(16 nodes) NAD+ binding network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100180564	Peroxisomal bifunctional enzyme-like isoform X1. (486 aa)
	LOC100182913	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (731 aa)
	F7BA03_CIOIN	Uncharacterized protein. (322 aa)
	LOC100185251-2	Zinc finger protein. (339 aa)
	LOC100181980	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (725 aa)
	LOC100185848	Deacetylase sirtuin-type domain-containing protein. (357 aa)
	F6YBZ2_CIOIN	Poly [ADP-ribose] polymerase. (381 aa)
	LOC778889	Deacetylase sirtuin-type domain-containing protein. (319 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	Sir2-d	Deacetylase sirtuin-type domain-containing protein. (91 aa)
	F6QM01_CIOIN	Macro domain-containing protein. (247 aa)
	F6R497_CIOIN	Poly [ADP-ribose] polymerase. (353 aa)
	LOC100187496	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like. (309 aa)
	H2XWF2_CIOIN	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (278 aa)
	sir2-a	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (363 aa)
	H2XQR7_CIOIN	NAD(P)-bd_dom domain-containing protein. (408 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SLD6_CIOIN	LOC100185251-2	ENSCINP00000027486	ENSCINP00000012226	Deacetylase sirtuin-type domain-containing protein.	Zinc finger protein.	0.541
F6SLD6_CIOIN	LOC100185848	ENSCINP00000027486	ENSCINP00000023359	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.724
F6SLD6_CIOIN	LOC778889	ENSCINP00000027486	ENSCINP00000027422	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.498
F6SLD6_CIOIN	Sir2-d	ENSCINP00000027486	ENSCINP00000002463	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.590
F6SLD6_CIOIN	sir2-a	ENSCINP00000027486	ENSCINP00000033928	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.605
F7BA03_CIOIN	LOC100180564	ENSCINP00000006899	ENSCINP00000006081	Uncharacterized protein.	Peroxisomal bifunctional enzyme-like isoform X1.	0.535
F7BA03_CIOIN	LOC100181980	ENSCINP00000006899	ENSCINP00000012644	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.471
F7BA03_CIOIN	LOC100182913	ENSCINP00000006899	ENSCINP00000006089	Uncharacterized protein.	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	0.471
H2XWF2_CIOIN	LOC100185251-2	ENSCINP00000033986	ENSCINP00000012226	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Zinc finger protein.	0.642
H2XWF2_CIOIN	LOC100185848	ENSCINP00000033986	ENSCINP00000023359	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.622
H2XWF2_CIOIN	LOC778889	ENSCINP00000033986	ENSCINP00000027422	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.502
H2XWF2_CIOIN	Sir2-d	ENSCINP00000033986	ENSCINP00000002463	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.638
H2XWF2_CIOIN	sir2-a	ENSCINP00000033986	ENSCINP00000033928	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.530
LOC100180564	F7BA03_CIOIN	ENSCINP00000006081	ENSCINP00000006899	Peroxisomal bifunctional enzyme-like isoform X1.	Uncharacterized protein.	0.535
LOC100180564	LOC100181980	ENSCINP00000006081	ENSCINP00000012644	Peroxisomal bifunctional enzyme-like isoform X1.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.924
LOC100180564	LOC100182913	ENSCINP00000006081	ENSCINP00000006089	Peroxisomal bifunctional enzyme-like isoform X1.	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	0.901
LOC100180564	LOC100187496	ENSCINP00000006081	ENSCINP00000007745	Peroxisomal bifunctional enzyme-like isoform X1.	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial-like.	0.954
LOC100181980	F7BA03_CIOIN	ENSCINP00000012644	ENSCINP00000006899	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.471
LOC100181980	LOC100180564	ENSCINP00000012644	ENSCINP00000006081	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Peroxisomal bifunctional enzyme-like isoform X1.	0.924
LOC100181980	LOC100182913	ENSCINP00000012644	ENSCINP00000006089	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Peroxisomal bifunctional enzyme; Belongs to the enoyl-CoA hydratase/isomerase family.	0.925