(11 nodes) Thiamin diphosphate-binding fold network (Ciona intestinalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	F6TKV3_CIOIN	Transket_pyr domain-containing protein. (781 aa)
	F6UHA9_CIOIN	2-oxogl_dehyd_N domain-containing protein. (264 aa)
	F6V7M4_CIOIN	Transket_pyr domain-containing protein. (156 aa)
	LOC100179963	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. (363 aa)
	F7BBJ9_CIOIN	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (357 aa)
	F6SE92_CIOIN	TPP_enzyme_N domain-containing protein. (220 aa)
	LOC100184477	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (385 aa)
	F6W5P0_CIOIN	TPP_enzyme_C domain-containing protein. (175 aa)
	LOC100178631	Uncharacterized protein; Belongs to the TPP enzyme family. (589 aa)
	F7A429_CIOIN	Transket_pyr domain-containing protein. (631 aa)
	LOC100184456	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (440 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6SE92_CIOIN	F6W5P0_CIOIN	ENSCINP00000000744	ENSCINP00000028050	TPP_enzyme_N domain-containing protein.	TPP_enzyme_C domain-containing protein.	0.973
F6SE92_CIOIN	F7A429_CIOIN	ENSCINP00000000744	ENSCINP00000015532	TPP_enzyme_N domain-containing protein.	Transket_pyr domain-containing protein.	0.552
F6SE92_CIOIN	F7BBJ9_CIOIN	ENSCINP00000000744	ENSCINP00000006593	TPP_enzyme_N domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.607
F6SE92_CIOIN	LOC100179963	ENSCINP00000000744	ENSCINP00000008821	TPP_enzyme_N domain-containing protein.	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial.	0.598
F6SE92_CIOIN	LOC100184456	ENSCINP00000000744	ENSCINP00000016480	TPP_enzyme_N domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.692
F6TKV3_CIOIN	F6UHA9_CIOIN	ENSCINP00000019191	ENSCINP00000012074	Transket_pyr domain-containing protein.	2-oxogl_dehyd_N domain-containing protein.	0.701
F6TKV3_CIOIN	F7BBJ9_CIOIN	ENSCINP00000019191	ENSCINP00000006593	Transket_pyr domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.617
F6TKV3_CIOIN	LOC100179963	ENSCINP00000019191	ENSCINP00000008821	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial.	0.617
F6TKV3_CIOIN	LOC100184456	ENSCINP00000019191	ENSCINP00000016480	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.609
F6TKV3_CIOIN	LOC100184477	ENSCINP00000019191	ENSCINP00000012352	Transket_pyr domain-containing protein.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.557
F6UHA9_CIOIN	F6TKV3_CIOIN	ENSCINP00000012074	ENSCINP00000019191	2-oxogl_dehyd_N domain-containing protein.	Transket_pyr domain-containing protein.	0.701
F6UHA9_CIOIN	F6V7M4_CIOIN	ENSCINP00000012074	ENSCINP00000012048	2-oxogl_dehyd_N domain-containing protein.	Transket_pyr domain-containing protein.	0.973
F6UHA9_CIOIN	F7BBJ9_CIOIN	ENSCINP00000012074	ENSCINP00000006593	2-oxogl_dehyd_N domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.876
F6UHA9_CIOIN	LOC100179963	ENSCINP00000012074	ENSCINP00000008821	2-oxogl_dehyd_N domain-containing protein.	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial.	0.832
F6UHA9_CIOIN	LOC100184456	ENSCINP00000012074	ENSCINP00000016480	2-oxogl_dehyd_N domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.828
F6UHA9_CIOIN	LOC100184477	ENSCINP00000012074	ENSCINP00000012352	2-oxogl_dehyd_N domain-containing protein.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.892
F6V7M4_CIOIN	F6UHA9_CIOIN	ENSCINP00000012048	ENSCINP00000012074	Transket_pyr domain-containing protein.	2-oxogl_dehyd_N domain-containing protein.	0.973
F6V7M4_CIOIN	F7BBJ9_CIOIN	ENSCINP00000012048	ENSCINP00000006593	Transket_pyr domain-containing protein.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.784
F6V7M4_CIOIN	LOC100179963	ENSCINP00000012048	ENSCINP00000008821	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial.	0.825
F6V7M4_CIOIN	LOC100184456	ENSCINP00000012048	ENSCINP00000016480	Transket_pyr domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.822