(106 nodes) Positive regulation of cell motility network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ci-Net	Transcription factor protein. (205 aa)
	snail	Uncharacterized protein. (584 aa)
	F6R265_CIOIN	Epimerase domain-containing protein. (156 aa)
	LOC100186815	Insulin-like growth factor-binding protein 5. (225 aa)
	Fgf8/17/18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (414 aa)
	F6WXG6_CIOIN	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	LOC100186609	Uncharacterized protein; Belongs to the heat shock protein 70 family. (671 aa)
	F7AZD3_CIOIN	Glucose-6-phosphate isomerase; Belongs to the GPI family. (232 aa)
	gla1	Uncharacterized protein LOC780869. (554 aa)
	F6Y9D9_CIOIN	Uncharacterized protein. (768 aa)
	LOC100175467	Cilia- and flagella-associated protein 20 isoform X2. (192 aa)
	LOC101242470	Uncharacterized protein; Belongs to the heat shock protein 70 family. (659 aa)
	F7AD14_CIOIN	Uncharacterized protein. (118 aa)
	F6PIT9_CIOIN	Uncharacterized protein. (210 aa)
	xbpb	Transcription factor protein. (238 aa)
	F6ZDN3_CIOIN	Sema domain-containing protein. (427 aa)
	F6ZUG2_CIOIN	Uncharacterized protein. (150 aa)
	F6TBG7_CIOIN	Uncharacterized protein. (1221 aa)
	F6V921_CIOIN	Uncharacterized protein. (277 aa)
	LOC100176778	Coiled-coil domain-containing protein 25. (207 aa)
	F6PSZ6_CIOIN	Uncharacterized protein. (205 aa)
	F6PSX9_CIOIN	Uncharacterized protein. (240 aa)
	F6TTH0_CIOIN	Uncharacterized protein. (426 aa)
	F6SGC2_CIOIN	Uncharacterized protein. (292 aa)
	Xbpc	BZIP domain-containing protein. (437 aa)
	F6VS24_CIOIN	Sema domain-containing protein. (152 aa)
	F6V3W8_CIOIN	Uncharacterized protein. (264 aa)
	F7BKY1_CIOIN	Sema domain-containing protein. (229 aa)
	F6Q301_CIOIN	Uncharacterized protein. (237 aa)
	F6ZX31_CIOIN	Sema domain-containing protein; Belongs to the semaphorin family. (292 aa)
	F6Y6P2_CIOIN	Sema domain-containing protein; Belongs to the semaphorin family. (483 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	F6ZK41_CIOIN	Kindlin_2_N domain-containing protein. (285 aa)
	LOC100185535	Motile sperm domain-containing protein 2. (246 aa)
	LOC779004	Transcription factor protein. (553 aa)
	F7AK80_CIOIN	Uncharacterized protein. (382 aa)
	F7AIB9_CIOIN	Uncharacterized protein. (271 aa)
	Creb/atf-b	BZIP domain-containing protein. (542 aa)
	LOC100183075	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	H2XM17_CIOIN	FAT domain-containing protein. (187 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	H2XN97_CIOIN	Uncharacterized protein. (200 aa)
	H2XPA3_CIOIN	Ras-GEF domain-containing protein. (451 aa)
	H2XRP4_CIOIN	Uncharacterized protein. (126 aa)
	H2XS74_CIOIN	Uncharacterized protein. (301 aa)
	H2XT32_CIOIN	Uncharacterized protein. (127 aa)
	LOC101243377	Migration and invasion enhancer 1. (76 aa)
	H2XUL2_CIOIN	Uncharacterized protein. (299 aa)
	H2XUW1_CIOIN	CARMIL_C domain-containing protein. (812 aa)
	H2XWT8_CIOIN	Uncharacterized protein. (206 aa)
	H2XWW8_CIOIN	Olfactomedin-like domain-containing protein. (121 aa)
	H2XYX1_CIOIN	Uncharacterized protein. (59 aa)
	H2Y066_CIOIN	Uncharacterized protein. (361 aa)
	H2Y0C2_CIOIN	Uncharacterized protein. (138 aa)
	H2Y0K8_CIOIN	Uncharacterized protein. (467 aa)
	H2Y0V6_CIOIN	Uncharacterized protein. (204 aa)
	LOC100185836	ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (196 aa)
	H2Y1D3_CIOIN	Uncharacterized protein. (132 aa)
	LOC100179332	semaphorin-4G-like isoform X3; Belongs to the semaphorin family. (793 aa)
	H2Y255_CIOIN	CTCK domain-containing protein. (191 aa)
	LOC100185181	Rho family-interacting cell polarization regulator 2-like. (679 aa)
	H2Y2T2_CIOIN	FAT domain-containing protein. (235 aa)
	H2Y3T6_CIOIN	Uncharacterized protein. (196 aa)
	Tgfbr-iib	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (567 aa)
	F6SGI6_CIOIN	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (734 aa)
	F6ZGR3_CIOIN	Uncharacterized protein. (670 aa)
	Tkr	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	wnt5	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	F6RJ65_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (268 aa)
	LOC100181983	PRKC apoptosis WT1 regulator protein-like. (304 aa)
	LOC100176958	Golgi-associated plant pathogenesis-related protein 1 isoform X1; Belongs to the CRISP family. (192 aa)
	F6SBT6_CIOIN	Uncharacterized protein. (66 aa)
	Zf(c2h2)-69	Uncharacterized protein. (940 aa)
	Smoothened	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (441 aa)
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6VK85_CIOIN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (754 aa)
	LOC100178597	Myeloid-associated differentiation marker-like protein 2 isoform X1. (285 aa)
	F6SSQ7_CIOIN	Uncharacterized protein. (660 aa)
	F6Z4V3_CIOIN	Tyrosine-protein kinase. (440 aa)
	F6TBE2_CIOIN	Uncharacterized protein. (444 aa)
	F6WUP4_CIOIN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1014 aa)
	F6S6B2_CIOIN	Phosphoinositide phospholipase C. (1236 aa)
	LOC104266814	ADP-ribosylation factor 6-like; Belongs to the small GTPase superfamily. Arf family. (174 aa)
	F6PMK8_CIOIN	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (710 aa)
	F7B9G3_CIOIN	TGF_BETA_2 domain-containing protein. (387 aa)
	Xbpa	BZIP domain-containing protein. (309 aa)
	F6S5L9_CIOIN	SH3 domain-containing protein. (774 aa)
	LOC100180068	GDP-L-fucose synthase. (317 aa)
	LOC100181537	Junctional adhesion molecule C-like isoform X1. (327 aa)
	F6V299_CIOIN	Protein kinase domain-containing protein. (523 aa)
	F6Q427_CIOIN	Uncharacterized protein. (897 aa)
	LOC100179911	Uncharacterized protein. (1602 aa)
	ciatpsyna	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (554 aa)
	F6RR11_CIOIN	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (422 aa)
	F6RJA6_CIOIN	Uncharacterized protein. (322 aa)
	F6RI21_CIOIN	Uncharacterized protein. (355 aa)
	LOC100176761	WD_REPEATS_REGION domain-containing protein. (383 aa)
	F6UN86_CIOIN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (477 aa)
	LOC100180112	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1106 aa)
	F6UMA7_CIOIN	PID domain-containing protein. (458 aa)
	xbpd	Transcription factor protein isoform X1. (366 aa)
	F6X4F9_CIOIN	Uncharacterized protein. (262 aa)
	F6S4F7_CIOIN	Non-specific serine/threonine protein kinase. (512 aa)
	F7A1R5_CIOIN	Uncharacterized protein. (750 aa)
	Tgfbeta2	TGF_BETA_2 domain-containing protein. (435 aa)
	LOC100177133	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (520 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PIT9_CIOIN	F6TTH0_CIOIN	ENSCINP00000020211	ENSCINP00000024081	Uncharacterized protein.	Uncharacterized protein.	0.451
F6PIT9_CIOIN	F7AIB9_CIOIN	ENSCINP00000020211	ENSCINP00000029357	Uncharacterized protein.	Uncharacterized protein.	0.412
F6PIT9_CIOIN	H2Y1D3_CIOIN	ENSCINP00000020211	ENSCINP00000035717	Uncharacterized protein.	Uncharacterized protein.	0.451
F6PMK8_CIOIN	F6UMA7_CIOIN	ENSCINP00000009846	ENSCINP00000015165	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	PID domain-containing protein.	0.410
F6PMK8_CIOIN	LOC100177697	ENSCINP00000009846	ENSCINP00000002782	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.523
F6PMK8_CIOIN	LOC100178517	ENSCINP00000009846	ENSCINP00000030917	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.523
F6PSX9_CIOIN	F6WXG6_CIOIN	ENSCINP00000023895	ENSCINP00000019058	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.413
F6PSZ6_CIOIN	F6WXG6_CIOIN	ENSCINP00000023893	ENSCINP00000019058	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.413
F6R265_CIOIN	LOC100180068	ENSCINP00000018387	ENSCINP00000011654	Epimerase domain-containing protein.	GDP-L-fucose synthase.	0.901
F6RJ65_CIOIN	F6Z4V3_CIOIN	ENSCINP00000001490	ENSCINP00000006691	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein kinase.	0.729
F6RJ65_CIOIN	H2XM17_CIOIN	ENSCINP00000001490	ENSCINP00000030699	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.928
F6RJ65_CIOIN	H2XWT8_CIOIN	ENSCINP00000001490	ENSCINP00000034122	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.887
F6RJ65_CIOIN	H2Y066_CIOIN	ENSCINP00000001490	ENSCINP00000035300	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.928
F6RJ65_CIOIN	H2Y2T2_CIOIN	ENSCINP00000001490	ENSCINP00000036217	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	FAT domain-containing protein.	0.949
F6RR11_CIOIN	F7AZD3_CIOIN	ENSCINP00000013130	ENSCINP00000019213	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.666
F6RR11_CIOIN	LOC100177133	ENSCINP00000013130	ENSCINP00000017546	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.997
F6RR11_CIOIN	ciatpsyna	ENSCINP00000013130	ENSCINP00000013107	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.543
F6S4F7_CIOIN	F6S6B2_CIOIN	ENSCINP00000016461	ENSCINP00000009002	Non-specific serine/threonine protein kinase.	Phosphoinositide phospholipase C.	0.568
F6S4F7_CIOIN	F6SLD6_CIOIN	ENSCINP00000016461	ENSCINP00000027486	Non-specific serine/threonine protein kinase.	Deacetylase sirtuin-type domain-containing protein.	0.603
F6S4F7_CIOIN	F6VK85_CIOIN	ENSCINP00000016461	ENSCINP00000002868	Non-specific serine/threonine protein kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.587