)
	LOC100179084	CRAL-TRIO domain-containing protein. (230 aa)
	H2XUQ8_CIOIN	Uncharacterized protein. (225 aa)
	LOC100175445	Uncharacterized protein. (864 aa)
	H2XTC3_CIOIN	Fork-head domain-containing protein. (119 aa)
	H2XSF1_CIOIN	Uncharacterized protein. (125 aa)
	srf	Transcription factor protein. (335 aa)
	H2XRM3_CIOIN	Uncharacterized protein. (212 aa)
	H2XRJ3_CIOIN	Protein kinase domain-containing protein. (195 aa)
	H2XR26_CIOIN	Uncharacterized protein. (102 aa)
	H2XQD2_CIOIN	CRAL-TRIO domain-containing protein. (242 aa)
	H2XPQ9_CIOIN	Uncharacterized protein. (223 aa)
	Foxc	Fork-head domain-containing protein. (510 aa)
	H2XKE2_CIOIN	Uncharacterized protein. (2486 aa)
	H2XJG1_CIOIN	RING-type domain-containing protein. (147 aa)
	LOC100183546	Dynein assembly factor 1, axonemal homolog. (628 aa)
	LOC778836	Homeobox domain-containing protein. (146 aa)
	LOC779004	Transcription factor protein. (553 aa)
	LOC100184081	Uncharacterized protein. (305 aa)
	F6UMH0_CIOIN	WW domain-containing protein. (284 aa)
	F6UMR8_CIOIN	Uncharacterized protein. (477 aa)
	F6U0X3_CIOIN	Uncharacterized protein. (154 aa)
	F6QNW0_CIOIN	Fork-head domain-containing protein. (211 aa)
	F6RDQ7_CIOIN	Uncharacterized protein. (591 aa)
	F6YWM5_CIOIN	BHLH domain-containing protein. (96 aa)
	F7BLV7_CIOIN	Uncharacterized protein. (219 aa)
	F6SFW9_CIOIN	Fork-head domain-containing protein. (470 aa)
	F6TF50_CIOIN	Uncharacterized protein. (1310 aa)
	F6V8F4_CIOIN	Uncharacterized protein. (215 aa)
	F6YJE0_CIOIN	Uncharacterized protein. (772 aa)
	Q4H307_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (249 aa)
	LOC100179157	Coiled-coil domain-containing protein 134. (223 aa)
	F6UXY9_CIOIN	ARID domain-containing protein. (428 aa)
	F6ZDZ6_CIOIN	Uncharacterized protein. (462 aa)
	LOC778828	Uncharacterized protein. (818 aa)
	F6W8G0_CIOIN	WD_REPEATS_REGION domain-containing protein. (504 aa)
	F6WUQ7_CIOIN	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2157 aa)
	F6U8H5_CIOIN	Uncharacterized protein. (1490 aa)
	foxf	Fork-head domain-containing protein. (575 aa)
	F6YM26_CIOIN	Uncharacterized protein. (155 aa)
	pbx	Homeobox domain-containing protein. (446 aa)
	LOC100184699	TBC1 domain family member 23-like. (761 aa)
	tbx2/3	T-box containing transcription factor isoform X2. (803 aa)
	F6TQ49_CIOIN	ANK_REP_REGION domain-containing protein. (147 aa)
	F6X0V6_CIOIN	Uncharacterized protein. (426 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	LOC100176668	Transmembrane emp24 domain-containing protein 2. (203 aa)
	zf(c2h2)-129	Zinc finger protein ZF(C2H2)-129 isoform X1. (687 aa)
	F6Z6K5_CIOIN	Suppressor of fused homolog. (473 aa)
	F7A2I6_CIOIN	Uncharacterized protein. (311 aa)
	LOC100185086	Uncharacterized protein. (126 aa)
	F6UL80_CIOIN	Homeobox domain-containing protein. (287 aa)
	Foxh-a	Fork-head domain-containing protein. (455 aa)
	hox3	Homeoprotein 3 isoform X1. (733 aa)
	F6VEQ7_CIOIN	RFX-type winged-helix domain-containing protein. (624 aa)
	F7A801_CIOIN	Uncharacterized protein. (389 aa)
	F7A8B4_CIOIN	Uncharacterized protein. (495 aa)
	gsc	Transcription factor protein. (257 aa)
	F6VVA7_CIOIN	Homeobox domain-containing protein. (403 aa)
	LOC100184516	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (492 aa)
	kcnq1	Uncharacterized protein; Belongs to the potassium channel family. (520 aa)
	tbx20	Uncharacterized protein. (437 aa)
	F6WLW9_CIOIN	Uncharacterized protein. (1384 aa)
	F7A631_CIOIN	Uncharacterized protein. (221 aa)
	F6TYS5_CIOIN	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (159 aa)
	zf(c2h2)-46	Zinc finger protein (C2H2)-46. (600 aa)
	LOC100176467	Vacuolar protein sorting-associated protein 52 homolog. (694 aa)
	F6UY41_CIOIN	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1100 aa)
	F7AZ43_CIOIN	Uncharacterized protein. (432 aa)
	tbx15/18/22	Uncharacterized protein. (477 aa)
	F6ZYR4_CIOIN	Nipped-B protein. (723 aa)
	Scalloped/tef1	YBD domain-containing protein. (350 aa)
	F6VFN1_CIOIN	TEA domain-containing protein. (85 aa)
	LOC778720	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (510 aa)
	F6ZRY4_CIOIN	NAGLU_C domain-containing protein. (173 aa)
	F7AAA1_CIOIN	Uncharacterized protein. (361 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	F6UPI8_CIOIN	Fork-head domain-containing protein. (596 aa)
	Ci-ZF(ZZ)-7	Zinc finger protein. (619 aa)
	LOC100183377	Vasohibin-1-like isoform X2. (319 aa)
	Tgfbr-iib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ci-ZF(ZZ)-7	H2XJG1_CIOIN	ENSCINP00000001354	ENSCINP00000029793	Zinc finger protein.	RING-type domain-containing protein.	0.895
F6QNW0_CIOIN	LOC779004	ENSCINP00000025574	ENSCINP00000027906	Fork-head domain-containing protein.	Transcription factor protein.	0.506
F6RDQ7_CIOIN	F6YJE0_CIOIN	ENSCINP00000025479	ENSCINP00000022496	Uncharacterized protein.	Uncharacterized protein.	0.799
F6SFW9_CIOIN	LOC779004	ENSCINP00000024412	ENSCINP00000027906	Fork-head domain-containing protein.	Transcription factor protein.	0.409
F6SFW9_CIOIN	srf	ENSCINP00000024412	ENSCINP00000032435	Fork-head domain-containing protein.	Transcription factor protein.	0.669
F6TF50_CIOIN	F6UMH0_CIOIN	ENSCINP00000023576	ENSCINP00000025950	Uncharacterized protein.	WW domain-containing protein.	0.734
F6TF50_CIOIN	F6UMR8_CIOIN	ENSCINP00000023576	ENSCINP00000025949	Uncharacterized protein.	Uncharacterized protein.	0.734
F6TF50_CIOIN	F6X0V6_CIOIN	ENSCINP00000023576	ENSCINP00000017470	Uncharacterized protein.	Uncharacterized protein.	0.455
F6TF50_CIOIN	F6YJE0_CIOIN	ENSCINP00000023576	ENSCINP00000022496	Uncharacterized protein.	Uncharacterized protein.	0.509
F6TF50_CIOIN	H2Y0R6_CIOIN	ENSCINP00000023576	ENSCINP00000035500	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.563
F6TF50_CIOIN	H2Y2G5_CIOIN	ENSCINP00000023576	ENSCINP00000036100	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.563
F6TF50_CIOIN	LOC100184081	ENSCINP00000023576	ENSCINP00000027834	Uncharacterized protein.	Uncharacterized protein.	0.405
F6TF50_CIOIN	LOC779004	ENSCINP00000023576	ENSCINP00000027906	Uncharacterized protein.	Transcription factor protein.	0.471
F6TYS5_CIOIN	F6W8G0_CIOIN	ENSCINP00000010020	ENSCINP00000019657	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	WD_REPEATS_REGION domain-containing protein.	0.989
F6U0X3_CIOIN	F6X0V6_CIOIN	ENSCINP00000025602	ENSCINP00000017470	Uncharacterized protein.	Uncharacterized protein.	0.452
F6U0X3_CIOIN	LOC100184081	ENSCINP00000025602	ENSCINP00000027834	Uncharacterized protein.	Uncharacterized protein.	0.462
F6U8H5_CIOIN	F6WLW9_CIOIN	ENSCINP00000019435	ENSCINP00000010279	Uncharacterized protein.	Uncharacterized protein.	0.998
F6U8H5_CIOIN	F6X0V6_CIOIN	ENSCINP00000019435	ENSCINP00000017470	Uncharacterized protein.	Uncharacterized protein.	0.897
F6U8H5_CIOIN	F7AAA1_CIOIN	ENSCINP00000019435	ENSCINP00000004235	Uncharacterized protein.	Uncharacterized protein.	0.436
F6U8H5_CIOIN	H2Y2A1_CIOIN	ENSCINP00000019435	ENSCINP00000036036	Uncharacterized protein.	Uncharacterized protein.	0.436