(37 nodes) Stem cell differentiation network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6Y6P2_CIOIN	Sema domain-containing protein; Belongs to the semaphorin family. (483 aa)
	LOC100179332	semaphorin-4G-like isoform X3; Belongs to the semaphorin family. (793 aa)
	H2Y1D3_CIOIN	Uncharacterized protein. (132 aa)
	H2XTB6_CIOIN	Uncharacterized protein. (412 aa)
	F6ZX31_CIOIN	Sema domain-containing protein; Belongs to the semaphorin family. (292 aa)
	F6UMH0_CIOIN	WW domain-containing protein. (284 aa)
	F6UMR8_CIOIN	Uncharacterized protein. (477 aa)
	F6QNW0_CIOIN	Fork-head domain-containing protein. (211 aa)
	F7BKY1_CIOIN	Sema domain-containing protein. (229 aa)
	F6VS24_CIOIN	Sema domain-containing protein. (152 aa)
	F6ZHF5_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	F6TTH0_CIOIN	Uncharacterized protein. (426 aa)
	F6ZUG2_CIOIN	Uncharacterized protein. (150 aa)
	F6ZDN3_CIOIN	Sema domain-containing protein. (427 aa)
	F6WNG6_CIOIN	CUB domain-containing protein. (527 aa)
	F6R2H3_CIOIN	Uncharacterized protein. (168 aa)
	tbx2/3	T-box containing transcription factor isoform X2. (803 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	LOC100185622	Programmed cell death protein 6-like. (208 aa)
	LOC100187208	OTU domain-containing protein 5. (592 aa)
	zf(c2h2)-102	ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. (706 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	smad4	Mothers against decapentaplegic homolog. (527 aa)
	gsc	Transcription factor protein. (257 aa)
	soxE	SoxE protein. (808 aa)
	LOC100186374	26S proteasome non-ATPase regulatory subunit 11. (420 aa)
	notrlc	BHLH domain-containing protein. (297 aa)
	LOC100184601	Methyltransferase-like protein 5 isoform X4. (214 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	LOC100184311	Peflin-like. (184 aa)
	LOC100176626	Sorcin-like. (181 aa)
	F6YT91_CIOIN	Uncharacterized protein. (800 aa)
	LOC100186426	Negative elongation factor B. (605 aa)
	srf	Transcription factor protein. (335 aa)
	H2XR16_CIOIN	F-box domain-containing protein. (274 aa)
	Foxc	Fork-head domain-containing protein. (510 aa)
	F6SJR0_CIOIN	Uncharacterized protein. (187 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6UMH0_CIOIN	F6UMR8_CIOIN	ENSCINP00000025950	ENSCINP00000025949	WW domain-containing protein.	Uncharacterized protein.	0.900
F6UMR8_CIOIN	F6UMH0_CIOIN	ENSCINP00000025949	ENSCINP00000025950	Uncharacterized protein.	WW domain-containing protein.	0.900
F6Y6P2_CIOIN	F7BKY1_CIOIN	ENSCINP00000026796	ENSCINP00000024714	Sema domain-containing protein; Belongs to the semaphorin family.	Sema domain-containing protein.	0.423
F6ZHF5_CIOIN	notrlc	ENSCINP00000024208	ENSCINP00000013512	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	BHLH domain-containing protein.	0.452
F6ZHF5_CIOIN	sfrp2	ENSCINP00000024208	ENSCINP00000010646	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Secreted frizzled-related protein isoform X1.	0.963
F7BKY1_CIOIN	F6Y6P2_CIOIN	ENSCINP00000024714	ENSCINP00000026796	Sema domain-containing protein.	Sema domain-containing protein; Belongs to the semaphorin family.	0.423
Foxc	soxE	ENSCINP00000030676	ENSCINP00000001889	Fork-head domain-containing protein.	SoxE protein.	0.509
Tgfbeta2	smad4	ENSCINP00000017469	ENSCINP00000011529	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.550
notrlc	F6ZHF5_CIOIN	ENSCINP00000013512	ENSCINP00000024208	BHLH domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.452
sfrp2	F6ZHF5_CIOIN	ENSCINP00000010646	ENSCINP00000024208	Secreted frizzled-related protein isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.963
smad4	Tgfbeta2	ENSCINP00000011529	ENSCINP00000017469	Mothers against decapentaplegic homolog.	TGF_BETA_2 domain-containing protein.	0.550
soxE	Foxc	ENSCINP00000001889	ENSCINP00000030676	SoxE protein.	Fork-head domain-containing protein.	0.509