(28 nodes) Cortical cytoskeleton network (Ciona intestinalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	KYNU-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (467 aa)
	H2Y068_CIOIN	Uncharacterized protein. (219 aa)
	H2XZL1_CIOIN	WD_REPEATS_REGION domain-containing protein. (117 aa)
	KYNU-3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (452 aa)
	LOC100186313	Aminotran_5 domain-containing protein. (255 aa)
	LOC100183424	Uncharacterized protein. (2024 aa)
	H2XQ19_CIOIN	Aminotran_5 domain-containing protein. (346 aa)
	H2XPL3_CIOIN	Uncharacterized protein. (434 aa)
	H2XNX1_CIOIN	EF-hand domain-containing protein. (171 aa)
	H2XNV5_CIOIN	Uncharacterized protein. (927 aa)
	F6YS12_CIOIN	ASD2 domain-containing protein. (256 aa)
	LOC100181631	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (412 aa)
	F6Z8U5_CIOIN	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (281 aa)
	F6U959_CIOIN	Uncharacterized protein. (948 aa)
	F6R808_CIOIN	Uncharacterized protein. (267 aa)
	F6R815_CIOIN	LLGL domain-containing protein. (870 aa)
	F6Q5V5_CIOIN	Spectrin beta chain; Belongs to the spectrin family. (2494 aa)
	F6T3V6_CIOIN	SH3 domain-containing protein. (573 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (451 aa)
	F6RGB2_CIOIN	C2 domain-containing protein. (221 aa)
	F7A8L8_CIOIN	Uncharacterized protein. (519 aa)
	F6UT21_CIOIN	WD_REPEATS_REGION domain-containing protein. (260 aa)
	F6VXM0_CIOIN	Uncharacterized protein. (362 aa)
	LOC100184096	Anillin-like isoform X1. (1027 aa)
	LOC100178597	Myeloid-associated differentiation marker-like protein 2 isoform X1. (285 aa)
	LOC100187427	lanC-like protein 3 isoform X2. (369 aa)
	LOC100181052	Uncharacterized protein. (415 aa)
	F6SDZ0_CIOIN	Uncharacterized protein. (787 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6Q5V5_CIOIN	H2Y068_CIOIN	ENSCINP00000018184	ENSCINP00000035302	Spectrin beta chain; Belongs to the spectrin family.	Uncharacterized protein.	0.935
F6Q5V5_CIOIN	LOC100183424	ENSCINP00000018184	ENSCINP00000032319	Spectrin beta chain; Belongs to the spectrin family.	Uncharacterized protein.	0.971
F6RGB2_CIOIN	F6SDZ0_CIOIN	ENSCINP00000009672	ENSCINP00000000757	C2 domain-containing protein.	Uncharacterized protein.	0.626
F6RGB2_CIOIN	F6U959_CIOIN	ENSCINP00000009672	ENSCINP00000021734	C2 domain-containing protein.	Uncharacterized protein.	0.900
F6SDZ0_CIOIN	F6RGB2_CIOIN	ENSCINP00000000757	ENSCINP00000009672	Uncharacterized protein.	C2 domain-containing protein.	0.626
F6SDZ0_CIOIN	F6U959_CIOIN	ENSCINP00000000757	ENSCINP00000021734	Uncharacterized protein.	Uncharacterized protein.	0.746
F6U959_CIOIN	F6RGB2_CIOIN	ENSCINP00000021734	ENSCINP00000009672	Uncharacterized protein.	C2 domain-containing protein.	0.900
F6U959_CIOIN	F6SDZ0_CIOIN	ENSCINP00000021734	ENSCINP00000000757	Uncharacterized protein.	Uncharacterized protein.	0.746
F6VXM0_CIOIN	F6Z8U5_CIOIN	ENSCINP00000008255	ENSCINP00000023135	Uncharacterized protein.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.462
F6VXM0_CIOIN	H2XQ19_CIOIN	ENSCINP00000008255	ENSCINP00000031753	Uncharacterized protein.	Aminotran_5 domain-containing protein.	0.949
F6VXM0_CIOIN	KYNU	ENSCINP00000008255	ENSCINP00000015824	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.949
F6VXM0_CIOIN	KYNU-2	ENSCINP00000008255	ENSCINP00000031473	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.949
F6VXM0_CIOIN	KYNU-3	ENSCINP00000008255	ENSCINP00000034805	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.949
F6VXM0_CIOIN	LOC100181631	ENSCINP00000008255	ENSCINP00000025991	Uncharacterized protein.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.903
F6VXM0_CIOIN	LOC100186313	ENSCINP00000008255	ENSCINP00000034361	Uncharacterized protein.	Aminotran_5 domain-containing protein.	0.949
F6Z8U5_CIOIN	F6VXM0_CIOIN	ENSCINP00000023135	ENSCINP00000008255	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.462
F6Z8U5_CIOIN	H2XQ19_CIOIN	ENSCINP00000023135	ENSCINP00000031753	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Aminotran_5 domain-containing protein.	0.968
F6Z8U5_CIOIN	KYNU	ENSCINP00000023135	ENSCINP00000015824	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.969
F6Z8U5_CIOIN	KYNU-2	ENSCINP00000023135	ENSCINP00000031473	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.969
F6Z8U5_CIOIN	KYNU-3	ENSCINP00000023135	ENSCINP00000034805	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.968