(8 nodes) Ubiquitin-activating enzyme network (Ciona intestinalis)

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Your Input:
	F7A1S8_CIOIN	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...] (410 aa)
	LOC100176463	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1036 aa)
	LOC100183602	E2_bind domain-containing protein. (446 aa)
	H2XM91_CIOIN	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family. (627 aa)
	F6TZ29_CIOIN	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (678 aa)
	F6YGJ1_CIOIN	ThiF domain-containing protein. (401 aa)
	F6Z8N3_CIOIN	ThiF domain-containing protein. (334 aa)
	LOC100185177	NEDD8-activating enzyme E1 regulatory subunit. (530 aa)

Your Current Organism:

Ciona intestinalis

NCBI taxonomy Id: 7719
Other names: Ascidia intestinalis, C. intestinalis, sea vase, vase tunicate, yellow sea squirt

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6TZ29_CIOIN	F6YGJ1_CIOIN	ENSCINP00000010014	ENSCINP00000008729	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	ThiF domain-containing protein.	0.734
F6TZ29_CIOIN	F7A1S8_CIOIN	ENSCINP00000010014	ENSCINP00000017074	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	0.511
F6TZ29_CIOIN	LOC100176463	ENSCINP00000010014	ENSCINP00000016116	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.	0.816
F6TZ29_CIOIN	LOC100183602	ENSCINP00000010014	ENSCINP00000012570	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	E2_bind domain-containing protein.	0.735
F6TZ29_CIOIN	LOC100185177	ENSCINP00000010014	ENSCINP00000017661	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	NEDD8-activating enzyme E1 regulatory subunit.	0.413
F6YGJ1_CIOIN	F6TZ29_CIOIN	ENSCINP00000008729	ENSCINP00000010014	ThiF domain-containing protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	0.734
F6YGJ1_CIOIN	F6Z8N3_CIOIN	ENSCINP00000008729	ENSCINP00000028233	ThiF domain-containing protein.	ThiF domain-containing protein.	0.473
F6YGJ1_CIOIN	LOC100176463	ENSCINP00000008729	ENSCINP00000016116	ThiF domain-containing protein.	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.	0.810
F6YGJ1_CIOIN	LOC100183602	ENSCINP00000008729	ENSCINP00000012570	ThiF domain-containing protein.	E2_bind domain-containing protein.	0.790
F6Z8N3_CIOIN	F6YGJ1_CIOIN	ENSCINP00000028233	ENSCINP00000008729	ThiF domain-containing protein.	ThiF domain-containing protein.	0.473
F6Z8N3_CIOIN	H2XM91_CIOIN	ENSCINP00000028233	ENSCINP00000030774	ThiF domain-containing protein.	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family.	0.999
F6Z8N3_CIOIN	LOC100183602	ENSCINP00000028233	ENSCINP00000012570	ThiF domain-containing protein.	E2_bind domain-containing protein.	0.524
F7A1S8_CIOIN	F6TZ29_CIOIN	ENSCINP00000017074	ENSCINP00000010014	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	0.511
F7A1S8_CIOIN	H2XM91_CIOIN	ENSCINP00000017074	ENSCINP00000030774	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family.	0.404
F7A1S8_CIOIN	LOC100176463	ENSCINP00000017074	ENSCINP00000016116	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.	0.572
F7A1S8_CIOIN	LOC100183602	ENSCINP00000017074	ENSCINP00000012570	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	E2_bind domain-containing protein.	0.572
F7A1S8_CIOIN	LOC100185177	ENSCINP00000017074	ENSCINP00000017661	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	NEDD8-activating enzyme E1 regulatory subunit.	0.476
H2XM91_CIOIN	F6Z8N3_CIOIN	ENSCINP00000030774	ENSCINP00000028233	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family.	ThiF domain-containing protein.	0.999
H2XM91_CIOIN	F7A1S8_CIOIN	ENSCINP00000030774	ENSCINP00000017074	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family.	Adenylyltransferase and sulfurtransferase MOCS3 homolog; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of the sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards U [...]	0.404
H2XM91_CIOIN	LOC100176463	ENSCINP00000030774	ENSCINP00000016116	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family.	UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family.	0.532