(55 nodes) Regulation of epithelial cell proliferation network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	LOC100183377	Vasohibin-1-like isoform X2. (319 aa)
	LOC100176030	WD_REPEATS_REGION domain-containing protein. (1206 aa)
	Ipf1	Homeobox domain-containing protein. (411 aa)
	Zf(c2h2)-69	Uncharacterized protein. (940 aa)
	Sir2-d	Deacetylase sirtuin-type domain-containing protein. (91 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6UJF1_CIOIN	UDENN FLCN/SMCR8-type domain-containing protein. (561 aa)
	LOC778720	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (510 aa)
	Rev-erb	Uncharacterized protein. (597 aa)
	F7APX0_CIOIN	Uncharacterized protein. (1090 aa)
	F6TLB6_CIOIN	Uncharacterized protein. (891 aa)
	LOC100176604	Sulfatase domain-containing protein. (833 aa)
	Xbpa	BZIP domain-containing protein. (309 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	F6YC82_CIOIN	SARAH domain-containing protein. (138 aa)
	F6RS66_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (462 aa)
	ciatpsyna	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (554 aa)
	F6RR11_CIOIN	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (422 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	deaf-1	Deformed epidermal autoregulatory factor 1 homolog isoform X2. (561 aa)
	xbpd	Transcription factor protein isoform X1. (366 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	F6X0V6_CIOIN	Uncharacterized protein. (426 aa)
	Ci-Net	Transcription factor protein. (205 aa)
	LOC100184954	Uncharacterized protein. (760 aa)
	LOC100176974	Uncharacterized protein. (588 aa)
	F6QBE1_CIOIN	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (370 aa)
	Q4H307_CIOIN	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (249 aa)
	F6X972_CIOIN	Uncharacterized protein. (144 aa)
	F6PZ91_CIOIN	Uncharacterized protein. (532 aa)
	F6PSZ6_CIOIN	Uncharacterized protein. (205 aa)
	F6PSX9_CIOIN	Uncharacterized protein. (240 aa)
	F6RLL0_CIOIN	Uncharacterized protein. (322 aa)
	ppar	Nuclear receptor. (644 aa)
	nk4	Transcription factor protein. (623 aa)
	Xbpc	BZIP domain-containing protein. (437 aa)
	F7B221_CIOIN	LIM domain-containing protein. (326 aa)
	F6YVN3_CIOIN	Uncharacterized protein. (165 aa)
	F6XLS2_CIOIN	Uncharacterized protein. (745 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	LOC779004	Transcription factor protein. (553 aa)
	F6W3W9_CIOIN	Uncharacterized protein. (758 aa)
	F6T2G1_CIOIN	Uncharacterized protein. (298 aa)
	H2XJG5_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. (458 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	Bmp2/4	TGFb_propeptide domain-containing protein. (376 aa)
	H2XNY4_CIOIN	EAF domain-containing protein. (241 aa)
	LOC100185578	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1. (297 aa)
	H2XUU5_CIOIN	Uncharacterized protein. (532 aa)
	LOC100183150	WD repeat-containing protein 13-like. (463 aa)
	hlx	Homeobox domain-containing protein. (554 aa)
	H2Y0R6_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (227 aa)
	H2Y2G5_CIOIN	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (160 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmp2/4	Smoothened	ENSCINP00000031019	ENSCINP00000002708	TGFb_propeptide domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.476
Bmp2/4	nk4	ENSCINP00000031019	ENSCINP00000024324	TGFb_propeptide domain-containing protein.	Transcription factor protein.	0.418
F6PZ91_CIOIN	F6X0V6_CIOIN	ENSCINP00000023844	ENSCINP00000017470	Uncharacterized protein.	Uncharacterized protein.	0.452
F6PZ91_CIOIN	LOC100184954	ENSCINP00000023844	ENSCINP00000018073	Uncharacterized protein.	Uncharacterized protein.	0.499
F6RR11_CIOIN	H2Y0R6_CIOIN	ENSCINP00000013130	ENSCINP00000035500	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.680
F6RR11_CIOIN	H2Y2G5_CIOIN	ENSCINP00000013130	ENSCINP00000036100	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.680
F6RR11_CIOIN	ciatpsyna	ENSCINP00000013130	ENSCINP00000013107	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.543
F6RS66_CIOIN	F6SLD6_CIOIN	ENSCINP00000013103	ENSCINP00000027486	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Deacetylase sirtuin-type domain-containing protein.	0.539
F6RS66_CIOIN	LOC100176030	ENSCINP00000013103	ENSCINP00000001261	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.651
F6SLD6_CIOIN	F6RS66_CIOIN	ENSCINP00000027486	ENSCINP00000013103	Deacetylase sirtuin-type domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.539
F6SLD6_CIOIN	Sir2-d	ENSCINP00000027486	ENSCINP00000002463	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.590
F6T2G1_CIOIN	F6TLB6_CIOIN	ENSCINP00000029547	ENSCINP00000007196	Uncharacterized protein.	Uncharacterized protein.	0.950
F6T2G1_CIOIN	F6W3W9_CIOIN	ENSCINP00000029547	ENSCINP00000028344	Uncharacterized protein.	Uncharacterized protein.	0.946
F6TLB6_CIOIN	F6T2G1_CIOIN	ENSCINP00000007196	ENSCINP00000029547	Uncharacterized protein.	Uncharacterized protein.	0.950
F6TLB6_CIOIN	F6W3W9_CIOIN	ENSCINP00000007196	ENSCINP00000028344	Uncharacterized protein.	Uncharacterized protein.	0.949
F6W3W9_CIOIN	F6T2G1_CIOIN	ENSCINP00000028344	ENSCINP00000029547	Uncharacterized protein.	Uncharacterized protein.	0.946
F6W3W9_CIOIN	F6TLB6_CIOIN	ENSCINP00000028344	ENSCINP00000007196	Uncharacterized protein.	Uncharacterized protein.	0.949
F6X0V6_CIOIN	F6PZ91_CIOIN	ENSCINP00000017470	ENSCINP00000023844	Uncharacterized protein.	Uncharacterized protein.	0.452
F6X0V6_CIOIN	LOC100176974	ENSCINP00000017470	ENSCINP00000018086	Uncharacterized protein.	Uncharacterized protein.	0.983
F6X0V6_CIOIN	LOC100184954	ENSCINP00000017470	ENSCINP00000018073	Uncharacterized protein.	Uncharacterized protein.	0.983