(47 nodes) Reactive oxygen species metabolic process network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100177202	Uncharacterized protein. (1029 aa)
	H2Y3J4_CIOIN	Flavokinase domain-containing protein. (181 aa)
	H2Y255_CIOIN	CTCK domain-containing protein. (191 aa)
	H2Y0A0_CIOIN	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (156 aa)
	LOC100175802	Peroxiredoxin-like. (235 aa)
	H2XRX8_CIOIN	Uncharacterized protein. (181 aa)
	H2XNI9_CIOIN	Uncharacterized protein. (177 aa)
	LOC100182370	Cytochrome b-245 light chain isoform X1. (175 aa)
	H2XN49_CIOIN	Uncharacterized protein. (140 aa)
	LOC100182592	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like. (202 aa)
	Duox-b	Ferric oxidoreductase domain-containing protein. (85 aa)
	Duox-a	NAD_binding_6 domain-containing protein. (132 aa)
	LOC100185260	Dual oxidase maturation factor 1-like isoform X1. (481 aa)
	F6SUH2_CIOIN	Uncharacterized protein. (230 aa)
	F6TG38_CIOIN	Uncharacterized protein. (582 aa)
	F6TGA3_CIOIN	Uncharacterized protein. (561 aa)
	nox4	FAD-binding FR-type domain-containing protein. (811 aa)
	P47phox	Uncharacterized protein. (461 aa)
	LOC108950015	Mitochondrial inner membrane protease subunit 2-like. (217 aa)
	F6U5Q2_CIOIN	Uncharacterized protein. (203 aa)
	F6U5V0_CIOIN	Uncharacterized protein. (535 aa)
	F6UHP1_CIOIN	Uncharacterized protein. (415 aa)
	P67phox	TPR_REGION domain-containing protein. (515 aa)
	F6ZLD5_CIOIN	Protein kinase domain-containing protein. (164 aa)
	LOC100183052	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (275 aa)
	F6T1X5_CIOIN	Uncharacterized protein. (508 aa)
	F7B882_CIOIN	Uncharacterized protein. (712 aa)
	F6SYX7_CIOIN	Uncharacterized protein. (624 aa)
	F6RI21_CIOIN	Uncharacterized protein. (355 aa)
	F6RJA6_CIOIN	Uncharacterized protein. (322 aa)
	F6QQZ3_CIOIN	Thioredoxin domain-containing protein. (202 aa)
	LOC100185471	Uncharacterized protein; Belongs to the complex I 75 kDa subunit family. (727 aa)
	LOC100181891	Uncharacterized protein. (373 aa)
	F7B7H5_CIOIN	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (521 aa)
	F6S5Z8_CIOIN	Uncharacterized protein. (1133 aa)
	F6TSV2_CIOIN	SEC7 domain-containing protein. (1533 aa)
	LOC100182293	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (217 aa)
	F6YFV6_CIOIN	HMA domain-containing protein. (275 aa)
	Duox-c	Uncharacterized protein. (1552 aa)
	F6U6Y7_CIOIN	Uncharacterized protein. (421 aa)
	F7AD85_CIOIN	Uncharacterized protein. (577 aa)
	per-like	Peroxiredoxin-like. (197 aa)
	LOC445593	Sushi domain-containing protein. (909 aa)
	F7B363_CIOIN	Uncharacterized protein. (1340 aa)
	LOC100180230	Uncharacterized protein. (591 aa)
	LOC100183818	EGF_CA domain-containing protein. (789 aa)
	F6XBM6_CIOIN	Uncharacterized protein. (1509 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Duox-a	Duox-b	ENSCINP00000030367	ENSCINP00000030535	NAD_binding_6 domain-containing protein.	Ferric oxidoreductase domain-containing protein.	0.746
Duox-a	Duox-c	ENSCINP00000030367	ENSCINP00000008209	NAD_binding_6 domain-containing protein.	Uncharacterized protein.	0.544
Duox-a	F6S5Z8_CIOIN	ENSCINP00000030367	ENSCINP00000009017	NAD_binding_6 domain-containing protein.	Uncharacterized protein.	0.939
Duox-a	F6SUH2_CIOIN	ENSCINP00000030367	ENSCINP00000028135	NAD_binding_6 domain-containing protein.	Uncharacterized protein.	0.540
Duox-a	F6XBM6_CIOIN	ENSCINP00000030367	ENSCINP00000001894	NAD_binding_6 domain-containing protein.	Uncharacterized protein.	0.547
Duox-a	F7AD85_CIOIN	ENSCINP00000030367	ENSCINP00000007569	NAD_binding_6 domain-containing protein.	Uncharacterized protein.	0.523
Duox-a	F7B363_CIOIN	ENSCINP00000030367	ENSCINP00000005310	NAD_binding_6 domain-containing protein.	Uncharacterized protein.	0.856
Duox-a	LOC100182370	ENSCINP00000030367	ENSCINP00000031217	NAD_binding_6 domain-containing protein.	Cytochrome b-245 light chain isoform X1.	0.779
Duox-a	LOC100185260	ENSCINP00000030367	ENSCINP00000028174	NAD_binding_6 domain-containing protein.	Dual oxidase maturation factor 1-like isoform X1.	0.533
Duox-a	P67phox	ENSCINP00000030367	ENSCINP00000022493	NAD_binding_6 domain-containing protein.	TPR_REGION domain-containing protein.	0.471
Duox-a	nox4	ENSCINP00000030367	ENSCINP00000026729	NAD_binding_6 domain-containing protein.	FAD-binding FR-type domain-containing protein.	0.636
Duox-b	Duox-a	ENSCINP00000030535	ENSCINP00000030367	Ferric oxidoreductase domain-containing protein.	NAD_binding_6 domain-containing protein.	0.746
Duox-b	Duox-c	ENSCINP00000030535	ENSCINP00000008209	Ferric oxidoreductase domain-containing protein.	Uncharacterized protein.	0.566
Duox-b	F6SUH2_CIOIN	ENSCINP00000030535	ENSCINP00000028135	Ferric oxidoreductase domain-containing protein.	Uncharacterized protein.	0.571
Duox-b	F6XBM6_CIOIN	ENSCINP00000030535	ENSCINP00000001894	Ferric oxidoreductase domain-containing protein.	Uncharacterized protein.	0.771
Duox-b	LOC100182370	ENSCINP00000030535	ENSCINP00000031217	Ferric oxidoreductase domain-containing protein.	Cytochrome b-245 light chain isoform X1.	0.779
Duox-b	LOC100185260	ENSCINP00000030535	ENSCINP00000028174	Ferric oxidoreductase domain-containing protein.	Dual oxidase maturation factor 1-like isoform X1.	0.555
Duox-b	P67phox	ENSCINP00000030535	ENSCINP00000022493	Ferric oxidoreductase domain-containing protein.	TPR_REGION domain-containing protein.	0.471
Duox-b	nox4	ENSCINP00000030535	ENSCINP00000026729	Ferric oxidoreductase domain-containing protein.	FAD-binding FR-type domain-containing protein.	0.636
Duox-c	Duox-a	ENSCINP00000008209	ENSCINP00000030367	Uncharacterized protein.	NAD_binding_6 domain-containing protein.	0.544