(30 nodes) Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6V4V0_CIOIN	Sortilin. (1459 aa)
	F6TS32_CIOIN	c-SKI_SMAD_bind domain-containing protein. (624 aa)
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	LOC100176230	WD_REPEATS_REGION domain-containing protein. (328 aa)
	noggin	Noggin protein precursor. (219 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	LOC100180223	Phenazine biosynthesis-like domain-containing protein 1. (289 aa)
	clip-like	TILa domain-containing protein. (764 aa)
	Dll-a	Homeobox domain-containing protein. (453 aa)
	sfrp2	Secreted frizzled-related protein isoform X1. (293 aa)
	F6T2W0_CIOIN	Uncharacterized protein. (388 aa)
	F6SGS4_CIOIN	Uncharacterized protein. (229 aa)
	F6Q2H6_CIOIN	Uncharacterized protein. (1080 aa)
	F6YAC3_CIOIN	Senescence domain-containing protein. (116 aa)
	F6W446_CIOIN	E3 ubiquitin-protein ligase. (752 aa)
	F6VG31_CIOIN	Uncharacterized protein. (1127 aa)
	F6QUI4_CIOIN	Uncharacterized protein. (312 aa)
	smad6/7	Mothers against decapentaplegic homolog. (361 aa)
	LOC100186609	Uncharacterized protein; Belongs to the heat shock protein 70 family. (671 aa)
	LOC101242470	Uncharacterized protein; Belongs to the heat shock protein 70 family. (659 aa)
	F6RB18_CIOIN	Uncharacterized protein. (838 aa)
	F6ZWC8_CIOIN	Uncharacterized protein. (376 aa)
	F6TYE9_CIOIN	Uncharacterized protein. (102 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	LOC778850	Zinc finger protein. (676 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	H2XTQ4_CIOIN	FCP1 homology domain-containing protein. (119 aa)
	H2XU03_CIOIN	LEM domain-containing protein. (523 aa)
	H2Y052_CIOIN	Uncharacterized protein. (137 aa)
	H2Y0M3_CIOIN	CHRD domain-containing protein. (251 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dll-a	F6T2W0_CIOIN	ENSCINP00000009039	ENSCINP00000012407	Homeobox domain-containing protein.	Uncharacterized protein.	0.400
F6SGS4_CIOIN	F6T2W0_CIOIN	ENSCINP00000012417	ENSCINP00000012407	Uncharacterized protein.	Uncharacterized protein.	0.943
F6SGS4_CIOIN	H2Y0M3_CIOIN	ENSCINP00000012417	ENSCINP00000035457	Uncharacterized protein.	CHRD domain-containing protein.	0.595
F6T2W0_CIOIN	Dll-a	ENSCINP00000012407	ENSCINP00000009039	Uncharacterized protein.	Homeobox domain-containing protein.	0.400
F6T2W0_CIOIN	F6SGS4_CIOIN	ENSCINP00000012407	ENSCINP00000012417	Uncharacterized protein.	Uncharacterized protein.	0.943
F6T2W0_CIOIN	H2Y0M3_CIOIN	ENSCINP00000012407	ENSCINP00000035457	Uncharacterized protein.	CHRD domain-containing protein.	0.573
F6T2W0_CIOIN	noggin	ENSCINP00000012407	ENSCINP00000002170	Uncharacterized protein.	Noggin protein precursor.	0.571
F6TS32_CIOIN	F6W446_CIOIN	ENSCINP00000000131	ENSCINP00000016361	c-SKI_SMAD_bind domain-containing protein.	E3 ubiquitin-protein ligase.	0.416
F6TS32_CIOIN	smad6/7	ENSCINP00000000131	ENSCINP00000018319	c-SKI_SMAD_bind domain-containing protein.	Mothers against decapentaplegic homolog.	0.406
F6W446_CIOIN	F6TS32_CIOIN	ENSCINP00000016361	ENSCINP00000000131	E3 ubiquitin-protein ligase.	c-SKI_SMAD_bind domain-containing protein.	0.416
F6W446_CIOIN	smad6/7	ENSCINP00000016361	ENSCINP00000018319	E3 ubiquitin-protein ligase.	Mothers against decapentaplegic homolog.	0.996
H2Y0M3_CIOIN	F6SGS4_CIOIN	ENSCINP00000035457	ENSCINP00000012417	CHRD domain-containing protein.	Uncharacterized protein.	0.595
H2Y0M3_CIOIN	F6T2W0_CIOIN	ENSCINP00000035457	ENSCINP00000012407	CHRD domain-containing protein.	Uncharacterized protein.	0.573
LOC100176230	LOC100180223	ENSCINP00000000933	ENSCINP00000003373	WD_REPEATS_REGION domain-containing protein.	Phenazine biosynthesis-like domain-containing protein 1.	0.627
LOC100176230	smad6/7	ENSCINP00000000933	ENSCINP00000018319	WD_REPEATS_REGION domain-containing protein.	Mothers against decapentaplegic homolog.	0.650
LOC100180223	LOC100176230	ENSCINP00000003373	ENSCINP00000000933	Phenazine biosynthesis-like domain-containing protein 1.	WD_REPEATS_REGION domain-containing protein.	0.627
LOC100186609	LOC101242470	ENSCINP00000019205	ENSCINP00000019494	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.901
LOC101242470	LOC100186609	ENSCINP00000019494	ENSCINP00000019205	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.901
clip-like	noggin	ENSCINP00000004138	ENSCINP00000002170	TILa domain-containing protein.	Noggin protein precursor.	0.467
noggin	F6T2W0_CIOIN	ENSCINP00000002170	ENSCINP00000012407	Noggin protein precursor.	Uncharacterized protein.	0.571