(35 nodes) Negative regulation of binding network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6YKG0_CIOIN	MIT domain-containing protein. (236 aa)
	F6SWU7_CIOIN	Uncharacterized protein. (370 aa)
	F6SWL4_CIOIN	Uncharacterized protein. (1355 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F7AMQ2_CIOIN	TPR_REGION domain-containing protein. (186 aa)
	F6X618_CIOIN	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (515 aa)
	F6XTJ3_CIOIN	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (639 aa)
	LOC100180448	Peroxisomal membrane protein PEX14-like isoform X1. (325 aa)
	F7BHN2_CIOIN	Uncharacterized protein. (303 aa)
	F6Y3N8_CIOIN	EF-hand domain-containing protein. (283 aa)
	Hand	BHLH domain-containing protein. (378 aa)
	LOC100187100	Lysine-specific histone demethylase 1A. (705 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	LOC100177439	Serine/threonine/tyrosine-interacting protein-like. (218 aa)
	zf(c2h2)-129	Zinc finger protein ZF(C2H2)-129 isoform X1. (687 aa)
	F6QUI4_CIOIN	Uncharacterized protein. (312 aa)
	stip	Sip1/TFIP11 interacting protein. (832 aa)
	F7AZ70_CIOIN	Bin3-type SAM domain-containing protein. (159 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	LOC100181701	Gem-associated protein 2. (323 aa)
	F6YY15_CIOIN	ERCC4 domain-containing protein. (826 aa)
	F6V4V0_CIOIN	Sortilin. (1459 aa)
	F6YVN3_CIOIN	Uncharacterized protein. (165 aa)
	F7AR88_CIOIN	Uncharacterized protein. (229 aa)
	ap4	Transcription factor protein isoform X1. (684 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	H2XQ41_CIOIN	UDG domain-containing protein. (250 aa)
	H2XR98_CIOIN	Protein kinase domain-containing protein. (365 aa)
	H2XRR8_CIOIN	Uncharacterized protein. (95 aa)
	H2XSG8_CIOIN	Protein kinase domain-containing protein. (305 aa)
	ENSCINP00000032811	annotation not available (79 aa)
	LOC100179235	N_BRCA1_IG domain-containing protein. (241 aa)
	H2XVQ7_CIOIN	WAPL domain-containing protein. (196 aa)
	H2XWK5_CIOIN	Uncharacterized protein. (1089 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SWL4_CIOIN	F6SWU7_CIOIN	ENSCINP00000002657	ENSCINP00000002643	Uncharacterized protein.	Uncharacterized protein.	0.900
F6SWU7_CIOIN	F6SWL4_CIOIN	ENSCINP00000002643	ENSCINP00000002657	Uncharacterized protein.	Uncharacterized protein.	0.900
F6V4V0_CIOIN	F7BHN2_CIOIN	ENSCINP00000024362	ENSCINP00000007208	Sortilin.	Uncharacterized protein.	0.524
F6Y3N8_CIOIN	F7AR88_CIOIN	ENSCINP00000011460	ENSCINP00000025727	EF-hand domain-containing protein.	Uncharacterized protein.	0.945
F6YY15_CIOIN	H2XQ41_CIOIN	ENSCINP00000024251	ENSCINP00000031775	ERCC4 domain-containing protein.	UDG domain-containing protein.	0.482
F7AR88_CIOIN	F6Y3N8_CIOIN	ENSCINP00000025727	ENSCINP00000011460	Uncharacterized protein.	EF-hand domain-containing protein.	0.945
F7BHN2_CIOIN	F6V4V0_CIOIN	ENSCINP00000007208	ENSCINP00000024362	Uncharacterized protein.	Sortilin.	0.524
H2XQ41_CIOIN	F6YY15_CIOIN	ENSCINP00000031775	ENSCINP00000024251	UDG domain-containing protein.	ERCC4 domain-containing protein.	0.482