(36 nodes) NADP binding network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	LOC100175137	Dihydropteridine reductase isoform X2. (234 aa)
	F6YPB8_CIOIN	Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
	LOC100178943	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (327 aa)
	LOC100179351	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family. (601 aa)
	LOC100175875	Flavin-containing monooxygenase. (423 aa)
	LOC100176643	Uncharacterized protein. (476 aa)
	F7A3K2_CIOIN	6PGD domain-containing protein. (144 aa)
	F6VHJ0_CIOIN	PKS_ER domain-containing protein. (332 aa)
	LOC100175298	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (673 aa)
	F6YLY7_CIOIN	Dimethylaniline monooxygenase [N-oxide-forming]. (493 aa)
	F6SNZ5_CIOIN	Flavin-containing monooxygenase. (313 aa)
	F6SNY7_CIOIN	Flavin-containing monooxygenase. (400 aa)
	F7B7H5_CIOIN	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (521 aa)
	LOC100183540	Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
	LOC100186956	Delta(14)-sterol reductase-like. (598 aa)
	LOC100178763	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
	F6WG12_CIOIN	Uncharacterized protein. (202 aa)
	H2XLB1_CIOIN	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (188 aa)
	LOC100182410	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family. (194 aa)
	H2XQE7_CIOIN	NAD_binding_2 domain-containing protein. (176 aa)
	H2XSI9_CIOIN	Flavin-containing monooxygenase. (217 aa)
	LOC100186457	Glyceraldehyde-3-phosphate dehydrogenase. (334 aa)
	H2Y2K4_CIOIN	3-hydroxy-3-methylglutaryl coenzyme A reductase. (807 aa)
	Q69HP7_CIOIN	D-2-hydroxy-acid dehydrogenase-like. (113 aa)
	H2Y3I7_CIOIN	Uncharacterized protein. (72 aa)
	F7AVB6_CIOIN	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (472 aa)
	F6TIR0_CIOIN	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1024 aa)
	F7AX62_CIOIN	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (482 aa)
	LOC100183039	Nitric oxide synthase; Produces nitric oxide (NO). (1127 aa)
	LOC100182690	Methionine synthase reductase-like. (680 aa)
	LOC100184381	Uncharacterized protein LOC100184381; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	F6Y110_CIOIN	Uncharacterized protein. (269 aa)
	F6T3G6_CIOIN	Uncharacterized protein. (310 aa)
	F6Z1B8_CIOIN	PKS_ER domain-containing protein. (330 aa)
	LOC100180692	Glyoxylate/succinic semialdehyde reductase 1 isoform X2. (473 aa)
	F6WLA0_CIOIN	NAD(P)-bd_dom domain-containing protein. (375 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SNZ5_CIOIN	H2XSI9_CIOIN	ENSCINP00000018800	ENSCINP00000032623	Flavin-containing monooxygenase.	Flavin-containing monooxygenase.	0.946
F6TIR0_CIOIN	LOC100186457	ENSCINP00000007792	ENSCINP00000034531	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.422
F6WLA0_CIOIN	F7AX62_CIOIN	ENSCINP00000010294	ENSCINP00000007539	NAD(P)-bd_dom domain-containing protein.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.528
F7A3K2_CIOIN	F7AVB6_CIOIN	ENSCINP00000015548	ENSCINP00000007825	6PGD domain-containing protein.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.530
F7A3K2_CIOIN	F7AX62_CIOIN	ENSCINP00000015548	ENSCINP00000007539	6PGD domain-containing protein.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.950
F7A3K2_CIOIN	H2XQE7_CIOIN	ENSCINP00000015548	ENSCINP00000031881	6PGD domain-containing protein.	NAD_binding_2 domain-containing protein.	0.951
F7A3K2_CIOIN	LOC100186457	ENSCINP00000015548	ENSCINP00000034531	6PGD domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.596
F7AVB6_CIOIN	F7A3K2_CIOIN	ENSCINP00000007825	ENSCINP00000015548	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	6PGD domain-containing protein.	0.530
F7AVB6_CIOIN	F7AX62_CIOIN	ENSCINP00000007825	ENSCINP00000007539	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	0.692
F7AVB6_CIOIN	F7B7H5_CIOIN	ENSCINP00000007825	ENSCINP00000010672	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.694
F7AVB6_CIOIN	H2XLB1_CIOIN	ENSCINP00000007825	ENSCINP00000030443	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.520
F7AVB6_CIOIN	H2XQE7_CIOIN	ENSCINP00000007825	ENSCINP00000031881	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	NAD_binding_2 domain-containing protein.	0.530
F7AVB6_CIOIN	LOC100178763	ENSCINP00000007825	ENSCINP00000025772	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.494
F7AVB6_CIOIN	LOC100182410	ENSCINP00000007825	ENSCINP00000031349	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Dihydrofolate reductase-like; Belongs to the dihydrofolate reductase family.	0.520
F7AVB6_CIOIN	LOC100184381	ENSCINP00000007825	ENSCINP00000002690	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Uncharacterized protein LOC100184381; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.494
F7AVB6_CIOIN	LOC100186457	ENSCINP00000007825	ENSCINP00000034531	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.681
F7AVB6_CIOIN	Q69HP7_CIOIN	ENSCINP00000007825	ENSCINP00000036343	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	D-2-hydroxy-acid dehydrogenase-like.	0.494
F7AX62_CIOIN	F6WLA0_CIOIN	ENSCINP00000007539	ENSCINP00000010294	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	NAD(P)-bd_dom domain-containing protein.	0.528
F7AX62_CIOIN	F7A3K2_CIOIN	ENSCINP00000007539	ENSCINP00000015548	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	6PGD domain-containing protein.	0.950
F7AX62_CIOIN	F7AVB6_CIOIN	ENSCINP00000007539	ENSCINP00000007825	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.692