(11 nodes) DHS-like NAD/FAD-binding domain superfamily network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	F6TD07_CIOIN	Uncharacterized protein. (369 aa)
	Sir2-d	Deacetylase sirtuin-type domain-containing protein. (91 aa)
	LOC100185251-2	Zinc finger protein. (339 aa)
	F6RJV3_CIOIN	ETF domain-containing protein. (334 aa)
	LOC100178631	Uncharacterized protein; Belongs to the TPP enzyme family. (589 aa)
	LOC100177202	Uncharacterized protein. (1029 aa)
	LOC100185848	Deacetylase sirtuin-type domain-containing protein. (357 aa)
	LOC778889	Deacetylase sirtuin-type domain-containing protein. (319 aa)
	F6SLD6_CIOIN	Deacetylase sirtuin-type domain-containing protein. (737 aa)
	sir2-a	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (363 aa)
	H2XWF2_CIOIN	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (278 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SLD6_CIOIN	LOC100177202	ENSCINP00000027486	ENSCINP00000016569	Deacetylase sirtuin-type domain-containing protein.	Uncharacterized protein.	0.900
F6SLD6_CIOIN	LOC100185251-2	ENSCINP00000027486	ENSCINP00000012226	Deacetylase sirtuin-type domain-containing protein.	Zinc finger protein.	0.541
F6SLD6_CIOIN	LOC100185848	ENSCINP00000027486	ENSCINP00000023359	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.724
F6SLD6_CIOIN	LOC778889	ENSCINP00000027486	ENSCINP00000027422	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.498
F6SLD6_CIOIN	Sir2-d	ENSCINP00000027486	ENSCINP00000002463	Deacetylase sirtuin-type domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.590
F6SLD6_CIOIN	sir2-a	ENSCINP00000027486	ENSCINP00000033928	Deacetylase sirtuin-type domain-containing protein.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.605
H2XWF2_CIOIN	LOC100177202	ENSCINP00000033986	ENSCINP00000016569	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Uncharacterized protein.	0.900
H2XWF2_CIOIN	LOC100185251-2	ENSCINP00000033986	ENSCINP00000012226	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Zinc finger protein.	0.642
H2XWF2_CIOIN	LOC100185848	ENSCINP00000033986	ENSCINP00000023359	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.622
H2XWF2_CIOIN	LOC778889	ENSCINP00000033986	ENSCINP00000027422	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.502
H2XWF2_CIOIN	Sir2-d	ENSCINP00000033986	ENSCINP00000002463	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	Deacetylase sirtuin-type domain-containing protein.	0.638
H2XWF2_CIOIN	sir2-a	ENSCINP00000033986	ENSCINP00000033928	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.530
LOC100177202	F6SLD6_CIOIN	ENSCINP00000016569	ENSCINP00000027486	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.900
LOC100177202	H2XWF2_CIOIN	ENSCINP00000016569	ENSCINP00000033986	Uncharacterized protein.	NAD-dependent protein deacylase; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.	0.900
LOC100177202	LOC100185251-2	ENSCINP00000016569	ENSCINP00000012226	Uncharacterized protein.	Zinc finger protein.	0.900
LOC100177202	LOC100185848	ENSCINP00000016569	ENSCINP00000023359	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.900
LOC100177202	LOC778889	ENSCINP00000016569	ENSCINP00000027422	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.900
LOC100177202	Sir2-d	ENSCINP00000016569	ENSCINP00000002463	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.900
LOC100177202	sir2-a	ENSCINP00000016569	ENSCINP00000033928	Uncharacterized protein.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.900
LOC100185251-2	F6SLD6_CIOIN	ENSCINP00000012226	ENSCINP00000027486	Zinc finger protein.	Deacetylase sirtuin-type domain-containing protein.	0.541