(36 nodes) Positive regulation of apoptotic signaling pathway network (Ciona intestinalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100177697	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (236 aa)
	F6W768_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (390 aa)
	F6SW20_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (436 aa)
	F6UJQ6_CIOIN	Uncharacterized protein. (345 aa)
	F6UJF1_CIOIN	UDENN FLCN/SMCR8-type domain-containing protein. (561 aa)
	F7A3E4_CIOIN	Zinc finger protein isoform X1. (694 aa)
	p53/p73-a	Transcription factor protein. (489 aa)
	P53/p73-b	Uncharacterized protein. (419 aa)
	atf3	Transcription factor protein isoform X1. (273 aa)
	F6PHM0_CIOIN	Uncharacterized protein. (498 aa)
	F6TLB6_CIOIN	Uncharacterized protein. (891 aa)
	F6XGS0_CIOIN	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	F6PMK8_CIOIN	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (710 aa)
	LOC100176033	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (263 aa)
	LOC100181381	UBX domain-containing protein. (367 aa)
	LOC104266675	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (226 aa)
	F6T957_CIOIN	Uncharacterized protein. (589 aa)
	F6ZJN0_CIOIN	Uncharacterized protein. (203 aa)
	F6Z8I7_CIOIN	Uncharacterized protein. (428 aa)
	LOC100184121	Eukaryotic translation elongation factor 1 epsilon-1-like. (144 aa)
	F6WXG6_CIOIN	Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
	F6XHT6_CIOIN	UvrD-like helicase C-terminal domain-containing protein. (212 aa)
	F7AWL5_CIOIN	F-box domain-containing protein. (431 aa)
	LOC100184050	Serine/threonine/tyrosine-interacting-like protein 1. (296 aa)
	F6YVN3_CIOIN	Uncharacterized protein. (165 aa)
	F6SYE0_CIOIN	Protein kinase domain-containing protein. (216 aa)
	F6ZBN8_CIOIN	CAP-Gly domain-containing protein. (292 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	F6W3W9_CIOIN	Uncharacterized protein. (758 aa)
	F6T2G1_CIOIN	Uncharacterized protein. (298 aa)
	LOC100177760	FAS-associated factor 1-like. (168 aa)
	LOC100178517	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (142 aa)
	LOC100181215	Astrocytic phosphoprotein PEA-15-like. (143 aa)
	zf(ring/rbz)-1	Zn-finger (RING/Ran-binding)-1. (508 aa)
	H2XZY8_CIOIN	Uncharacterized protein. (417 aa)
	LOC100184903	Tumor protein D52 isoform X4. (180 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6PHM0_CIOIN	F6SYE0_CIOIN	ENSCINP00000006295	ENSCINP00000026311	Uncharacterized protein.	Protein kinase domain-containing protein.	0.767
F6PHM0_CIOIN	zf(ring/rbz)-1	ENSCINP00000006295	ENSCINP00000033831	Uncharacterized protein.	Zn-finger (RING/Ran-binding)-1.	0.503
F6PMK8_CIOIN	LOC100177697	ENSCINP00000009846	ENSCINP00000002782	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.523
F6PMK8_CIOIN	LOC100178517	ENSCINP00000009846	ENSCINP00000030917	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.523
F6SW20_CIOIN	F6ZJN0_CIOIN	ENSCINP00000002956	ENSCINP00000015599	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.692
F6SYE0_CIOIN	F6PHM0_CIOIN	ENSCINP00000026311	ENSCINP00000006295	Protein kinase domain-containing protein.	Uncharacterized protein.	0.767
F6SYE0_CIOIN	F6ZBN8_CIOIN	ENSCINP00000026311	ENSCINP00000026477	Protein kinase domain-containing protein.	CAP-Gly domain-containing protein.	0.767
F6SYE0_CIOIN	zf(ring/rbz)-1	ENSCINP00000026311	ENSCINP00000033831	Protein kinase domain-containing protein.	Zn-finger (RING/Ran-binding)-1.	0.578
F6T2G1_CIOIN	F6TLB6_CIOIN	ENSCINP00000029547	ENSCINP00000007196	Uncharacterized protein.	Uncharacterized protein.	0.950
F6T2G1_CIOIN	F6W3W9_CIOIN	ENSCINP00000029547	ENSCINP00000028344	Uncharacterized protein.	Uncharacterized protein.	0.946
F6TLB6_CIOIN	F6T2G1_CIOIN	ENSCINP00000007196	ENSCINP00000029547	Uncharacterized protein.	Uncharacterized protein.	0.950
F6TLB6_CIOIN	F6W3W9_CIOIN	ENSCINP00000007196	ENSCINP00000028344	Uncharacterized protein.	Uncharacterized protein.	0.949
F6W3W9_CIOIN	F6T2G1_CIOIN	ENSCINP00000028344	ENSCINP00000029547	Uncharacterized protein.	Uncharacterized protein.	0.946
F6W3W9_CIOIN	F6TLB6_CIOIN	ENSCINP00000028344	ENSCINP00000007196	Uncharacterized protein.	Uncharacterized protein.	0.949
F6W768_CIOIN	F6ZJN0_CIOIN	ENSCINP00000002830	ENSCINP00000015599	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.692
F6WXG6_CIOIN	LOC104266675	ENSCINP00000019058	ENSCINP00000015202	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.944
F6XGS0_CIOIN	F6ZJN0_CIOIN	ENSCINP00000007986	ENSCINP00000015599	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.692
F6XHT6_CIOIN	F7AWL5_CIOIN	ENSCINP00000019609	ENSCINP00000023021	UvrD-like helicase C-terminal domain-containing protein.	F-box domain-containing protein.	0.498
F6ZBN8_CIOIN	F6SYE0_CIOIN	ENSCINP00000026477	ENSCINP00000026311	CAP-Gly domain-containing protein.	Protein kinase domain-containing protein.	0.767
F6ZBN8_CIOIN	zf(ring/rbz)-1	ENSCINP00000026477	ENSCINP00000033831	CAP-Gly domain-containing protein.	Zn-finger (RING/Ran-binding)-1.	0.503