(127 nodes) Transmembrane transporter complex network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nachr	Uncharacterized protein. (451 aa)
	F6SU74_CIOIN	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (774 aa)
	LOC100176872	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial. (192 aa)
	LOC100184020	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial. (230 aa)
	F6UJB5_CIOIN	MCU domain-containing protein. (322 aa)
	F6VJS2_CIOIN	SH3 domain-containing protein. (461 aa)
	F6U128_CIOIN	Uncharacterized protein. (206 aa)
	F6U137_CIOIN	Uncharacterized protein. (210 aa)
	LOC100186511	Uncharacterized protein. (93 aa)
	F6X5E1_CIOIN	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1645 aa)
	F6VKF0_CIOIN	DAO domain-containing protein. (451 aa)
	F6SYZ4_CIOIN	Cyclic nucleotide-binding domain-containing protein. (435 aa)
	F6ZCY0_CIOIN	DPPIV_N domain-containing protein. (389 aa)
	F6ZD57_CIOIN	Peptidase_S9 domain-containing protein. (363 aa)
	F6TT24_CIOIN	Uncharacterized protein. (184 aa)
	F6ZFR2_CIOIN	Ion_trans domain-containing protein. (217 aa)
	LOC100176555	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like. (113 aa)
	LOC100180061	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like. (113 aa)
	F6VR97_CIOIN	Ion_trans domain-containing protein. (218 aa)
	F6REB5_CIOIN	VWFA domain-containing protein. (1003 aa)
	F6TYK2_CIOIN	L51_S25_CI-B8 domain-containing protein. (49 aa)
	F6U743_CIOIN	ANK_REP_REGION domain-containing protein. (340 aa)
	F6U734_CIOIN	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (710 aa)
	LOC100185261	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8. (192 aa)
	LOC100181003	Coiled-coil domain-containing protein 51-like. (410 aa)
	F6ZIL3_CIOIN	Neur_chan_LBD domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (202 aa)
	F6ST26_CIOIN	Uncharacterized protein. (307 aa)
	LOC100183394	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like. (117 aa)
	F7B2I2_CIOIN	dNK domain-containing protein. (271 aa)
	H2XJT3_CIOIN	Uncharacterized protein. (317 aa)
	H2XK29_CIOIN	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (527 aa)
	LOC100179441	Uncharacterized protein. (61 aa)
	LOC100186976	Voltage-dependent calcium channel subunit alpha-2/delta-1. (1134 aa)
	H2XMA9_CIOIN	Uncharacterized protein; Belongs to the complex I LYR family. (188 aa)
	H2XMR6_CIOIN	Ion_trans domain-containing protein; Belongs to the potassium channel family. (296 aa)
	LOC100180671	Cytochrome b-c1 complex subunit 8-like. (89 aa)
	H2XN49_CIOIN	Uncharacterized protein. (140 aa)
	H2XNE8_CIOIN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (385 aa)
	H2XNI9_CIOIN	Uncharacterized protein. (177 aa)
	H2XRS2_CIOIN	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (657 aa)
	H2XRW4_CIOIN	Uncharacterized protein. (214 aa)
	H2XS61_CIOIN	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (630 aa)
	H2XT96_CIOIN	Neur_chan_memb domain-containing protein. (263 aa)
	H2XTS9_CIOIN	Chloride channel protein. (773 aa)
	H2XTZ3_CIOIN	BTB domain-containing protein. (214 aa)
	H2XU81_CIOIN	Uncharacterized protein. (584 aa)
	H2XVB8_CIOIN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (340 aa)
	LOC100180426	Ion_trans domain-containing protein. (202 aa)
	LOC100187030	Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (104 aa)
	LOC100181042	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (139 aa)
	H2XWR2_CIOIN	Uncharacterized protein. (248 aa)
	H2XX93_CIOIN	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (468 aa)
	H2XX95_CIOIN	Ion_trans domain-containing protein. (192 aa)
	Nachr-4	Uncharacterized protein. (774 aa)
	LOC100176100	Uncharacterized protein. (383 aa)
	H2XYL3_CIOIN	Cytochrome c domain-containing protein. (304 aa)
	LOC100187298	UNC80 domain-containing protein. (2665 aa)
	H2Y004_CIOIN	PBPe domain-containing protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (232 aa)
	H2Y062_CIOIN	Uncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (417 aa)
	H2Y085_CIOIN	Uncharacterized protein. (155 aa)
	H2Y0F0_CIOIN	Ion_trans domain-containing protein. (233 aa)
	H2Y0J5_CIOIN	Ion_trans domain-containing protein; Belongs to the potassium channel family. (512 aa)
	H2Y0K6_CIOIN	Uncharacterized protein. (3252 aa)
	H2Y1Q0_CIOIN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (235 aa)
	H2Y1Y1_CIOIN	Uncharacterized protein. (244 aa)
	H2Y2B7_CIOIN	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (737 aa)
	H2Y2S0_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1873 aa)
	H2Y2W9_CIOIN	Uncharacterized protein. (183 aa)
	NADH2	NADH dehydrogenase subunit 2. (357 aa)
	cytb	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (361 aa)
	NADH1	NADH-ubiquinone oxidoreductase chain 1; Belongs to the complex I subunit 1 family. (302 aa)
	NADH5	NADH dehydrogenase subunit 5. (578 aa)
	F7B065_CIOIN	Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (367 aa)
	F6VDU4_CIOIN	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (616 aa)
	F7ASC5_CIOIN	Uncharacterized protein. (416 aa)
	F6YWA2_CIOIN	Cyclic nucleotide-binding domain-containing protein. (502 aa)
	LOC100183845	Protein tweety homolog; Probable chloride channel. (330 aa)
	F6UUU5_CIOIN	BTB domain-containing protein; Belongs to the potassium channel family. (460 aa)
	LOC100178719	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6. (178 aa)
	LOC100176457	Uncharacterized protein. (246 aa)
	F6YHV1_CIOIN	Cyclic nucleotide-binding domain-containing protein. (200 aa)
	Nachr-3	Neur_chan_memb domain-containing protein. (224 aa)
	F7B6Q8_CIOIN	Uncharacterized protein. (207 aa)
	nachr-5	Nicotinic acetylcholine receptor subunit precursor. (478 aa)
	Nachr-2	Uncharacterized protein. (476 aa)
	F7AQC9_CIOIN	Uncharacterized protein. (174 aa)
	F6SP61_CIOIN	Ion_trans domain-containing protein. (414 aa)
	LOC100183052	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (275 aa)
	F7ADK7_CIOIN	Uncharacterized protein. (254 aa)
	Kcnq4/5	Uncharacterized protein. (702 aa)
	F6TMZ9_CIOIN	Uncharacterized protein; Belongs to the potassium channel family. (439 aa)
	LOC100184418	Uncharacterized protein. (95 aa)
	LOC100177491	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (222 aa)
	ci-glyr	Glycine receptor precursor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (491 aa)
	nachr-4	Acetylcholine receptor subunit beta-like precursor. (499 aa)
	F6WZV6_CIOIN	Cyclic nucleotide-binding domain-containing protein. (499 aa)
	F6TPD4_CIOIN	Uncharacterized protein. (813 aa)
	F6YDA2_CIOIN	Uncharacterized protein. (171 aa)
	F6YMG8_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (561 aa)
	F6YMP1_CIOIN	Ion_trans domain-containing protein. (179 aa)
	LOC100185148	Volume-regulated anion channel subunit LRRC8B. (480 aa)
	LOC100176138	NADH-ubiquinone oxidoreductase 49 kDa subunit-like; Belongs to the complex I 49 kDa subunit family. (471 aa)
	LOC100185471	Uncharacterized protein; Belongs to the complex I 75 kDa subunit family. (727 aa)
	F7AUQ0_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1816 aa)
	F6Z916_CIOIN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (405 aa)
	kcnq1	Uncharacterized protein; Belongs to the potassium channel family. (520 aa)
	F7BFC8_CIOIN	Cyclic nucleotide-binding domain-containing protein. (322 aa)
	F6Z0W4_CIOIN	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (144 aa)
	F6VAX6_CIOIN	Uncharacterized protein. (405 aa)
	F6TAP2_CIOIN	Cyclic nucleotide-binding domain-containing protein. (564 aa)
	F6REB0_CIOIN	BTB domain-containing protein; Belongs to the potassium channel family. (798 aa)
	LOC100179685	Uncharacterized protein. (276 aa)
	LOC100177142	Cation channel sperm-associated protein 2-like. (586 aa)
	F6Y437_CIOIN	Uncharacterized protein. (423 aa)
	F6V6N1_CIOIN	Uncharacterized protein. (807 aa)
	F6YFX5_CIOIN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (482 aa)
	F6YG13_CIOIN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (446 aa)
	F6SKF5_CIOIN	Uncharacterized protein. (1829 aa)
	F6TXN5_CIOIN	Uncharacterized protein. (245 aa)
	F6ZTD1_CIOIN	Uncharacterized protein; Belongs to the potassium channel family. (508 aa)
	nachr-3	Uncharacterized protein. (604 aa)
	F6WZS8_CIOIN	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (320 aa)
	F6YD53_CIOIN	Aldo_ket_red domain-containing protein. (332 aa)
	F7B293_CIOIN	Neur_chan_LBD domain-containing protein. (158 aa)
	nachr-2	Nicotinic acetylcholine receptor subunit precursor. (486 aa)
	F6Q8W5_CIOIN	Ca_chan_IQ domain-containing protein. (1803 aa)
	F6QCF9_CIOIN	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2069 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q8W5_CIOIN	F6REB5_CIOIN	ENSCINP00000004981	ENSCINP00000025169	Ca_chan_IQ domain-containing protein.	VWFA domain-containing protein.	0.890
F6Q8W5_CIOIN	F6SKF5_CIOIN	ENSCINP00000004981	ENSCINP00000008317	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.560
F6Q8W5_CIOIN	F6SP61_CIOIN	ENSCINP00000004981	ENSCINP00000022059	Ca_chan_IQ domain-containing protein.	Ion_trans domain-containing protein.	0.644
F6Q8W5_CIOIN	F6U137_CIOIN	ENSCINP00000004981	ENSCINP00000001651	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.683
F6Q8W5_CIOIN	F6VJS2_CIOIN	ENSCINP00000004981	ENSCINP00000002872	Ca_chan_IQ domain-containing protein.	SH3 domain-containing protein.	0.915
F6Q8W5_CIOIN	F6X5E1_CIOIN	ENSCINP00000004981	ENSCINP00000015622	Ca_chan_IQ domain-containing protein.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.772
F6Q8W5_CIOIN	F7ASC5_CIOIN	ENSCINP00000004981	ENSCINP00000013724	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.645
F6Q8W5_CIOIN	H2XJT3_CIOIN	ENSCINP00000004981	ENSCINP00000029915	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.493
F6Q8W5_CIOIN	H2XWR2_CIOIN	ENSCINP00000004981	ENSCINP00000034096	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.683
F6Q8W5_CIOIN	H2Y085_CIOIN	ENSCINP00000004981	ENSCINP00000035319	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.659
F6Q8W5_CIOIN	H2Y0F0_CIOIN	ENSCINP00000004981	ENSCINP00000035384	Ca_chan_IQ domain-containing protein.	Ion_trans domain-containing protein.	0.651
F6Q8W5_CIOIN	H2Y2W9_CIOIN	ENSCINP00000004981	ENSCINP00000036254	Ca_chan_IQ domain-containing protein.	Uncharacterized protein.	0.651
F6Q8W5_CIOIN	LOC100177142	ENSCINP00000004981	ENSCINP00000009347	Ca_chan_IQ domain-containing protein.	Cation channel sperm-associated protein 2-like.	0.540
F6Q8W5_CIOIN	LOC100186976	ENSCINP00000004981	ENSCINP00000030386	Ca_chan_IQ domain-containing protein.	Voltage-dependent calcium channel subunit alpha-2/delta-1.	0.922
F6Q8W5_CIOIN	LOC100187298	ENSCINP00000004981	ENSCINP00000035111	Ca_chan_IQ domain-containing protein.	UNC80 domain-containing protein.	0.472
F6QCF9_CIOIN	F6REB5_CIOIN	ENSCINP00000004967	ENSCINP00000025169	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	VWFA domain-containing protein.	0.611
F6QCF9_CIOIN	F6SKF5_CIOIN	ENSCINP00000004967	ENSCINP00000008317	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.651
F6QCF9_CIOIN	F6VJS2_CIOIN	ENSCINP00000004967	ENSCINP00000002872	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	SH3 domain-containing protein.	0.670
F6QCF9_CIOIN	F6YMG8_CIOIN	ENSCINP00000004967	ENSCINP00000016580	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.572
F6QCF9_CIOIN	F7AUQ0_CIOIN	ENSCINP00000004967	ENSCINP00000011383	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.566